Regional brain metabolism during alcohol intoxication

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 6, 2000, Pages 822-829

  Wang, Gene Jack ^a   Volkow, Nora D ^a   Franceschi, Dinko ^a   Fowler, Joanna S ^a   Thanos, Panayotis K ^b   Scherbaum, Nobert ^c   Pappas, Naomi ^a   Wong, Christopher T ^a   Hitzemann, Robert J ^b   Felder, Christoph A ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Alcohol; Benzodiazepines; Cerebral Glucose Metabolism; Statistical Parametric Mapping; F 18 Fluorodeoxyglucose

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ALCOHOL; GLUCOSE; LORAZEPAM;

ADULT; ALCOHOL INTOXICATION; ARTICLE; BASAL GANGLION; BRAIN METABOLISM; GABAERGIC TRANSMISSION; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OCCIPITAL CORTEX; PRIORITY JOURNAL; SEDATION; TEMPORAL CORTEX; THALAMUS;

EID: 0033932367     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02061.x     Document Type: Article

References (47)

1. Abadie P, Rioux P, Scatton B, Zarifian E, Barre L, Patat A, Baron JC (1996) Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography. Eur J Pharmacol 295:35-44.
2. Amalric M, Koob GF (1993) Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system. Prog Brain Res 99:209-226.
3. Anton RF (1996) Neurobehavioural basis for the pharmacotherapy of alcoholism: Current and future directions. Alcohol Alcohol (Suppl 1) 31:43-53.
4. Bartlett EJ, Brodie JD, Wolf AP, Christman DR, Laska E, Meissner M (1988) Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab 8:502-512.
5. Beauregard M, Leroux JM, Bergman S, Arzoumanian Y, Beaudoin G, Bourgouin P, Stip E (1998) The functional neuroanatomy of major depression: An fMRI study using an emotional activation paradigm. Neuroreport 9:3253-3258.
6. Brogden RN, Goa KL (1988) Flumazenil: A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use. Drugs 35:448-467.
7. Buchsbaum M, Wu J, Haier R, Hazlett E, Ball R, Katz M, Sokolski K, Lagunas-Solar M, Langer D (1987) Positron emission tomography, assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder. Life Sci 40:2393-2400.
8. Davidson RJ (1992) Anterior cerebral asymmetry and the nature of emotion. Brain Cogn 20:125-151.
9. Davidson RJ, Kalin NH, Shelton SE (1992) Lateralized effects of diazepam on frontal brain electrical asymmetries in rhesus monkeys. Biol Psychiatry 32:438-451.
10. De Wit H, Metz J, Wagner N, Cooper M (1990) Behavioral and subjective effects of ethanol: Relationship to cerebral metabolism using PET. Alcohol Clin Exp Res 14:482-489.
11. De Wit H, Metz J, Wagner N, Cooper M (1991) Effects of diazepam on cerebral metabolism and mood in normal volunteers. Neuropsychopharmacology 5:33-41.
12. Di Chiara G, Acquas E, Tanda G (1996) Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link. Alcohol 13:13-17.
13. Fitzgerald LW, Nestler EJ (1995) Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin Neurosci 3:165-173.
14. Garcia C, Philippot P, Lacarelle B, Valli M, Rime B, Bruguerolle B, Blin O (1997) Effects of lorazepam on film-induced differentiated emotions in healthy volunteers. Fundam Clin Pharmacol 11:466-475.
15. Glazer WM (1997) Olanzapine and the new generation of antipsychotic agents: Patterns of use. J Clin Psychiatry (Suppl 10) 58:18-21.
16. Grady CL, Berg G, Carson RE, Daube-Witherspoon ME, Friedland RP, Rapoport SI (1989) Quantitative comparison of cerebral glucose metabolic rates from two positron emission tomographs. J Nucl Med 30: 1386-1392.
17. Grunwald F, Schrock H, Biersack H-J, Kuschinsky W (1993) Changes in local cerebral glucose utilization in the awake rat during acute and chronic administration of ethanol. J Nucl Med 34:793-798.
18. Haiz WL (1973) Statistics for the Social Sciences. Holt Reinhart & Winston, New York.
19. Holman RB, Snape BM, Widdowson PS (1987) Naloxone elicits dose-dependent changes in alcohol-induced increases in endogenous dopamine release from rat striatum. Alcohol Alcohol Suppl 1:737-741.
20. Ingvar M, Ghatan PH, Wirsen-Meurling A, Risberg J, Von Heijne G, Stone-Elander S, Ingvar DH (1998) Alcohol activates the cerebral reward system in man. J Stud Alcohol 59:258-269.
21. 11C]Ro15-4513 in human brain measured with PET. Neurosci Lett 145:133-136.
22. Lewis MJ (1996) Alcohol reinforcement and neuropharmacological therapeutics. Alcohol Alcohol (Suppl 1) 31:17-25.
