Alcohol activates the cerebral reward system in man

Journal of Studies on Alcohol

Volumn 59, Issue 3, 1998, Pages 258-269

  Ingvar, M ^a   Ghatan, P H ^a   Wirsen Meurling A ^a,b   Risberg, J ^a,b   Von Heijne, G ^a   Stone Elander, S ^a   Ingvar, D H ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BUTANOL; OXYGEN 15;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BRAIN BLOOD FLOW; BRAIN STEM; CEREBELLUM; CINGULATE GYRUS; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MAZE TEST; NEOCORTEX; NORMAL HUMAN; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; RETICULAR FORMATION; REWARD; TEMPORAL LOBE;

EID: 0031901629     PISSN: 0096882X     EISSN: None     Source Type: Journal    
DOI: 10.15288/jsa.1998.59.258     Document Type: Article

References (52)

1. BENCH, C.J., FRITH, C.D., GRASBY, P.M., FRISTON, K.J., PAULESU, E., FRACKOWIAK, R.S. AND DOLAN, R.J. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia 31: 907-922, 1993.
2. BERGSTRÖM, M., BOETHIUS, J., ERIKSSON, L., GREITZ, T., RIBBE, T. AND WIDEN, L. Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J. Comp. Assist. Tomogr. 5: 136-141, 1981.
3. BERRIDGE, M.S., CASSIDY, E.H. AND TERRIS, A.H. A routine, automated synthesis of oxygen-15-labeled butanol for positron tomography. J. Nucl. Med. 31: 1727-1731, 1990.
4. BRODIE, M.S., SHEFNER, S.A. AND DUNWIDDE, T.V. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res. 508: 65-69, 1990.
5. CHANDLER, L.J., SUMNERS, C. AND CREWS, F.T. Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcsm Clin. Exp. Res. 17: 54-60, 1993.
6. CHILDRESS, A., MCELGIN, W., MOZLEY, D., REIVICH, M. AND O'BRIEN, C. Brain correlates of cue-induced cocaine and opiate craving. Soc. Neurosci. Abstr. 22: 933, 1996.
7. 2-stimulated breathing in man. J. Physiol. 488: 77-84, 1995.
8. DREVETS, W.C., BURTON, H., VIDEEN, T.O., SNYDER, A.Z., SIMPSON, J.R., JR. AND RAICHLE, M.E. Blood flow changes in human somatosensory cortex during anticipated stimulation. Nature 373: 249-252, 1995.
9. ENGEL, J.A., ENERBACK, C., FAHLKE, C., HULTHE, P., HARD, E., JOHANNESSEN, K., SVENSSON, L. AND SÖDERPALM, B. Serotonergic and dopaminergic involvement in ethanol intake. In: NARANJO, C.A. AND SELLERS, E.M. (Eds.) Novel Pharmacological Interventions for Alcoholism, New York: Springer-Verlag, 1992, pp. 68-82.
10. FRISTON, K.J., ASHBURNER, J., FRITH, C.D., POLINE, J.B., HEATHER, J.D. AND FRACKOWIAK, R.S.J. Spatial registration and normalization of images. Human Brain Mapp. 3: 165-189, 1995a.
11. FRISTON, K.J., FRITH, C.D., LIDDLE, P.F., DOLAN, R.J., LAMMERTSMA, A.A. AND FRACKOWIAK, R.S. The relationship between global and local changes in PET scans. J. Cereb. Blood Flow Metab. 10: 458-466, 1990.
12. FRISTON, K.J., FRITH, C.D., LIDDLE, P.F. AND FRACKOWIAK, R.S. Comparing functional (PET) images: The assessment of significant change. J. Cereb. Blood Flow Metab. 11: 690-699, 1991.
13. FRISTON, K.J., HOLMES, A.P., WORSLEY, K.J., POLINE, J.-P. AND FRACKOWIAK, R.S.J. Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapp. 2: 189-210, 1995b.
14. FRISTON, K.J., WORSELY, K.J., FRACKOWIAK, R.S.J., MAZZIOTTA, J.C. AND EVANS, A.C. Assessing the significance of focal activations using their spatial extent. Human Brain Mapp. 1: 214-220, 1994.
