Anticancer potentials of root extract of Polygala senega against benzo[a]pyrene-induced lung cancer in mice

Journal of Chinese Integrative Medicine

Volumn 9, Issue 3, 2011, Pages 320-327

  Paul, Saili ^a   Bhattacharyya, Soumya Sundar ^a   Samaddar, Asmita ^a   Boujedaini, Naoual ^b   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

Antineoplastic agents, phytogenic; Benzo a pyrene; Lung neoplasms; Mice; Polygala

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALCOHOL; BENZO[A]PYRENE; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; OLIVE OIL; PLANT EXTRACT; POLYGALA SENEGA EXTRACT; SUPEROXIDE DISMUTASE; THIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; LIPID PEROXIDATION; LUNG CANCER; LUNG WEIGHT; MOUSE; NONHUMAN; POLYGALA SENEGA; POLYGALACEAE;

ADENOCARCINOMA; ANIMALS; BENZO(A)PYRENE; DRUGS, CHINESE HERBAL; LUNG NEOPLASMS; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; POLYGALA;

EID: 79952945946     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20110314     Document Type: Article

References (26)

1. Notani PN. Global variation in cancer incidence and mortality. Curr Sci. 2001; 81(5): 465-474. (Pubitemid 33616365)
2. Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer, 2003; 3(10): 733-711.
3. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P, Tobacco smoke carcinogens, DNA damage find p53 mutations in smoking-associated cancers. Oncogene 2002; 21(48): 7435-7451.
4. Boericke W. Pocket manual of homeopathic materia medica. Calcutta: Sett Dey and Co. 1976.
5. Paul S, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR. Anticancer potentials of root extract of Polygala senega and its PLGA nanoparticles- encapsulated form. Evid Based Complement Alternat Med. 2011; Epub 2010 Sep 21.
6. Paul S, Mandal SK, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR. In vitro and in vivo studies demonstrate anticancer property of root extract of Polygala senega. J Acupunct Meridian Stud. 2010; 3(3): 188-196.
7. Selvendiran K, Prince Vijeya Singh J, Sakthisekaran D. In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a) pyrene induced lung carcinogenesis in Swiss albino mice. Pulm Pharmacol Ther. 2006; 19 (2): 107-111.
8. Lim YY, Quah EPL. Antioxidant properties of different cultivars of Portulaca oleracea. Food Chem. 2007; 103 (3): 734-740.
9. Khuda Bukhsh AR, Bhattacharyya SS, Paul S, Dutta S, Boujedaini N, Belon P. Modulation of signal proteins: a plausible mechanism to explain how a potentized drug secale cor 30C diluted beyond Avogadro's limit combats skin papilloma in mice. Evid Based Complement Alternat Med. 2009 Jul 16. [Epub ahead of print]
10. Dhawan D, Balasubramanian S, Amonkar AJ, Singh N. Chemopreventive effect of 4′-demethyl epipodophyl-lotoxin on DMBA/TPA-induced mouse skin carcinogenesis. Carcinogenesis. 1999; 20(6): 997-1003. (Pubitemid 29263742)
11. Bhattacharyya SS, Paul S, Mandal SK, Banerjee A, Boujedaini N, Khuda-Bukhsh AR. A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice. Eur J Pharmacol. 2009; 614(1-3): 128-136.
12. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1): 265-275.
13. Buege JA, Aust SD, Microsomal lipid peroxidation. Methods Enzymol. 1978; 52: 302-310.
14. Maehly AC, Chance B. The assay of catalases and peroxidases. Methods Biochem Anal. 1954; 1: 357-424.
15. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys. 1984; 1(2): 130-132. (Pubitemid 15207169)
16. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1): 158-169.
17. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol, 1985; 113: 484-490. (Pubitemid 16195819)
18. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968; 25(1): 192-205.
19. Tessitore L, Costelli P, Baccino MF. Pharmacological interference with tissue hypercatabolism in tumour-bearing rats. Biochem J. 1994; 299(Pt 1): 71-78. (Pubitemid 24106290)
20. Hirano T, Franzén B, Kato H, Ebihara Y, Auer G. Genesis of squamous cell lung carcinoma. Sequential changes of proliferation. DNA ploidy, and p53 expression. Am J Pathol. 1904; 144(2): 296-302.
21. Kim KB, Lee BM. Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo (a) pyrene. Cancer Lett. 1997; 113(1-2): 205-212. (Pubitemid 27113250)
22. Oleinick NL, Chiu SM, Ramakrishnan N, Xue LY. The formation, identification, and significance of DNA-protein cross-links in mammalian cells. Br J Cancer Suppl. 1987; 8: 135-140.
23. Costa M. Analysis of DNA-protein complexes induced by chemical carcinogens. J Cell Biochem. 1990; 44(3): 127-135.
24. Kim HS, Kwack SJ, Lee BM. Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chem Biol Interact. 2000; 127(2): 139-150. (Pubitemid 30599479)
25. Ozen T, Korkmaz H. Modulatory effect of Urtica dioica L. (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice. Phytomedicine. 2003; 10(5): 405-415.
26. Moser HW, Moser AB, Peroxisomal disorders: overview. Ann N Y Acad Sci. 1996; 304: 427-441. (Pubitemid 27056628)