Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1, 3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 141-147

  Alafeefy, Ahmed M ^a   Abdel Aziz, Hatem A ^b,c   Vullo, Daniela ^d   Al Tamimi, Abdul Malek S ^a   Al Jaber, Nabila A ^e   Capasso, Clemente ^f   Supuran, Claudiu T ^d  

^a PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d UNIVERSITY OF FLORENCE   (Italy)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

^f INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

Alpha class enzyme; Carbonic anhydrase; Extremophiles; Inhibition study; Sulfonamide; Sulfurihydrogenibium spp.

Indexed keywords

2 (2 BENZOYLHYDRAZONO) N' (4 SULFAMOYLPHENYL)PROPANEHYDRAZONOYL CHLORIDE; 2 [2 (4 CHLOROBENZOYL)HYDRAZONO] N' (4 SULFAMOYLPHENYL)PROPANEHYDRAZONOYL CHLORIDE; 2 [2 (4 METHOXYBENZOYL)HYDRAZONO] N' (4 SULFAMOYLPHENYL)PROPANEHYDRAZONOYL CHLORIDE; 2 [5 ACETYL 3 (4 SULFAMOYLPHENYL) 1,3,4 THIADIAZOL 2(3H) YLIDENE] 2 CYANO N (4 SULFAMOYLPHENYL)ACETAMIDE; 4 [2 (3,6 DIMETHYL 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 7 YLIDENE)HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 (6 METHYL 3 PHENYL 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 7 YLIDENE)HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [1 (PIPERIDIN 1 YL) 2 [2 (THINE 2 CARBONYL)HYDRAZONO]PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 BENZOYLHYDRAZONO) 1 (PHENYLSULFONYL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 BENZOYLHYDRAZONO) 1 (PIPERIDIN 1 YL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 CHLOROBENZOYLHYDRAZONO) 1 (PHENYLSULFONYL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 CHLOROBENZOYLHYDRAZONO) 1 (PIPERIDIN 1 YL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 METHOXYBENZOYLHYDRAZONO) 1 (PHENYLSULFONYL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [2 [2 (2 METHOXYBENZOYLHYDRAZONO) 1 (PIPERIDIN 1 YL)PROPYLIDENE]HYDRAZINYL]BENZENE SULFONAMIDE; 4 [5 ACETYL 2 (1 CYANO 2 OXO 2 PHENYLETHYLIDENE) 1,3,4 THIADIAZOL 3(2H) YL]BENZENE SULFONAMIDE; 4 [5 ACETYL 2 (CYANOPHENYLMETHYLENE) 1,3,4 THIADIAZOL 3(2H) YL]BENZENESULFONAMIDE; ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; ETHYL 2 [5 ACETYL 3 (4 SULFAMOYLPHENYL) 1,3,4 THIADIAZOL 2(3H) YLIDENE] 2 CYANOACETATE; HYDRAZONE DERIVATIVE; N' (4 SULFAMOYLPHENYL) 2 [2 (THIOPHENE 2 CARBONYL)HYDRAZONO]PROPANE HYDRAZONOYL CHLORIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; CATALYSIS; CHEMOLITHOTROPH; CONTROLLED STUDY; ENZYME INHIBITION; NONHUMAN; SULFURIHYDROGENIBIUM AZORENSE; SULFURIHYDROGENIBIUM YELLOSTONENSE; THERMOSTABILITY;

BACTERIA (MICROORGANISMS); SULFURIHYDROGENIBIUM; SULFURIHYDROGENIBIUM AZORENSE;

ALPHA-CLASS ENZYME; CARBONIC ANHYDRASE; EXTREMOPHILES; INHIBITION STUDY; SULFONAMIDE; SULFURIHYDROGENIBIUM SPP.;

BACTERIA; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYSIS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84891493579     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.042     Document Type: Article

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