Antihyperglycemic potentials of a threatened plant, Helonias dioica: Antioxidative stress responses and the signaling cascade

Experimental Biology and Medicine

Volumn 237, Issue 1, 2012, Pages 64-76

  Chakraborty, Debrup ^a   Samadder, Asmita ^a   Dutta, Suman ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

Alloxan induced diabetes; Antihyperglycemic potentials; Helonias dioica; Islet cells; Reactive oxygen species; Signaling cascade

Indexed keywords

ALLOXAN; BIOLOGICAL MARKER; CASPASE 3; CATALASE; CYCLOOXYGENASE 2; CYTOCHROME C; DNA; GAMMA INTERFERON; GLUCOKINASE; GLUTATHIONE; GLYCOGEN; HELONIAS DIOICA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPID PEROXIDASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CELL DAMAGE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLYCOGEN SYNTHESIS; HELONIAS DIOICA; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER; LOW DRUG DOSE; MEDICINAL PLANT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET CELL; SCAVENGING SYSTEM; SIGNAL TRANSDUCTION;

ALLOXAN; ANGIOSPERMS; ANIMALS; CASPASE 3; CATALASE; CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOCHROMES C; DNA DAMAGE; ENDANGERED SPECIES; GLUCOKINASE; GLUTATHIONE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; LIPID PEROXIDES; LIVER GLYCOGEN; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

HELONIAS; MUS;

EID: 84855824391     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2011.011161     Document Type: Article

References (52)

