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Volumn 122, Issue 18, 2013, Pages 3116-3121

Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL POPULATION; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL TRIAL (TOPIC); DIFFUSE LARGE B CELL LYMPHOMA; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MYELOABLATIVE CONDITIONING; NATURAL KILLER T CELL; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRE T LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ANIMAL; BIOLOGICAL MODEL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNOLOGY; PROCEDURES; METHODOLOGY; REVIEW;

EID: 84891590554     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-08-453126     Document Type: Article
Times cited : (72)

References (88)
  • 1
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775-787.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 2
    • 0346690399 scopus 로고    scopus 로고
    • Recipienttype specific CD41CD251 regulatory T cells favor immune reconstitution and control graftversus-host disease while maintaining graftversus-leukemia
    • Trenado A, Charlotte F, Fisson S, et al. Recipienttype specific CD41CD251 regulatory T cells favor immune reconstitution and control graftversus-host disease while maintaining graftversus-leukemia. J Clin Invest. 2003;112(11): 1688-1696.
    • (2003) J Clin Invest. , vol.112 , Issue.11 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155(3): 1151-1164.
    • (1995) J Immunol. , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609): 1057-1061.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 5
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001; 27(1):68-73.
    • (2001) Nat Genet. , vol.27 , Issue.1 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 6
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27(1): 20-21.
    • (2001) Nat Genet. , vol.27 , Issue.1 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 7
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001; 27(1):18-20.
    • (2001) Nat Genet. , vol.27 , Issue.1 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 8
    • 51049101255 scopus 로고    scopus 로고
    • CD41 FoxP31 regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    • Andersson J, Tran DQ, Pesu M, et al. CD41 FoxP31 regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med. 2008;205(9):1975-1981.
    • (2008) J Exp Med. , vol.205 , Issue.9 , pp. 1975-1981
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3
  • 9
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450(7169):566-569.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 10
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(1)CD25(1) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(1)CD25(1) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194(5):629-644.
    • (2001) J Exp Med. , vol.194 , Issue.5 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 12
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28(4):546-558.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 13
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for regulatory T cellmediated suppression of tumor clearance
    • Cao X, Cai SF, Fehniger TA, et al. Granzyme B and perforin are important for regulatory T cellmediated suppression of tumor clearance. Immunity. 2007;27(4):635-646.
    • (2007) Immunity , vol.27 , Issue.4 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3
  • 14
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204(6):1257-1265.
    • (2007) J Exp Med. , vol.204 , Issue.6 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 15
    • 13544271161 scopus 로고    scopus 로고
    • Cutting edge: Contact-mediated suppression by CD41CD251 regulatory cells involves a granzyme B-dependent, perforinindependent mechanism
    • Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ. Cutting edge: contact-mediated suppression by CD41CD251 regulatory cells involves a granzyme B-dependent, perforinindependent mechanism. J Immunol. 2005; 174(4):1783-1786.
    • (2005) J Immunol. , vol.174 , Issue.4 , pp. 1783-1786
    • Gondek, D.C.1    Lu, L.F.2    Quezada, S.A.3    Sakaguchi, S.4    Noelle, R.J.5
  • 16
    • 5644238762 scopus 로고    scopus 로고
    • Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
    • Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004;104(9):2840-2848.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2840-2848
    • Grossman, W.J.1    Verbsky, J.W.2    Tollefsen, B.L.3    Kemper, C.4    Atkinson, J.P.5    Ley, T.J.6
  • 17
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity. 2004;21(4): 503-513.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 503-513
    • Huang, C.T.1    Workman, C.J.2    Flies, D.3
  • 18
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp31 regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp31 regulatory T cell function. Science. 2008;322(5899):271-275.
    • (2008) Science , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 19
    • 0037026001 scopus 로고    scopus 로고
    • CD4(1)CD25(1) immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(1)CD25(1) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002;196(3):401-406.
    • (2002) J Exp Med. , vol.196 , Issue.3 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 20
    • 0141461418 scopus 로고    scopus 로고
    • CD41 CD251 regulatory T cells preserve graft-versustumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, et al. CD41 CD251 regulatory T cells preserve graft-versustumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9(9):1144-1150.
    • (2003) Nat Med. , vol.9 , Issue.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 21
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(1)CD25(1) regulatory T cells suppress lethal acute graftversus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(1)CD25(1) regulatory T cells suppress lethal acute graftversus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196(3):389-399.
