The effects of acute alcohol administration on the human brain: Insights from neuroimaging

Neuropharmacology

Volumn 84, Issue , 2014, Pages 101-110

  Bjork, James M ^a   Gilman, Jodi M ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Addiction; Alcohol; fMRI; Neuroimaging; Positron Emission Tomography

Indexed keywords

ALCOHOL; CENTRAL DEPRESSANT AGENT;

ALCOHOL INTOXICATION; ALCOHOLISM; BEHAVIOR; BRAIN FUNCTION; BRAIN REGION; CORPUS STRIATUM; DECISION MAKING; DOPAMINERGIC ACTIVITY; EMOTION; ENERGY TRANSFER; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NEUROIMAGING; NEUROTOXICITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; BRAIN; BRAIN CIRCULATION; CHEMICALLY INDUCED; COGNITIVE DEFECT; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY; SCINTISCANNING;

ALCOHOL-RELATED DISORDERS; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; ETHANOL; HUMANS; NEUROIMAGING;

EID: 84891720153     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.07.039     Document Type: Review

References (121)

1. S. Alfonso-Loeches, and C. Guerri Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain Crit. Rev. Clin. Lab. Sci. 48 2011 19 47
2. O.M. Alhassoon, S.F. Sorg, M.J. Taylor, R.A. Stephan, B.C. Schweinsburg, N.H. Stricker, A. Gongvatana, and I. Grant Callosal white matter microstructural recovery in abstinent alcoholics: a longitudinal diffusion tensor imaging study Alcohol. Clin. Exp. Res. 36 2012 1922 1931
3. B.M. Anderson, M.C. Stevens, S.A. Meda, K. Jordan, V.D. Calhoun, and G.D. Pearlson Functional imaging of cognitive control during acute alcohol intoxication Alcohol. Clin. Exp. Res. 35 2011 156 165
4. M.H. Baslow Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications Amino Acids 39 2010 1139 1145
5. A. Bechara, A.R. Damasio, H. Damasio, and S.W. Anderson Insensitivity to future consequences following damage to human prefrontal cortex Cognition 50 1994 7 15
6. A. Bechara, and M. Van Der Linden Decision-making and impulse control after frontal lobe injuries Curr. Opin. Neurol. 18 2005 734 739
7. C.F. Beckmann, M. DeLuca, J.T. Devlin, and S.M. Smith Investigations into resting-state connectivity using independent component analysis Philos. Trans. R. Soc. Lond. B Biol. Sci. 360 2005 1001 1013
8. K.C. Berridge, and T.E. Robinson Parsing reward Trends Neurosci. 26 2003 507 513
9. W.K. Bickel, M.L. Miller, R. Yi, B.P. Kowal, D.M. Lindquist, and J.A. Pitcock Behavioral and neuroeconomics of drug addiction: competing neural systems and temporal discounting processes Drug Alcohol Depend. 90 Suppl. 1 2007 S85 S91
10. J.M. Bjork, and D.M. Dougherty Differences in alcohol expectancy between aggressive and nonaggressive social drinkers Alcohol. Clin. Exp. Res. 22 1998 1943 1950
11. J.M. Bjork, S.J. Grant, and D.W. Hommer Cross-sectional volumetric analysis of brain atrophy in alcohol dependence: effects of drinking history and comorbid substance use disorder Am. J. Psychiatry 160 2003 2038 2045
12. J.M. Bjork, R. Momenan, A.R. Smith, and D.W. Hommer Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients Drug Alcohol Depend. 95 2008 115 128
13. J.M. Bjork, A.R. Smith, G. Chen, and D.W. Hommer Mesolimbic recruitment by nondrug rewards in detoxified alcoholics: effort anticipation, reward anticipation, and reward delivery Hum. Brain Mapp. 33 2012 2174 2188
14. I. Boileau, J.M. Assaad, R.O. Pihl, C. Benkelfat, M. Leyton, M. Diksic, R.E. Tremblay, and A. Dagher Alcohol promotes dopamine release in the human nucleus accumbens Synapse 49 2003 226 231
