Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: Signaling cascade and drug-DNA interaction

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 110-121

  Bishayee, Kausik ^a   Chakraborty, Debrup ^a   Ghosh, Samrat ^a   Boujedaini, Naoual ^b   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

5 Lipoxygenase; 5 Oxo ETE receptor1; Apoptosis; Drug DNA interaction; Lycopodine; Mitochondrial membrane potential

Indexed keywords

ANDROGEN; ANTINEOPLASTIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; CASPASE 3; CYTOCHROME C; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; LYCOPODINE; LYCOPODIUM CLAVATUM EXTRACT; MEMBRANE PROTEIN; OXE RECEPTOR 1; PHOSPHATIDYLSERINE; PLANT EXTRACT; PROTEIN P53; UNCLASSIFIED DRUG;

5 LIPOXYGENASE GENE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CASPASE 3 GENE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYCOPODIUM; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOSS SPORE; OXE RECEPTOR 1 GENE; PRIORITY JOURNAL; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ALKALOIDS; ANDROGENS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; CATTLE; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DNA FRAGMENTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NUCLEIC ACID CONFORMATION; PROSTATIC NEOPLASMS; QUINOLIZINES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84871924397     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.10.041     Document Type: Article

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