    • (2002) J Exp Med. , vol.196 , Issue.3 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 22
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(1)CD25(1) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(1)CD25(1) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99(10):3493-3499.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 23
    • 33947203388 scopus 로고    scopus 로고
    • In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
    • Nguyen VH, Zeiser R, Dasilva DL, et al. In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood. 2007;109(6):2649-2656.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2649-2656
    • Nguyen, V.H.1    Zeiser, R.2    Dasilva, D.L.3
  • 24
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(1)CD25high regulatory T cells
    • Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4(1)CD25high regulatory T cells. Blood. 2004;104(3):895-903.
    • (2004) Blood , vol.104 , Issue.3 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 25
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(1)cd4(1) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG. Human cd25(1)cd4(1) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001;193(11):1295-1302.
    • (2001) J Exp Med. , vol.193 , Issue.11 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 26
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD41CD251 FoxP31 regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD41CD251 FoxP31 regulatory T cells. Blood. 2005;105(12): 4743-4748.
    • (2005) Blood , vol.105 , Issue.12 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 27
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    • Hippen KL, Merkel SC, Schirm DK, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med. 2011;3(83): 83ra41.
    • (2011) Sci Transl Med. , vol.3 , Issue.83 , pp. 83ra41
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 28
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA1 subpopulation of CD41CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann P, Eder R, Boeld TJ, et al. Only the CD45RA1 subpopulation of CD41CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood. 2006; 108(13):4260-4267.
    • (2006) Blood , vol.108 , Issue.13 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 29
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD1031 DCs induces Foxp31 regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, et al. A functionally specialized population of mucosal CD1031 DCs induces Foxp31 regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007; 204(8):1757-1764.
    • (2007) J Exp Med. , vol.204 , Issue.8 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Cárcamo, C.V.3
  • 30
    • 15244354491 scopus 로고    scopus 로고
    • De novo generation of antigenspecific CD41CD251 regulatory T cells from human CD41CD25-cells
    • Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH. De novo generation of antigenspecific CD41CD251 regulatory T cells from human CD41CD25-cells. Proc Natl Acad Sci USA. 2005;102(11):4103-4108.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.11 , pp. 4103-4108
    • Walker, M.R.1    Carson, B.D.2    Nepom, G.T.3    Ziegler, S.F.4    Buckner, J.H.5
  • 31
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD41CD25-T cells
    • Walker MR, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD41CD25-T cells. J Clin Invest. 2003;112(9):1437-1443.
    • (2003) J Clin Invest. , vol.112 , Issue.9 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 32
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, Feuerer M, Tash K, et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity. 2007;27(5):786-800.
    • (2007) Immunity , vol.27 , Issue.5 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3
  • 33
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD41FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD41FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood. 2007;110(8):2983-2990.
    • (2007) Blood , vol.110 , Issue.8 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 34
    • 84863360489 scopus 로고    scopus 로고
    • Oligodeoxynucleotides stabilize Heliosexpressing Foxp31 human T regulatory cells during in vitro expansion
    • Kim YC, Bhairavabhotla R, Yoon J, et al. Oligodeoxynucleotides stabilize Heliosexpressing Foxp31 human T regulatory cells during in vitro expansion. Blood. 2012;119(12): 2810-2818.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2810-2818
    • Kim, Y.C.1    Bhairavabhotla, R.2    Yoon, J.3
  • 35
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • Lal G, Bromberg JS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood. 2009; 114(18):3727-3735.
    • (2009) Blood , vol.114 , Issue.18 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 36
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal G, Zhang N, van der Touw W, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol. 2009; 182(1):259-273.
    • (2009) J Immunol. , vol.182 , Issue.1 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der-Touw, W.3
  • 37
    • 78149408519 scopus 로고    scopus 로고
    • Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    • Polansky JK, Schreiber L, Thelemann C, et al. Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med (Berl). 2010;88(10):1029-1040.
    • (2010) J Mol Med (Berl) , vol.88 , Issue.10 , pp. 1029-1040
    • Polansky, J.K.1    Schreiber, L.2    Thelemann, C.3
  • 38
    • 84867899425 scopus 로고    scopus 로고
    • Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp31 T reg cells
    • Weiss JM, Bilate AM, Gobert M, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp31 T reg cells. J Exp Med. 2012;209(10): 1723-1742.