15. E.E. Bouchery, H.J. Harwood, J.J. Sacks, C.J. Simon, and R.D. Brewer Economic costs of excessive alcohol consumption in the U.S., 2006 Am. J. Prev. Med. 41 2011 516 524
16. H.C. Breiter, R.L. Gollub, R.M. Weisskoff, D.N. Kennedy, N. Makris, J.D. Berke, J.M. Goodman, H.L. Kantor, D.R. Gastfriend, J.P. Riorden, R.T. Mathew, B.R. Rosen, and S.E. Hyman Acute effects of cocaine on human brain activity and emotion Neuron 19 1997 591 611
17. V.D. Calhoun, D. Altschul, V. McGinty, R. Shih, D. Scott, E. Sears, and G.D. Pearlson Alcohol intoxication effects on visual perception: an fMRI study Hum. Brain Mapp. 21 2004 15 26
18. J. Camchong, A. Stenger, and G. Fein Resting-state synchrony in long-term abstinent alcoholics Alcohol. Clin. Exp. Res. 37 2013 75 85
19. O. Ciccarelli, M. Catani, H. Johansen-Berg, C. Clark, and A. Thompson Diffusion-based tractography in neurological disorders: concepts, applications, and future developments Lancet Neurol. 7 2008 715 727
20. D.M. Cole, S.M. Smith, and C.F. Beckmann Advances and pitfalls in the analysis and interpretation of resting-state FMRI data Front. Syst. Neurosci. 4 2010 8
21. M. Corbetta, and G.L. Shulman Control of goal-directed and stimulus-driven attention in the brain Nat. Rev. Neurosci. 3 2002 201 215
22. F.T. Crews, and C.A. Boettiger Impulsivity, frontal lobes and risk for addiction Pharmacol. Biochem. Behav. 93 2009 237 247
23. F.T. Crews, T. Buckley, P.R. Dodd, G. Ende, N. Foley, C. Harper, J. He, D. Innes, W. Loh el, A. Pfefferbaum, J. Zou, and E.V. Sullivan Alcoholic neurobiology: changes in dependence and recovery Alcohol. Clin. Exp. Res. 29 2005 1504 1513
24. T. Demirakca, G. Ende, N. Kammerer, H. Welzel-Marquez, D. Hermann, A. Heinz, and K. Mann Effects of alcoholism and continued abstinence on brain volumes in both genders Alcohol. Clin. Exp. Res. 35 2011 1678 1685
25. D.M. Dougherty, J.M. Bjork, R.A. Harper, C.W. Mathias, F.G. Moeller, and D.M. Marsh Validation of the immediate and delayed memory tasks in hospitalized adolescents with disruptive behavior disorders Psychol. Rec. 53 2003 509 532
26. D.M. Dougherty, F.G. Moeller, J.L. Steinberg, D.M. Marsh, S.E. Hines, and J.M. Bjork Alcohol increases commission error rates for a continuous performance test Alcohol. Clin. Exp. Res. 23 1999 1342 1351
27. M.J. Eckardt, S.E. File, G.L. Gessa, K.A. Grant, C. Guerri, P.L. Hoffman, H. Kalant, G.F. Koob, T.K. Li, and B. Tabakoff Effects of moderate alcohol consumption on the central nervous system Alcohol. Clin. Exp. Res. 22 1998 998 1040
28. F. Esposito, G. Pignataro, G. Di Renzo, A. Spinali, A. Paccone, G. Tedeschi, and L. Annunziato Alcohol increases spontaneous BOLD signal fluctuations in the visual network Neuroimage 53 2010 534 543
29. F. Fadda, and Z.L. Rossetti Chronic ethanol consumption: from neuroadaptation to neurodegeneration Prog. Neurobiol. 56 1998 385 431
30. G. Fein, V. Di Sclafani, V.A. Cardenas, H. Goldmann, M. Tolou-Shams, and D.J. Meyerhoff Cortical gray matter loss in treatment-naive alcohol dependent individuals Alcohol. Clin. Exp. Res. 26 2002 558 564
31. G. Fein, B. Landman, H. Tran, S. McGillivray, P. Finn, J. Barakos, and K. Moon Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task Neuroimage 32 2006 1465 1471
32. R.S. Feldman, J.S. Meyer, and L.F. Quenzer Principles of Neuropsychopharmacology 1997 Sinauer Associates, Inc. Sunderland, MA