15. 15O PET study of the stroop and an emotional stroop. Human Brain Mapp. 1: 194-209, 1994.
16. GHATAN, P.H., HSIEH, J.-C., WIRSÉN-MEURLING, A., WREDLING, R., ERIKSSON, L., STONE-ELANDER, S., LEVANDER, S. AND INGVAR, M. Brain activation induced by the perceptual maze test: A PET study of cognitive performance. Neuroimage 2: 112-124, 1995.
17. GHATAN, P.H., INGVAR, D.H., STONE-ELANDER, S., INGVAR, M. Serial Seven, an arithmetical test of working memory and attention: A PET study. Neuroimage 3: S179, 1996.
18. GREITZ, T., BOHM, C., HOLTE, S. AND ERIKSSON, L. A computerized brain atlas: Construction, anatomical content and some applications. J. Comp. Assist. Tomogr. 15: 26-38, 1991.
19. HADJI-DIMO, A.A. EKBERG, R. AND INGVAR, D.H. Effects of ethanol on EEG and cortical blood flow in the cat. Q.J. Stud. Alcohol 29: 828-838, 1968.
20. HINDMARCH, I. A repeated dose comparison of three benzodiazepine derivatives (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night-time medication. Acta Psychiat. Scand. 56: 373-381, 1977.
21. HSIEH, J.-C., BELFRAGE, M., HANSSON, P., STONE-ELANDER, S. AND INGVAR, M. Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain 63: 225-236, 1995a.
22. HSIEH, J.-C., HANNERZ, J. AND INGVAR, M. Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. Pain 67: 59-68, 1996.
23. HSIEH, J., STONE-ELANDER, S., ERIKSSON, L. AND INGVAR, M. Decreased limbic and primary sensory cortical activity during anticipation and endurance of a painful stimulation. Human Brain Mapp. 2: S165, 1995b.
24. HYATT, M.C. AND TYCE, G.M. The effects of ethanol on the efflux and release of norepinephrine and 5-hydroxytryptamine from slices of rat hypothalamus. Brain Res. 337: 255-262, 1985.
25. 15O)butanol and positron emission tomography. J. Cereb. Blood Flow Metal. 14: 628-638, 1994.
26. INGVAR, M., GHATAN, P., ERIKSSON, L., STONE-ELANDER, S., SERRANDER, S., EKBERG, K. AND WAHREN, J. Nicotine abstinence affects the cerebral attention system. Human Brainmapp. 2: S261, 1995.
27. KOOB, G.F. AND BLOOM, F.E. Cellular and molecular mechanisms of drug dependence. Science 242: 715-723, 1988.
28. KOOB, G.F., RASSNIK, S., HEINRICHS, S. AND WEISS, F. Alcohol, the reward system and dependence. EXS 71: 103-114, 1994.
29. KOOB, G.F. AND WEISS, F. Neuropharmacology of cocaine and ethanol dependence. Rec. Devel. Alcsm. 10: 201-233, 1992.
30. KUPFERMAN, I. Hypothalamus and the limbic system: Motivation. In: KANDEL, E.R., SCHWARTZ, J.H. AND JESSELL, T.M. (Eds.) Principles of Neural Science, 3rd Edition, New York: Elsevier Science Publishing Co., Inc., 1991, pp. 751-760.
31. LOGIE, R.H., GILHOOLY, K.J. AND WYNN, V. Counting on working memory in arithmetic problem solving. Mem. Cognit. 22: 395-410, 1994.
32. LUKAS, S.E., MENDELSON, J.H., WOOD, B.T., MELLO, N.K. AND TEOH, S.K. Topographic distribution of EEG alpha activity during ethanol-induced intoxication in women. J. Stud. Alcohol 50: 176-185, 1989.
33. MATHEW, R.J. AND WILSON, W.H. Regional cerebral blood flow changes associated with ethanol intoxication. Stroke 17: 1156-1159, 1986.