    • (2012) J Exp Med. , vol.209 , Issue.10 , pp. 1723-1742
    • Weiss, J.M.1    Bilate, A.M.2    Gobert, M.3
  • 39
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • Yadav M, Louvet C, Davini D, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012;209(10):1713-1722.
    • (2012) J Exp Med. , vol.209 , Issue.10 , pp. 1713-1722
    • Yadav, M.1    Louvet, C.2    Davini, D.3
  • 40
    • 34047174849 scopus 로고    scopus 로고
    • Activationinduced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • Allan SE, Crome SQ, Crellin NK, et al. Activationinduced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007;19(4):345-354.
    • (2007) Int Immunol. , vol.19 , Issue.4 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3
  • 41
    • 23044463715 scopus 로고    scopus 로고
    • CD41 CD251 regulatory T cells control the induction of antigen-specific CD41 helper T cell responses in cancer patients
    • Nishikawa H, Jäger E, Ritter G, Old LJ, Gnjatic S. CD41 CD251 regulatory T cells control the induction of antigen-specific CD41 helper T cell responses in cancer patients. Blood. 2005;106(3): 1008-1011.
    • (2005) Blood , vol.106 , Issue.3 , pp. 1008-1011
    • Nishikawa, H.1    Jäger, E.2    Ritter, G.3    Old, L.J.4    Gnjatic, S.5
  • 42
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD251CD41 T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD251CD41 T cells: a common basis between tumor immunity and autoimmunity. J Immunol. 1999;163(10): 5211-5218.
    • (1999) J Immunol. , vol.163 , Issue.10 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 43
    • 0242557055 scopus 로고    scopus 로고
    • Posthematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response
    • Jones SC, Murphy GF, Korngold R. Posthematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transplant. 2003; 9(4):243-256.
    • (2003) Biol Blood Marrow Transplant , vol.9 , Issue.4 , pp. 243-256
    • Jones, S.C.1    Murphy, G.F.2    Korngold, R.3
  • 44
    • 78149486215 scopus 로고    scopus 로고
    • A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice
    • Casares N, Rudilla F, Arribillaga L, et al. A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice. J Immunol. 2010;185(9):5150-5159.
    • (2010) J Immunol. , vol.185 , Issue.9 , pp. 5150-5159
    • Casares, N.1    Rudilla, F.2    Arribillaga, L.3
  • 45
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp31 regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K, Mayer CT, Lahl K, et al. Selective depletion of Foxp31 regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 2010;70(20): 7788-7799.
    • (2010) Cancer Res. , vol.70 , Issue.20 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3
  • 46
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117(14):3921-3928.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 47
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117(3): 1061-1070.
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 48
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(1) CD25(1) CD4(1) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3(1) CD25(1) CD4(1) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005;201(5): 723-735.
    • (2005) J Exp Med. , vol.201 , Issue.5 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 49
    • 80052157997 scopus 로고    scopus 로고
    • Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD41 CD251Foxp31 regulatory T cells
    • Shin HJ, Baker J, Leveson-Gower DB, Smith AT, Sega EI, Negrin RS. Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD41 CD251Foxp31 regulatory T cells. Blood. 2011; 118(8):2342-2350.
    • (2011) Blood , vol.118 , Issue.8 , pp. 2342-2350
    • Shin, H.J.1    Baker, J.2    Leveson-Gower, D.B.3    Smith, A.T.4    Sega, E.I.5    Negrin, R.S.6
  • 50
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD41CD251Foxp31 regulatory T cells compared with conventional CD41 T cells
    • Zeiser R, Leveson-Gower DB, Zambricki EA, et al. Differential impact of mammalian target of rapamycin inhibition on CD41CD251Foxp31 regulatory T cells compared with conventional CD41 T cells. Blood. 2008;111(1):453-462.
    • (2008) Blood , vol.111 , Issue.1 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3
  • 51
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD41 CD251 regulatory T cells through a STATdependent mechanism and induces the expansion of these cells in vivo
    • Zorn E, Nelson EA, Mohseni M, et al. IL-2 regulates FOXP3 expression in human CD41 CD251 regulatory T cells through a STATdependent mechanism and induces the expansion of these cells in vivo. Blood. 2006; 108(5):1571-1579.
    • (2006) Blood , vol.108 , Issue.5 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3
  • 52
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • Koreth J, Matsuoka K, Kim HT, et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med. 2011;365(22):2055-2066.