1. Horowitz S. Treating infertility, a holistic approach. Altern Complement Ther 2006;12:165-71.
2. Boericke W. Pocket Manual of Homeopathic Material Medica Comprising the Characteristic and Guiding Symptoms of all Remedies (Clinical and Pathogenic). Arjun Nagar, New Delhi: B Jain, 2000
3. Hui H, Tang G, Go VLW. Hypoglycemic herbs and their action mechanisms. Chin Med 2009;4:1-11.
4. Marker RE, Wagner RB, Ulshafer PR. Sterols. CXLVI. Sapogenins. LX. Some new sources of diosgenin. J Am Chem Soc 1942;64:1283-5.
5. Cataline EL, Francke DE. The phytochemistry of Helonias I. Preliminary examination of the drug. J Am Pharm Assoc 1942;31:519-21.
6. Zhang Z, Cui FJ. Non-enzymatic glycosylation reaction contributes to a rise of blood glucose in alloxan-induced diabetic rats. Int J Diabetes Metab 2007;15:52-9.
7. Wild S, Bchir MB, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes, estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
8. Moller D. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 2001;414:821-7.
9. Vijayakumar MV, Singh S, Chhipa RR, Bhat MK. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br J Pharmacol 2005;146:41-8.
10. Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006;104:119-23.
11. Sabu MC, Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol 2002;81:155-60.
12. Pavana P, Monoharan S, Renju GL, Sethupathy S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. J Environ Biol 2007;28:833-7.
13. Kamiya K, Hamabe W, Harada S, Murakami R, Tokuyama S, Satake T. Chemical constituents of Morinda citrifolia roots exhibit hypoglycemic effects in streptozotocin-induced diabetic mice. Biol Pharm Bull 2008;31:935-8.
14. Khuda-Bukhsh AR. Mice as a model for homeopathy research. Homeopathy 2009;98:267-79.
15. Blois MS. Antioxidant determination by use of a stable free radical. Nature 1958;29:1199-200.
16. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 1999;283:981-5.
17. Chang I, Kim S, Kim JY, Cho N, Kim YH, Kim HS, Lee MK, Kim KW, Lee MS. NF-lb prevents b cell death and autoimmune diabetes in NOD mice. Diabetes 2003;52:1169-75.
18. Mandal SK, Biswas R, Bhattacharyya SS, Paul S, Dutta S, Pathak S, Khuda-Bukhsh AR. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol 2009;626:1-8.
19. Ratha J, Majumder KN, Mandal SK, Bera R, Sarkar C, Saha B, Mandal C, Saha KD, Bhadra R. A sphingolipid rich lipid fraction isolated from attenuated donovani promastigote induces apoptosis in mouse and human melanoma cells in vitro. Mol Cell Biochem 2006;290:113-23.
20. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994;l84:1415-20.
21. Yu J, Cui PJ, Zeng WL, Xie XL, Liang WJ, Lin GB, Zeng L. Protective effect of selenium-polysaccharides from the mycelia of Coprinus comatus on alloxan-induced oxidative stress in mice. Food Chem 2000;117:42-7.
22. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-54.
23. Benzie IFF, Strain JJ. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 1999;299:15-27.
24. Manna P, Sinha M, Sil PC. Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 2009;257:53-63.
25. Aebi H. Catalase in vitro. In: Packer L, ed. Methods in Enzymology. Vol. 105. New York: Academic Press, 1984:121-6.
26. Fridovich I. Superoxide dismutase: an adaptation to a paramagnetic gas. J Biol Chem 1989;264:7761-4.
27. Ellman GL. Tissue sulfhydryl group. Arch Biochem Biophys 1959;82:70-7.
28. Ohakawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95: 351-8.
29. Forscher BK, Paulsen AG, Hess WC. The pH of the periodontal pocket and the glycogen content of the adjacent tissue. J Dent Res 1954;33:444-9.
30. Andrew C, Cornish-Bowden S, Cornish-Bowden A. The kinetics of coupled enzyme reactions-application of the assay of glucose 6 phosphate dehydrogenase as coupling of enzyme. J Biochem 1974;141:205-9.
31. Rodriguez WE, Sen U, Tyagi N, Kumar M, Carneal G, Aggrawal D, Newsome J, Tyagi SC. PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice. Int J Biol Sci 2008;4:236-44.
32. Bhattacharyya SS, Paul S, Mandal SK, Banerjee A, Boujedaini N, Khuda-Bukhsh AR. A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice. Eur J Pharmacol 2009;614:128-36.
33. Chowdhury R, Dutta A, Chaudhuri SR, Sharma N, Giri AK, Chaudhuri K. In vitro and in vivo reduction of sodium arsenite induced toxicity by aqueous garlic extract. Food Chem Toxicol 2008;46:740-51.
34. Szkudelski T. The mechanism of alloxan and streptozocin action in b-cell of the rat pancreas. Physiol Res 2001;50:536-46.
35. González E, Jawerbaum A, Sinner D, Pustovrh White V, Capobianco E, Xaus C, Peralta C, Roselló-Catafau J. Streptozotocin pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. Nitric Oxide 2002;6:214-20.
36. Hamden K, Boujbiha MA, Masmoudi H, Ayadi FM, Jamoussi K, Elfeki A. Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomed Pharmacother 2009;63:95-9.
37. Cemek M, Kaǧa S, Simşek N, Büyükokuroǧlu ME, Konuk M. Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats. Nat Med 2008;62:284-93.
38. Singh AB, Akanksha, Singh N, Maurya R, Srivastava AK. Anti-hyperglycemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice. Int J Med Med Sci 2009;1:536-44.
39. Ellger B, Langouche L, Richir M, Debaveye Y, Vanhorebeek I, Paul A, Leeuwen V, Berghe GV. Modulation of regional nitric oxide metabolism: blood glucose control or insulin? Intensive Care Med 2008;34:1525-33.
40. Song MY, Kim EK, Moon WS, Park JW, Kim HJ, So HS, Park R, Kwon KB, Park BH. Sulforaphane protects against cytokine-and streptozotocin-induced b-cell damage by suppressing the NF-kB pathway. Toxicol Appl Pharmacol 2009;235:57-67.
41. Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet b-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 1998;55:1139-49.
42. Zhang HN, He JH, Yuan L, Lin ZB. In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage. Life Sci 2003;73:2307-19.
43. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol 1994;10:405-55.
44. Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits b cell function by inducing b cell expression of inducible nitric oxide synthase. J Exp Med 1995;181:559-68.
45. Simon HU, Yehia AH, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000;5:415-8.
46. Soriano FG, Virag L, Jagtap P, Szabo E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KGK, Salman A, Southan GJ, Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose)polymerase activation. Nature 2001;7:108-13.
47. Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Sting L, Wagner EF, Kolb H. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic b-cell destruction and diabetes development induced by streptozocin. Nat Med 1999;5:314-9.
48. Pieper AA, Brat DJ, Krung DK, Waitkins CC, Gupta A, Blackshaw S, Verma A, Wang ZQ, Snyder SH. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci 1997;96:3059-64.
49. Gabbay KH. Glycosylated haemoglobin and diabetic control. New Engl J Med 1976;295:443-44.
50. Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T. Glucokinase and IRS-2 are required for compensatory b cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest 2007;117:246-57.
51. Prasannan KG, Subrahmanyam K. Effects of insulin on the glycogen synthesis in vivo in the brain and liver of rats under different conditions. Ind J Med Res 1965;53:1003
52. Grover JK, Vats V, Rathi SS. Antihyperglycemic effects of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70