33. M.T. Fillmore, and J. Blackburn Compensating for alcohol-induced impairment: alcohol expectancies and behavioral disinhibition J. Stud. Alcohol 63 2002 237 246
34. M.D. Fox, and M.E. Raichle Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging Nat. Rev. Neurosci. 8 2007 700 711
35. S. Gazdzinski, T.C. Durazzo, C. Studholme, E. Song, P. Banys, and D.J. Meyerhoff Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes Alcohol. Clin. Exp. Res. 29 2005 1484 1495
36. J.M. Gilman, V.A. Ramchandani, T. Crouss, and D.W. Hommer Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns Neuropsychopharmacology 37 2012 467 477
37. J.M. Gilman, A.R. Smith, V.A. Ramchandani, R. Momenan, and D.W. Hommer The effect of intravenous alcohol on the neural correlates of risky decision making in healthy social drinkers Addict. Biol. 17 2012 465 478
38. J.M. Gilman, V.A. Ramchandani, M.B. Davis, J.M. Bjork, and D.W. Hommer Why we like to drink: a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol J. Neurosci. 28 2008 4583 4591
39. A. Giorgio, L. Santelli, V. Tomassini, R. Bosnell, S. Smith, N. De Stefano, and H. Johansen-Berg Age-related changes in grey and white matter structure throughout adulthood Neuroimage 51 2010 943 951
40. R. Gomez, K.L. Behar, J. Watzl, S.A. Weinzimer, B. Gulanski, G. Sanacora, J. Koretski, E. Guidone, L. Jiang, I.L. Petrakis, B. Pittman, J.H. Krystal, and G.F. Mason Intravenous ethanol infusion decreases human cortical gamma-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla Biol. Psychiatry 71 2012 239 246
41. H. Gundersen, R. Gruner, K. Specht, and K. Hugdahl The effects of alcohol intoxication on neuronal activation at different levels of cognitive load Open Neuroimag. J. 2 2008 65 72
42. R.C. Gur, F.M. Gunning-Dixon, B.I. Turetsky, W.B. Bilker, and R.E. Gur Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults Am. J. Geriatr. Psychiatry 10 2002 72 80
43. S.N. Haber, and B. Knutson The reward circuit: linking primate anatomy and human imaging Neuropsychopharmacology 35 2010 4 26
44. T.A. Hare, C.F. Camerer, and A. Rangel Self-control in decision-making involves modulation of the vmPFC valuation system Science 324 2009 646 648
45. D. Hermann, W. Weber-Fahr, A. Sartorius, M. Hoerst, U. Frischknecht, N. Tunc-Skarka, S. Perreau-Lenz, A.C. Hansson, B. Krumm, F. Kiefer, R. Spanagel, K. Mann, G. Ende, and W.H. Sommer Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats Biol. Psychiatry 71 2012 1015 1021
46. P.N. Hoaken, and S.H. Stewart Drugs of abuse and the elicitation of human aggressive behavior Addict. Behav. 28 2003 1533 1554
47. D. Hommer, R. Momenan, E. Kaiser, and R. Rawlings Evidence for a gender-related effect of alcoholism on brain volumes Am. J. Psychiatry 158 2001 198 204
48. D. Hommer, R. Momenan, R. Rawlings, P. Ragan, W. Williams, D. Rio, and M. Eckardt Decreased corpus callosum size among alcoholic women Arch. Neurol. 53 1996 359 363
49. M. Ingvar, P.H. Ghatan, A. Wirsen-Meurling, J. Risberg, G. Von Heijne, S. Stone-Elander, and D.H. Ingvar Alcohol activates the cerebral reward system in man J. Stud. Alcohol 59 1998 258 269
50. T.L. Jernigan, L.M. Zatz, A.J. Ahumada Jr., A. Pfefferbaum, J.R. Tinklenberg, and J.A. Moses Jr. CT measures of cerebrospinal fluid volume in alcoholics and normal volunteers Psychiatry Res. 7 1982 9 17
51. J.W. Kable, and P.W. Glimcher The neural correlates of subjective value during intertemporal choice Nat. Neurosci. 10 2007 1625 1633