23. Lloyd BP, Burrin P, Smythe P, Alberti KGMM (1978) Enzymatic fluorometric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutrate. Clin Chem 24:1724-1729.
24. London ED, Broussolle EP, Links JM, Wong DF, Cascella NG, Dannals RF, Sano M, Herning R, Snyder FR, Rippetoe LR (1990) Morphine-induced metabolic changes in human brain. Studies with positron emission tomography and [fluorine-18]fluorodeoxyglucose. Arch Gen Psychiatry 47:73-81.
25. Mennini T, Gobbi M (1990) Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: An evaluation. Eur J Pharmacol 189:143-148.
26. Morrow AL, Paul SM (1988) Benzodiazepine enhancement of γ aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes. J Neurochem 50:302-306.
27. Newman J (1995) Thalamic contributions to attention and consciousness. Conscious Cogn 4:172-193.
28. Pare D, Llinas R (1995) Conscious and pre-conscious processes as seen from the standpoint of sleep-waking cycle neurophysiology. Neuropsychologia 33:1155-1168.
29. Phillips TJ, Shen EH (1996) Neurochemical bases of locomotion and ethanol stimulant effects. Int Rev Neurobiol 39:243-282.
30. Robbins TW, Everitt BJ (1996) Neurobehavioural mechanisms of reward and motivation. Curr Opin Neurobiol 6:228-236.
31. Sprengelmeyer R, Rausch M, Eysel UT, Przuntek H (1931) Neural structures associated with recognition of facial expressions of basic emotions. Proc R Soc Lond B Biol Sci 265:1927-1998.
32. Streeter CC, Ciraulo DA, Harris GJ, Kaufman MJ, Lewis RF, Knapp CM, Ciraulo AM, Maas LC, Ungeheuer M, Szulewski S, Renshaw PF (1998) Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. Psychiatry Res 82:69-82.
33. Talairach J, Tournoux P (1988) A Co-planar Stereotaxic Atlas of a Human Brain. Thieme, New York.
34. Tyrer P (1993) Benzodiazepine dependence: A shadowy diagnosis. Biochem Soc Symp 59:107-119.
35. Volkow ND, Brodie JD, Wolf AP, Gomez-Mont F, Cancero R, Van Gelder P, Russell JAG, Overall J (1986) Brain organization of schizophrenics. J Cereb Blood Flow Metab 6:441-446.
36. Volkow ND, Hitzemann R, Wolf AP, Logan J, Fowler JS, Christman D, Dewey SL, Schlyer D, Burr G, Vitkun S, Hirschowitz J (1990) Acute effects of ethanol on regional brain glucose metabolism and transport. Psychiatry Res 35:39-48.
37. Volkow ND, Wang G-J, Begleiter H, Hitzemann R, Pappas N, Burr G, Pascani K, Wong C, Fowler JS, Wolf AP (1995a) Regional brain metabolic response to lorazepam in subjects at risk for alcoholism. Alcohol Clin Exp Res 19:510-516.
38. Volkow ND, Wang G-J, Fowler JS, Hitzemann R, Galley SJ, Dewey SL, Pappas N (1998) Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: A PET study. Am J Psychiatry 155:200-206.
39. Volkow ND, Wang G-J, Hitzemann R, Fowler JS, Pappas N, Lowrimore P, Burr G, Pascani K, Overall J, Wolf AP (1995b) Depression of thalamic metabolism by lorazepam is associated with sleepiness. Neuropsychopharmacology 12:123-132.
40. Volkow ND, Wang G-J, Hitzemann RJ, Fowler JS, Wolf AP, Pappas N, Biegon A, Dewey SL (1993) Decreased cerebral response to inhibitory neurotransmission in alcoholics. Am J Psychiatry 150:417-422.
41. Wang G-J, Volkow ND, Hitzemann RJ, Pappas NR, Pascani K, Fowler JS (1996) Reproducibility of regional brain metabolic responses to lorazepam. J Nucl Med 37:1609-1613.
42. Wang G-J, Volkow ND, Levy A, Felder CA, Fowler JS, Pappas NR, Hitzemann RJ, Wong CT (1999) Measuring reproducibility of regional brain metabolic responses to lorazepam using statistical parametric maps (SPM). J Nucl Med 40:715-720.
43. Wang G-J, Volkow ND, Wolf AP, Brodie JD, Hitzemann RJ (1994) Intersubjects variability of brain glucose metabolic measurements in young normal males. J Nucl Med 35:1457-1466.
44. Weight FF, Aguayo LG, White G, Lovinger DM, Peoples RW (1992) GABA- and glutamate-gated ion channels as molecular sites of alcohol and anesthetic action. Adv Biochem Psychopharmacol 47:335-347.
45. Woods JH, Katz JL, Winger G (1992a) Benzodiazepines: Use, abuse and consequences. Pharmacol Rev 44:151-347.
46. 123I]iomazenil in healthy human subjects. Psychiatry Res 45:67-77.
47. Zarate CA Jr, Narendran R, Tonen M, Greaney JJ, Berman A, Pike S, Madrid A (1998) Clinical predictors of acute response with olanzapine in psychotic mood disorders. J Clin Psychiatry 59:24-28.