    • (2011) N Engl J Med. , vol.365 , Issue.22 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 53
    • 70249122695 scopus 로고    scopus 로고
    • First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD41CD251CD127-T regulatory cells
    • Trzonkowski P, Bieniaszewska M, Júscińska J, et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD41CD251CD127-T regulatory cells. Clin Immunol. 2009;133(1): 22-26.
    • (2009) Clin Immunol. , vol.133 , Issue.1 , pp. 22-26
    • Trzonkowski, P.1    Bieniaszewska, M.2    Júscińska, J.3
  • 54
    • 0028158319 scopus 로고
    • High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
    • Bacchetta R, Bigler M, Touraine JL, et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med. 1994;179(2):493-502.
    • (1994) J Exp Med. , vol.179 , Issue.2 , pp. 493-502
    • Bacchetta, R.1    Bigler, M.2    Touraine, J.L.3
  • 55
    • 0030704726 scopus 로고    scopus 로고
    • A CD41 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD41 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997; 389(6652):737-742.
    • (1997) Nature , vol.389 , Issue.6652 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 56
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD41CD251 regulatory T cells
    • Vieira PL, Christensen JR, Minaee S, et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD41CD251 regulatory T cells. J Immunol. 2004;172(10):5986-5993.
    • (2004) J Immunol. , vol.172 , Issue.10 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3
  • 57
    • 81155160952 scopus 로고    scopus 로고
    • Type 1 regulatory T cells (Tr1) in autoimmunity
    • Pot C, Apetoh L, Kuchroo VK. Type 1 regulatory T cells (Tr1) in autoimmunity. Semin Immunol. 2011;23(3):202-208.
    • (2011) Semin Immunol. , vol.23 , Issue.3 , pp. 202-208
    • Pot, C.1    Apetoh, L.2    Kuchroo, V.K.3
  • 58
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol. 2007; 7(8):585-598.
    • (2007) Nat Rev Immunol. , vol.7 , Issue.8 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 59
    • 79952202516 scopus 로고    scopus 로고
    • Methods for in vitro generation of human type 1 regulatory T cells
    • Gregori S, Roncarolo MG, Bacchetta R. Methods for in vitro generation of human type 1 regulatory T cells. Methods Mol Biol. 2011;677:31-46.
    • (2011) Methods Mol Biol. , vol.677 , pp. 31-46
    • Gregori, S.1    Roncarolo, M.G.2    Bacchetta, R.3
  • 60
    • 77956538422 scopus 로고    scopus 로고
    • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    • Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood. 2010;116(6): 935-944.
    • (2010) Blood , vol.116 , Issue.6 , pp. 935-944
    • Gregori, S.1    Tomasoni, D.2    Pacciani, V.3
  • 62
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N, Magnani CF, Huber S, et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med. 2013;19(6):739-746.
    • (2013) Nat Med. , vol.19 , Issue.6 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3
  • 63
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct human regulatory T cells
    • Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006;176(8): 4622-4631.
    • (2006) J Immunol. , vol.176 , Issue.8 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 64
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L1 subpopulation of CD41CD251 regulatory T cells protects from lethal acute GVHD
    • Ermann J, Hoffmann P, Edinger M, et al. Only the CD62L1 subpopulation of CD41CD251 regulatory T cells protects from lethal acute GVHD. Blood. 2005;105(5):2220-2226.
    • (2005) Blood , vol.105 , Issue.5 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3
  • 65
    • 33646882230 scopus 로고    scopus 로고
    • Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance
    • Shimoda M, Mmanywa F, Joshi SK, et al. Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. J Immunol. 2006;176(11): 6503-6511.
    • (2006) J Immunol. , vol.176 , Issue.11 , pp. 6503-6511
    • Shimoda, M.1    Mmanywa, F.2    Joshi, S.K.3
  • 66
    • 9444280125 scopus 로고    scopus 로고
    • L-Selectin(hi) but not the L-selectin(lo) CD41251 T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    • Taylor PA, Panoskaltsis-Mortari A, Swedin JM, et al. L-Selectin(hi) but not the L-selectin(lo) CD41251 T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood. 2004; 104(12):3804-3812.
    • (2004) Blood , vol.104 , Issue.12 , pp. 3804-3812
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Swedin, J.M.3
  • 67
    • 32644459908 scopus 로고    scopus 로고
    • Antigenspecific regulatory T cells-ex vivo expansion and therapeutic potential
    • Masteller EL, Tang Q, Bluestone JA. Antigenspecific regulatory T cells-ex vivo expansion and therapeutic potential. Semin Immunol. 2006; 18(2):103-110.
