Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania

PLoS Pathogens

Volumn 5, Issue 5, 2009, Pages

  Collin, Nicolas ^a   Gomes, Regis ^a   Teixeira, Clarissa ^a   Cheng, Lily ^a   Laughinghouse, Andre ^a   Ward, Jerrold M ^a   Elnaiem, Dia Eldin ^a   Fischer, Laurent ^b   Valenzuela, Jesus G ^a   Kamhawi, Shaden ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G2; INTERLEUKIN 12; SALIVA PROTEIN; CYTOKINE; INSECT PROTEIN; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BUNYAVIRUS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOG; FEMALE; HOMOGENATE; IMMUNE RESPONSE; IMMUNIZATION; LEISHMANIA; LEISHMANIA INFANTUM; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOLECULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTECTION; PROTEIN EXPRESSION; PSYCHODIDAE; SALIVA; SALIVARY GLAND; SOUTH AND CENTRAL AMERICA; VISCERAL LEISHMANIASIS; ANIMAL; ANTIBODY PRODUCTION; DELAYED HYPERSENSITIVITY; DISEASE CARRIER; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INSECT BITE; METABOLISM; PARASITOLOGY; PHYSIOLOGY; SKIN; STATISTICAL ANALYSIS;

CANIS FAMILIARIS; CRICETINAE; LEISHMANIA INFANTUM; LUTZOMYIA LONGIPALPIS; PHLEBOTOMINAE;

ANIMALS; ANTIBODY FORMATION; CYTOKINES; DATA INTERPRETATION, STATISTICAL; DOGS; FEMALE; GENE EXPRESSION; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; INSECT BITES AND STINGS; INSECT PROTEINS; INSECT VECTORS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LYMPHOCYTES; PSYCHODIDAE; RECOMBINANT PROTEINS; SALIVARY PROTEINS AND PEPTIDES; SKIN;

EID: 67249085574     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000441     Document Type: Article

References (26)

1. Desjeux P (2004) Leishmaniasis. Nat Rev Microbiol 2: 692.
2. Alvar J, Yactayo S, Bern C (2006) Leishmaniasis and poverty. Trends Parasitol 22: 552-557. (Pubitemid 44716723)
3. Werneck GL, Costa CH, Walker AM, David JR, Wand M, et al. (2007) Multilevel modelling of the incidence of visceral leishmaniasis in Teresina, Brazil. Epidemiol Infect 135: 195-201. (Pubitemid 46322057)
4. Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, et al. (2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 5: 873-882.
5. Berman J (2006) Visceral leishmaniasis in the New World & Africa. Indian J Med Res 123: 289-294. (Pubitemid 43905570)
6. Dujardin JC, Campino L, Canavate C, Dedet JP, Gradoni L, et al. (2008) Spread of vector-borne diseases and neglect of Leishmaniasis, Europe. Emerg Infect Dis 14: 1013-1018. (Pubitemid 351920428)
7. Joshi A, Narain JP, Prasittisuk C, Bhatia R, Hashim G, et al. (2008) Can visceral leishmaniasis be eliminated from Asia? J Vector Borne Dis 45: 105-111.
8. Baneth G, Koutinas AF, Solano-Gallego L, Bourdeau P, Ferrer L (2008) Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one. Trends Parasitol 24: 324-330.
9. Palatnik-de-Sousa CB (2008) Vaccines for leishmaniasis in the fore coming 25 years. Vaccine 26: 1709-1724.
10. Palatnik-de-Sousa CB, Barbosa Ade F, Oliveira SM, Nico D, Bernardo RR, et al. (2008) FML vaccine against canine visceral leishmaniasis: from second-generation to synthetic vaccine. Expert Rev Vaccines 7: 833-851.
11. Nogueira FS, Moreira MA, Borja-Cabrera GP, Santos FN, Menz I, et al. (2005) Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs. Vaccine 23: 4805-4810. (Pubitemid 41242874)
12. Parra LE, Borja-Cabrera GP, Santos FN, Souza LO, Palatnik-de-Sousa CB, et al. (2007) Safety trial using the Leishmune vaccine against canine visceral leishmaniasis in Brazil. Vaccine 25: 2180-2186. (Pubitemid 46242143)
13. Belkaid Y, Kamhawi S, Modi G, Valenzuela J, Noben-Trauth N, et al. (1998) Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J Exp Med 188: 1941-1953. (Pubitemid 28536781)
14. Kamhawi S, Belkaid Y, Modi G, Rowton E, Sacks D (2000) Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies. Science 290: 1351-1354. (Pubitemid 30848328)
15. Valenzuela JG, Belkaid Y, Garfield MK, Mendez S, Kamhawi S, et al. (2001) Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. J Exp Med 194: 331-342. (Pubitemid 32730807)
16. Gomes R, Teixeira C, Teixeira MJ, Oliveira F, Menezes MJ, et al. (2008) Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proc Natl Acad Sci U S A 105: 7845-7850. (Pubitemid 351872726)
17. Oliveira F, Lawyer PG, Kamhawi S, Valenzuela JG (2008) Immunity to Distinct Sand Fly Salivary Proteins Primes the Anti-Leishmania Immune Response towards Protection or Exacerbation of Disease. PLoS Negl Trop Dis 2: e226. doi:10.1371/journal.pntd.0000226. (Pubitemid 352002920)
18. Valenzuela JG, Garfield M, Rowton ED, Pham VM (2004) Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi. J Exp Biol 207: 3717-3729. (Pubitemid 39484189)
19. Sacks D, Noben-Trauth N (2002) The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2: 845-858. (Pubitemid 37328707)
20. Kimblin N, Peters N, Debrabant A, Secundino N, Egen J, et al. (2008) Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies. Proc Natl Acad Sci U S A 105: 10125-10130.
21. Vinhas V, Andrade BB, Paes F, Bomura A, Clarencio J, et al. (2007) Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis. Eur J Immunol 37: 3111-3121. (Pubitemid 350131290)
22. Gomes RB, Brodskyn C, de Oliveira CI, Costa J, Miranda JC, et al. (2002) Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity. J Infect Dis 186: 1530-1534. (Pubitemid 35286128)
23. Oliveira F, Kamhawi S, Seitz AE, Pham VM, Guigal PM, et al. (2006) From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library. Vaccine 24: 374-390. (Pubitemid 41790441)
24. Paoletti E, Tartaglia J, Taylor J (1994) Safe and effective poxvirus vectors-NYVAC and ALVAC. Dev Biol Stand 82: 65-69.
25. Giunchetti RC, Correa-Oliveira R, Martins-Filho OA, Teixeira-Carvalho A, Roatt BM, et al. (2008) A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs. Vaccine 26: 623-638.
26. Lemesre JL, Holzmuller P, Cavaleyra M, Goncalves RB, Hottin G, et al. (2005) Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine 23: 2825-2840. (Pubitemid 40386484)