52. Y. Kawano Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease Hypertens. Res. 33 2010 181 191
53. N. Khalili-Mahani, R.M. Zoethout, C.F. Beckmann, E. Baerends, M.L. de Kam, R.P. Soeter, A. Dahan, M.A. van Buchem, J.M. van Gerven, and S.A. Rombouts Effects of morphine and alcohol on functional brain connectivity during "resting state": a placebo-controlled crossover study in healthy young men Hum. Brain Mapp. 33 2012 1003 1018
54. M.J. Kim, R.A. Loucks, A.L. Palmer, A.C. Brown, K.M. Solomon, A.N. Marchante, and P.J. Whalen The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety Behav. Brain Res. 223 2011 403 410
55. S.G. Kim, and S. Ogawa Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals J. Cereb. Blood Flow Metab. 32 2012 1188 1206
56. L.M. Kong, W.B. Zheng, G.P. Lian, and H.D. Zhang Acute effects of alcohol on the human brain: diffusion tensor imaging study AJNR Am. J. Neuroradiol 33 2012 928 934
57. G.F. Koob, and M. Le Moal Addiction and the brain antireward system Annu. Rev. Psychol. 59 2008 29 53
58. M. Kubota, S. Nakazaki, S. Hirai, N. Saeki, A. Yamaura, and T. Kusaka Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects J. Neurol. Neurosurg. Psychiatry 71 2001 104 106
59. A.R. Laird, P.M. Fox, S.B. Eickhoff, J.A. Turner, K.L. Ray, D.R. McKay, D.C. Glahn, C.F. Beckmann, S.M. Smith, and P.T. Fox Behavioral interpretations of intrinsic connectivity networks J. Cogn. Neurosci. 23 2011 4022 4037
60. S.D. Lane, D.R. Cherek, C.J. Pietras, and O.V. Tcheremissine Alcohol effects on human risk taking Psychopharmacology (Berl) 172 2004 68 77
61. M.A. Lau, R.O. Pihl, and J.B. Peterson Provocation, acute alcohol intoxication, cognitive performance, and aggression J. Abnorm. Psychol. 104 1995 150 155
62. K.E. Leonard, and H.T. Blane Alcohol expectancies and personality characteristics in young men Addict. Behav. 13 1988 353 357
63. J.M. Levin, M.H. Ross, J.H. Mendelson, M.J. Kaufman, N. Lange, L.C. Maas, N.K. Mello, B.M. Cohen, and P.F. Renshaw Reduction in BOLD fMRI response to primary visual stimulation following alcohol ingestion Psychiatry Res. 82 1998 135 146
64. R.E. Lindman, and A.R. Lang The alcohol-aggression stereotype: a cross-cultural comparison of beliefs Int. J. Addict. 29 1994 1 13
65. R.E. Lindman, B.A. Sjoholm, and A.R. Lang Expectations of alcohol-induced positive affect: a cross-cultural comparison J. Stud. Alcohol 61 2000 681 687
66. T.T. Liu, and G.G. Brown Measurement of cerebral perfusion with arterial spin labeling: part 1. Methods J. Int. Neuropsychol. Soc. 13 2007 517 525
67. N.K. Logothetis The underpinnings of the BOLD functional magnetic resonance imaging signal J. Neurosci. 23 2003 3963 3971
68. M. Luchtmann, K. Jachau, C. Tempelmann, and J. Bernarding Alcohol induced region-dependent alterations of hemodynamic response: implications for the statistical interpretation of pharmacological fMRI studies Exp. Brain Res. 204 2010 1 10
69. D. Martinez, R. Gil, M. Slifstein, D.R. Hwang, Y. Huang, A. Perez, L. Kegeles, P. Talbot, S. Evans, J. Krystal, M. Laruelle, and A. Abi-Dargham Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol. Psychiatry 58 2005 779 786
70. R.J. Mathew, and W.H. Wilson Regional cerebral blood flow changes associated with ethanol intoxication Stroke 17 1986 1156 1159
71. S.A. Meda, V.D. Calhoun, R.S. Astur, B.M. Turner, K. Ruopp, and G.D. Pearlson Alcohol dose effects on brain circuits during simulated driving: an fMRI study Hum. Brain Mapp. 30 2009 1257 1270