    • (2006) Semin Immunol. , vol.18 , Issue.2 , pp. 103-110
    • Masteller, E.L.1    Tang, Q.2    Bluestone, J.A.3
  • 68
    • 2942642383 scopus 로고    scopus 로고
    • In vitroexpanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, et al. In vitroexpanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004; 199(11):1455-1465.
    • (2004) J Exp Med. , vol.199 , Issue.11 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 69
    • 81555214616 scopus 로고    scopus 로고
    • Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
    • Veerapathran A, Pidala J, Beato F, Yu XZ, Anasetti C. Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. Blood. 2011;118(20):5671-5680.
    • (2011) Blood , vol.118 , Issue.20 , pp. 5671-5680
    • Veerapathran, A.1    Pidala, J.2    Beato, F.3    Yu, X.Z.4    Anasetti, C.5
  • 70
    • 84881265208 scopus 로고    scopus 로고
    • A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graftversus-host disease
    • Meyer EH, Hsu AR, Liliental J, et al. A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graftversus-host disease. Blood. 2013;121(24): 4955-4962.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4955-4962
    • Meyer, E.H.1    Hsu, A.R.2    Liliental, J.3
  • 73
    • 23244460051 scopus 로고    scopus 로고
    • Host-residual invariant NK T cells attenuate graftversus-host immunity
    • Haraguchi K, Takahashi T, Matsumoto A, et al. Host-residual invariant NK T cells attenuate graftversus-host immunity. J Immunol. 2005;175(2): 1320-1328.
    • (2005) J Immunol. , vol.175 , Issue.2 , pp. 1320-1328
    • Haraguchi, K.1    Takahashi, T.2    Matsumoto, A.3
  • 74
    • 38449096758 scopus 로고    scopus 로고
    • Donor bone marrow type II (non-Valpha14Jalpha18 CD1d-restricted) NKT cells suppress graft-versus-host disease by producing IFN-gamma and IL-4
    • Kim JH, Choi EY, Chung DH. Donor bone marrow type II (non-Valpha14Jalpha18 CD1d-restricted) NKT cells suppress graft-versus-host disease by producing IFN-gamma and IL-4. J Immunol. 2007; 179(10):6579-6587.
    • (2007) J Immunol. , vol.179 , Issue.10 , pp. 6579-6587
    • Kim, J.H.1    Choi, E.Y.2    Chung, D.H.3
  • 75
    • 79953074487 scopus 로고    scopus 로고
    • Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism
    • Leveson-Gower DB, Olson JA, Sega EI, et al. Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism. Blood. 2011;117(11): 3220-3229.
    • (2011) Blood , vol.117 , Issue.11 , pp. 3220-3229
    • Leveson-Gower, D.B.1    Olson, J.A.2    Sega, E.I.3
  • 76
    • 84860652954 scopus 로고    scopus 로고
    • Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation
    • Chaidos A, Patterson S, Szydlo R, et al. Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. Blood. 2012;119(21):5030-5036.
    • (2012) Blood , vol.119 , Issue.21 , pp. 5030-5036
    • Chaidos, A.1    Patterson, S.2    Szydlo, R.3
  • 77
    • 23044472871 scopus 로고    scopus 로고
    • In vivo analyses of early events in acute graft-versushost disease reveal sequential infiltration of T-cell subsets
    • Beilhack A, Schulz S, Baker J, et al. In vivo analyses of early events in acute graft-versushost disease reveal sequential infiltration of T-cell subsets. Blood. 2005;106(3):1113-1122.
    • (2005) Blood , vol.106 , Issue.3 , pp. 1113-1122
    • Beilhack, A.1    Schulz, S.2    Baker, J.3
  • 78
    • 1542472609 scopus 로고    scopus 로고
    • Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versushost disease: The role of CD1-reactive natural killer T cells
    • Lan F, Zeng D, Higuchi M, Higgins JP, Strober S. Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versushost disease: the role of CD1-reactive natural killer T cells. Biol Blood Marrow Transplant. 2003; 9(6):355-363.
