Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells

Molecular and Cellular Biochemistry

Volumn 382, Issue 1-2, 2013, Pages 173-183

  Bishayee, Kausik ^a   Paul, Avijit ^a   Ghosh, Samrat ^a   Sikdar, Sourav ^a   Mukherjee, Avinaba ^a   Biswas, Raktim ^a   Boujedaini, N ^b   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

Apoptosis; Condurango glycoside A; DNA damage; HeLa cells; Senescence

Indexed keywords

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CASPASE 3; CONDURANGO GLYCOSIDE A; CYTOCHROME C; GONOLOBUS CONDURANGO EXTRACT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL AGING; CELL ASSAY; CELL CYCLE ARREST; CONDURANGO; CONTROLLED STUDY; DNA DAMAGE; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GONOLOBUS CONDURANGO; HELA CELL; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

GONOLOBUS; MARSDENIA CONDURANGO;

APOPTOSIS; CELL AGING; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MARSDENIA; MASS SPECTROMETRY; PREGNANES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884673227     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1732-5     Document Type: Article

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