72. M. Mennes, C. Kelly, X.N. Zuo, A. Di Martino, B.B. Biswal, F.X. Castellanos, and M.P. Milham Inter-individual differences in resting-state functional connectivity predict task-induced BOLD activity Neuroimage 50 2010 1690 1701
73. C.M. Moore, B.B. Frederick, and P.F. Renshaw Brain biochemistry using magnetic resonance spectroscopy: relevance to psychiatric illness in the elderly J. Geriatr. Psychiatry Neurol. 12 1999 107 117
74. E.J. Neafsey, and M.A. Collins Moderate alcohol consumption and cognitive risk Neuropsychiatr Dis. Treat 7 2011 465 484
75. D.B. Newlin, C.J. Golden, M. Quaife, and B. Graber Effect of alcohol ingestion on regional cerebral blood flow Int. J. Neurosci. 17 1982 145 150
76. J.P. Newman, and J.F. Wallace Diverse pathways to deficient self-regulation: implications for disinhibitory psychopathology in children Clin. Psychol. Rev. 13 1993 699 720
77. M. Oscar-Berman, and K. Marinkovic Alcohol: effects on neurobehavioral functions and the brain Neuropsychol. Rev. 17 2007 239 257
78. C.B. Padula, A.N. Simmons, S.C. Matthews, S.K. Robinson, S.F. Tapert, M.A. Schuckit, and M.P. Paulus Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study Alcohol Alcohol. 46 2011 547 552
79. D. Pardini, H.R. White, and M. Stouthamer-Loeber Early adolescent psychopathology as a predictor of alcohol use disorders by young adulthood Drug Alcohol Depend. 88 Suppl. 1 2007 S38 S49
80. C.A. Paul, R. Au, L. Fredman, J.M. Massaro, S. Seshadri, C. Decarli, and P.A. Wolf Association of alcohol consumption with brain volume in the Framingham study Arch. Neurol. 65 2008 1363 1367
81. M.P. Paulus, S.F. Tapert, C. Pulido, and M.A. Schuckit Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol Alcohol. Clin. Exp. Res. 30 2006 1363 1371
82. M. Pecina, H. Azhar, T.M. Love, T. Lu, B.L. Fredrickson, C.S. Stohler, and J.K. Zubieta Personality trait predictors of placebo analgesia and neurobiological correlates Neuropsychopharmacology 38 2013 639 646
83. A. Pfefferbaum, K.O. Lim, R.B. Zipursky, D.H. Mathalon, M.J. Rosenbloom, B. Lane, C.N. Ha, and E.V. Sullivan Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study Alcohol Clin. Exp. Res. 16 1992 1078 1089
84. A. Pfefferbaum, M. Rosenbloom, K. Crusan, and T.L. Jernigan Brain CT changes in alcoholics: effects of age and alcohol consumption Alcohol. Clin. Exp. Res. 12 1988 81 87
85. A. Pfefferbaum, M. Rosenbloom, A. Deshmukh, and E. Sullivan Sex differences in the effects of alcohol on brain structure Am. J. Psychiatry 158 2001 188 197
86. A. Pfefferbaum, M.J. Rosenbloom, R. Fama, S.A. Sassoon, and E.V. Sullivan Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: selective relations to dissociable functions Alcohol. Clin. Exp. Res. 34 2010 1201 1211
87. A. Pfefferbaum, E.V. Sullivan, D.H. Mathalon, P.K. Shear, M.J. Rosenbloom, and K.O. Lim Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics Alcohol. Clin. Exp. Res. 19 1995 1177 1191
88. A. Pfefferbaum, E.V. Sullivan, M.J. Rosenbloom, D.H. Mathalon, and K.O. Lim A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval Arch. Gen. Psychiatry 55 1998 905 912
89. V.A. Ramchandani, J. Bolane, T.K. Li, and S. O'Connor A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping Alcohol. Clin. Exp. Res. 23 1999 617 623