    • (2003) Biol Blood Marrow Transplant , vol.9 , Issue.6 , pp. 355-363
    • Lan, F.1    Zeng, D.2    Higuchi, M.3    Higgins, J.P.4    Strober, S.5
  • 79
    • 66149101300 scopus 로고    scopus 로고
    • Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD41CD251 Foxp31 T regulatory cells that protects against graft-versus-host disease
    • Pillai AB, George TI, Dutt S, Strober S. Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD41CD251 Foxp31 T regulatory cells that protects against graft-versus-host disease. Blood. 2009;113(18): 4458-4467.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4458-4467
    • Pillai, A.B.1    George, T.I.2    Dutt, S.3    Strober, S.4
  • 80
    • 25444461935 scopus 로고    scopus 로고
    • Protective conditioning for acute graft-versus-host disease
    • Lowsky R, Takahashi T, Liu YP, et al. Protective conditioning for acute graft-versus-host disease. N Engl J Med. 2005;353(13):1321-1331.
    • (2005) N Engl J Med. , vol.353 , Issue.13 , pp. 1321-1331
    • Lowsky, R.1    Takahashi, T.2    Liu, Y.P.3
  • 81
    • 70349246939 scopus 로고    scopus 로고
    • TLI and ATG conditioning with low risk of graft-versushost disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
    • Kohrt HE, Turnbull BB, Heydari K, et al. TLI and ATG conditioning with low risk of graft-versushost disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors. Blood. 2009;114(5): 1099-1109.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1099-1109
    • Kohrt, H.E.1    Turnbull, B.B.2    Heydari, K.3
  • 82
    • 84866180721 scopus 로고    scopus 로고
    • Multicenter experience using total lymphoid irradiation and antithymocyte globulin as conditioning for allografting in hematological malignancies
    • Messina G, Giaccone L, Festuccia M, et al; Gruppo Italiano Trapianti di Midollo. Multicenter experience using total lymphoid irradiation and antithymocyte globulin as conditioning for allografting in hematological malignancies. Biol Blood Marrow Transplant. 2012;18(10): 1600-1607.
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.10 , pp. 1600-1607
    • Messina, G.1    Giaccone, L.2    Festuccia, M.3
  • 83
    • 79960209022 scopus 로고    scopus 로고
    • Pharmacologic expansion of donor-derived, naturally occurring CD4(1)Foxp3(1) regulatory T cells reduces acute graft-versushost disease lethality without abrogating the graft-versus-leukemia effect in murine models
    • Duramad O, Laysang A, Li J, Ishii Y, Namikawa R. Pharmacologic expansion of donor-derived, naturally occurring CD4(1)Foxp3(1) regulatory T cells reduces acute graft-versushost disease lethality without abrogating the graft-versus-leukemia effect in murine models. Biol Blood Marrow Transplant. 2011;17(8): 1154-1168.
    • (2011) Biol Blood Marrow Transplant , vol.17 , Issue.8 , pp. 1154-1168
    • Duramad, O.1    Laysang, A.2    Li, J.3    Ishii, Y.4    Namikawa, R.5
  • 84
    • 0037111401 scopus 로고    scopus 로고
    • Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion
    • Higuchi M, Zeng D, Shizuru J, et al. Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion. J Immunol. 2002;169(10): 5564-5570.
    • (2002) J Immunol. , vol.169 , Issue.10 , pp. 5564-5570
    • Higuchi, M.1    Zeng, D.2    Shizuru, J.3
  • 85
    • 0021348233 scopus 로고
    • Induction of specific unresponsiveness to heart allografts in mongrel dogs treated with total lymphoid irradiation and antithymocyte globulin
    • Strober S, Modry DL, Hoppe RT, et al. Induction of specific unresponsiveness to heart allografts in mongrel dogs treated with total lymphoid irradiation and antithymocyte globulin. J Immunol. 1984;132(2):1013-1018.
    • (1984) J Immunol. , vol.132 , Issue.2 , pp. 1013-1018
    • Strober, S.1    Modry, D.L.2    Hoppe, R.T.3
  • 86
    • 38549134052 scopus 로고    scopus 로고
    • Tolerance and chimerism after renal and hematopoietic-cell transplantation
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med. 2008;358(4):362-368.
    • (2008) N Engl J Med. , vol.358 , Issue.4 , pp. 362-368
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 88
    • 84860433872 scopus 로고    scopus 로고
    • Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant. 2012;12(5): 1133-1145.
    • (2012) Am J Transplant , vol.12 , Issue.5 , pp. 1133-1145
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3


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