34. MEYER, R.E. What for, alcohol research? (editorial). Amer. J. Psychiat. 151: 165-168, 1994.
35. MORUZZI, G. AND MAGOUN, H.W. Brain stem reticular activation of the EEG. Electroencephalogr. Clin. Neurophysiol. 1: 455-473, 1949.
36. NYLANDER, I., HYYTIÄ, P., FORSANDER, O. AND TERENIUS, L. Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems. Alcsm Clin. Exp. Res. 18: 1272-1279, 1994.
37. OLDS, J. Brain stimulation and the motivation of behavior. Prog. Brain. Res. 45: 401-426, 1976.
38. PAPEZ, J. A proposed mechanism of emotion. Arch. Neurol. 73: 725-743, 1937.
39. REID, L.D., HUBBELL, C.L., GLACCUM, M.B., BILSKY, E.J., PORTOGHESE, P.S. AND PORRECA, F. Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation. Life Sci. 52(9): PL67-71, 1993.
40. RITZ, M.C., KUHAR, M.J. AND GEORGE, F.R. Molecular mechanisms associated with cocaine effects: Possible relationships with effects of ethanol. Rec. Devel. Alcsm 10: 273-302, 1992.
41. SANO, M., WENDT, P.E. WIRSÉN, A., STENBERG, G., RISBERG, J. AND INGVAR, D.H. Acute effects of alcohol on regional cerebral blood flow in man. J. Stud. Alcohol 54: 369-376, 1993.
42. SCHWARTZ, J.A., SPEED, N.M., GROSS, M.D., LUCEY, M.R., BAZAKIS, A.M. HARIHARAN, M. AND BERESFORD, T.P. Acute effects of alcohol administration on regional cerebral blood flow: The role of acetate. Alcsm Clin. Exp. Res. 17: 1119-1123, 1993.
43. STENBERG, G., SANO, M., ROSÉN, I. AND INGVAR, D. EEG topography of acute ethanol effects in resting and activated normals. J. Stud. Alcohol 55: 645-656, 1994.
44. STERIADE, M. Arousal: Revisiting the reticular activating system. Science 272: 225-226, 1996.
45. TALAIRACH, J. AND TOURNOUX, P. Co-Planar Stereotaxic Atlas of the Human Brain. 3-Dimensional Proportional System: An Approach to Medical Cerebral Imaging, New York: Thieme Medical Publishers, 1988.
46. TIIHONEN J., KUIKKA, J., HAKOLA, P., PAANILA, J., AIRAKSINEN, J., ERONEN, M, AND HALLIKAINEN, T. Acute ethanol-induced changes in cerebral blood flow. Amer. J. Psychiat. 151: 1505-1508, 1994.
47. VOLKOW, N.D., HITZEMANN, R., WOLF, A.P., LOGAN, J., FOWLER, J.S., CHRISTMAN, D., DEWEY, S.L., SCHLYER, D., BURR, G., VITKUN, S. AND HIRSCHOWITZ, J. Acute effects of ethanol on regional brain glucose metabolism and transport. Psychiat. Res. 35: 39-48, 1990.
48. WENDT, P.E., RISBERG, J., STENBERG, G., ROSÉN, I. AND INGVAR, D.H. Ethanol reduces asymmetry of visual rCBF responses. J. Cereb. Blood Flow Metab. 14: 963-973, 1994.
49. WIENHARD, K., DAHLBOM, M., ERIKSSON, L., MICHEL, C., BRUCKBAUER, T., PIETRZYK, U. AND HEISS, W.-D. The ECAT EXACT HR: Performance of a new high resolution positron scanner. J. Comp. Assist. Tomogr. 18: 110-118, 1994.
50. WILCE, P.A., LE, F., MATSUMOTO, I. AND SHANLEY, B.C. Ethanol inhibits NMDA-receptor mediated regulation of immediate early gene expression. Alcohol Alcsm Suppl. No. 2: 359-363, 1993.
51. WORSLEY, K.J., EVANS, A.C., MARRETT, S. AND NEELIN, P. A three-dimensional statistical analysis for CBF activation studies in human brain. J. Cereb. Blood Flow Metab. 12: 900-918, 1992.
52. WOZNIAK, K.M. AND LINNOILA, M. Recent advances in pharmacological research on alcohol. Possible relations with cocaine. Rec. Devel. Alcsm 10: 235-272, 1992.