90. V.A. Ramchandani, J. Umhau, F.J. Pavon, V. Ruiz-Velasco, W. Margas, H. Sun, R. Damadzic, R. Eskay, M. Schoor, A. Thorsell, M.L. Schwandt, W.H. Sommer, D.T. George, L.H. Parsons, P. Herscovitch, D. Hommer, and M. Heilig A genetic determinant of the striatal dopamine response to alcohol in men Mol. Psychiatry 16 2011 809 817
91. B. Reynolds, J.B. Richards, and H. de Wit Acute-alcohol effects on the Experiential Discounting Task (EDT) and a question-based measure of delay discounting Pharmacol. Biochem. Behav. 83 2006 194 202
92. E. Rickenbacher, D.N. Greve, S. Azma, J. Pfeuffer, and K. Marinkovic Effects of alcohol intoxication and gender on cerebral perfusion: an arterial spin labeling study Alcohol 45 2011 725 737
93. K.R. Ridderinkhof, Y. de Vlugt, A. Bramlage, M. Spaan, M. Elton, J. Snel, and G.P. Band Alcohol consumption impairs detection of performance errors in mediofrontal cortex Science 298 2002 2209 2211
94. K.R. Ridderinkhof, M. Ullsperger, E.A. Crone, and S. Nieuwenhuis The role of the medial frontal cortex in cognitive control Science 306 2004 443 447
95. J.D. Salamone, M. Correa, S. Mingote, and S.M. Weber Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse J. Pharmacol. Exp. Ther. 305 2003 1 8
96. M. Sano, P.E. Wendt, A. Wirsen, G. Stenberg, J. Risberg, and D.H. Ingvar Acute effects of alcohol on regional cerebral blood flow in man J. Stud. Alcohol 54 1993 369 376
97. M.A. Schuckit, T.L. Smith, G.P. Danko, J. Pierson, V. Hesselbrock, K.K. Bucholz, J. Kramer, S. Kuperman, C. Dietiker, R. Brandon, and G. Chan The ability of the Self-Rating of the Effects of Alcohol (SRE) scale to predict alcohol-related outcomes five years later J. Stud. Alcohol Drugs 68 2007 371 378
98. T. Schulte, E.M. Muller-Oehring, A. Pfefferbaum, and E.V. Sullivan Neurocircuitry of emotion and cognition in alcoholism: contributions from white matter fiber tractography Dialogues Clin. Neurosci. 12 2010 554 560
99. E. Seifritz, D. Bilecen, D. Hanggi, R. Haselhorst, E.W. Radu, S. Wetzel, J. Seelig, and K. Scheffler Effect of ethanol on BOLD response to acoustic stimulation: implications for neuropharmacological fMRI Psychiatry Res. 99 2000 1 13
100. S.M. Smith, K.L. Miller, S. Moeller, J. Xu, E.J. Auerbach, M.W. Woolrich, C.F. Beckmann, M. Jenkinson, J. Andersson, M.F. Glasser, D.C. Van Essen, D.A. Feinberg, E.S. Yacoub, and K. Ugurbil Temporally-independent functional modes of spontaneous brain activity Proc. Natl. Acad. Sci. U. S. A. 109 2012 3131 3136
101. C.S. Sripada, M. Angstadt, P. McNamara, A.C. King, and K.L. Phan Effects of alcohol on brain responses to social signals of threat in humans Neuroimage 55 2011 371 380
102. V. Srivastava, B. Buzas, R. Momenan, G. Oroszi, A.J. Pulay, M.A. Enoch, D.W. Hommer, and D. Goldman Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics Neuropsychopharmacology 35 2010 1120 1128
103. E.A. Stein, J. Pankiewicz, H.H. Harsch, J.K. Cho, S.A. Fuller, R.G. Hoffmann, M. Hawkins, S.M. Rao, P.A. Bandettini, and A.S. Bloom Nicotine-induced limbic cortical activation in the human brain: a functional MRI study Am. J. Psychiatry 155 1998 1009 1015
104. E.V. Sullivan, and A. Pfefferbaum Neuroimaging of the Wernicke-Korsakoff syndrome Alcohol Alcohol. 44 2009 155 165
105. E.V. Sullivan, M.J. Rosenbloom, and A. Pfefferbaum Pattern of motor and cognitive deficits in detoxified alcoholic men Alcohol. Clin. Exp. Res. 24 2000 611 621
106. N.J. Tolentino, C.E. Wierenga, S. Hall, S.F. Tapert, M.P. Paulus, T.T. Liu, T.L. Smith, and M.A. Schuckit Alcohol effects on cerebral blood flow in subjects with low and high responses to alcohol Alcohol. Clin. Exp. Res. 35 2011 1034 1040
107. D.C. Van Essen, K. Ugurbil, E. Auerbach, D. Barch, T.E. Behrens, R. Bucholz, A. Chang, L. Chen, M. Corbetta, S.W. Curtiss, S. Della Penna, D. Feinberg, M.F. Glasser, N. Harel, A.C. Heath, L. Larson-Prior, D. Marcus, G. Michalareas, S. Moeller, R. Oostenveld, S.E. Petersen, F. Prior, B.L. Schlaggar, S.M. Smith, A.Z. Snyder, J. Xu, and E. Yacoub The Human Connectome Project: a data acquisition perspective Neuroimage 62 2012 2222 2231
108. N.D. Volkow, R. Hitzemann, A.P. Wolf, J. Logan, J.S. Fowler, D. Christman, S.L. Dewey, D. Schlyer, G. Burr, and S. Vitkun et al. Acute effects of ethanol on regional brain glucose metabolism and transport Psychiatry Res. 35 1990 39 48
109. N.D. Volkow, S.W. Kim, G.J. Wang, D. Alexoff, J. Logan, L. Muench, C. Shea, F. Telang, J.S. Fowler, C. Wong, H. Benveniste, and D. Tomasi Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain Neuroimage 64 2013 277 283
110. N.D. Volkow, Y. Ma, W. Zhu, J.S. Fowler, J. Li, M. Rao, K. Mueller, K. Pradhan, C. Wong, and G.J. Wang Moderate doses of alcohol disrupt the functional organization of the human brain Psychiatry Res. 162 2008 205 213
111. N.D. Volkow, N. Mullani, L. Gould, S.S. Adler, R.W. Guynn, J.E. Overall, and S. Dewey Effects of acute alcohol intoxication on cerebral blood flow measured with PET Psychiatry Res. 24 1988 201 209
112. N.D. Volkow, G.J. Wang, D. Franceschi, J.S. Fowler, P.P. Thanos, L. Maynard, S.J. Gatley, C. Wong, R.L. Veech, G. Kunos, and T. Kai Li Low doses of alcohol substantially decrease glucose metabolism in the human brain Neuroimage 29 2006 295 301
113. N.D. Volkow, G.J. Wang, F. Telang, J.S. Fowler, J. Logan, M. Jayne, Y. Ma, K. Pradhan, and C. Wong Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement J. Neurosci. 27 2007 12700 12706
114. G.J. Wang, N.D. Volkow, J.S. Fowler, D. Franceschi, C.T. Wong, N.R. Pappas, N. Netusil, W. Zhu, C. Felder, and Y. Ma Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects Alcohol. Clin. Exp. Res. 27 2003 909 917
115. G.J. Wang, N.D. Volkow, D. Franceschi, J.S. Fowler, P.K. Thanos, N. Scherbaum, N. Pappas, C.T. Wong, R.J. Hitzemann, and C.A. Felder Regional brain metabolism during alcohol intoxication Alcohol. Clin. Exp. Res. 24 2000 822 829
116. D. Wilkinson, and P. Halligan The relevance of behavioural measures for functional-imaging studies of cognition Nat. Rev. Neurosci. 5 2004 67 73
117. P.H. Yeh, K. Simpson, T.C. Durazzo, S. Gazdzinski, and D.J. Meyerhoff Tract-Based Spatial Statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational neurocircuitry Psychiatry Res. 173 2009 22 30
118. K.K. Yoder, C.C. Constantinescu, D.A. Kareken, M.D. Normandin, T.E. Cheng, S.J. O'Connor, and E.D. Morris Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study Alcohol. Clin. Exp. Res. 31 2007 965 973
119. N.M. Zahr, K.L. Kaufman, and C.G. Harper Clinical and pathological features of alcohol-related brain damage Nat. Rev. Neurol. 7 2011 284 294
120. N.M. Zahr, D. Mayer, T. Rohlfing, J. Orduna, R. Luong, E.V. Sullivan, and A. Pfefferbaum A mechanism of rapidly reversible cerebral ventricular enlargement independent of tissue atrophy Neuropsychopharmacology 38 6 2013 1121 1129
121. R.W. Zoethout, W.L. Delgado, A.E. Ippel, A. Dahan, and J.M. van Gerven Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers Br. J. Clin. Pharmacol. 71 2011 331 350