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Volumn 313, Issue 18, 2007, Pages 3868-3880

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

Author keywords

Apoptosis; DLC1; Morphology; NSCLC; Protein nuclear translocation

Indexed keywords

ACTIN; CASPASE 3; DLC1 PROTEIN; SERINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 35248890380     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.08.009     Document Type: Article
Times cited : (40)

References (37)
  • 1
    • 0032524031 scopus 로고    scopus 로고
    • Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC1) homologous to rat RhoGAP
    • Yuan B.Z., Miller M.J., Keck C.L., Zimonjic D.B., Thorgeirsson S.S., and Popescu N.C. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC1) homologous to rat RhoGAP. Cancer Res. 58 (1998) 2196-2199
    • (1998) Cancer Res. , vol.58 , pp. 2196-2199
    • Yuan, B.Z.1    Miller, M.J.2    Keck, C.L.3    Zimonjic, D.B.4    Thorgeirsson, S.S.5    Popescu, N.C.6
  • 3
    • 0037438985 scopus 로고    scopus 로고
    • Promoter hypermethylation of DLC1, a candidate tumor suppressor gene, in several common human cancers
    • Yuan B.Z., Durkin M.E., and Popescu N.C. Promoter hypermethylation of DLC1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet. Cytogenet. 140 (2003) 113-117
    • (2003) Cancer Genet. Cytogenet. , vol.140 , pp. 113-117
    • Yuan, B.Z.1    Durkin, M.E.2    Popescu, N.C.3
  • 5
    • 0038001053 scopus 로고    scopus 로고
    • Transcriptional silencing of the DLC1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells
    • Kim T.Y., Jong H.S., Song S.H., Dimtchev A., Jeong S.J., Lee J.W., Kim N.K., Jung M., and Bang Y.J. Transcriptional silencing of the DLC1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene 22 (2003) 3943-3951
    • (2003) Oncogene , vol.22 , pp. 3943-3951
    • Kim, T.Y.1    Jong, H.S.2    Song, S.H.3    Dimtchev, A.4    Jeong, S.J.5    Lee, J.W.6    Kim, N.K.7    Jung, M.8    Bang, Y.J.9
  • 8
    • 33645058409 scopus 로고    scopus 로고
    • Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications
    • Guan M., Zhou X., Soulitzis N., Spandidos D.A., and Popescu N.C. Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Clin. Cancer Res. 12 (2006) 1412-1419
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1412-1419
    • Guan, M.1    Zhou, X.2    Soulitzis, N.3    Spandidos, D.A.4    Popescu, N.C.5
  • 11
    • 0034548009 scopus 로고    scopus 로고
    • DLC1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC1
    • Ng I.O., Liang Z.D., Cao L., and Lee T.K. DLC1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC1. Cancer Res. 60 (2000) 6581-6584
    • (2000) Cancer Res. , vol.60 , pp. 6581-6584
    • Ng, I.O.1    Liang, Z.D.2    Cao, L.3    Lee, T.K.4
  • 12
    • 25444499134 scopus 로고    scopus 로고
    • Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma
    • Wong C.M., Yam J.W., Ching Y.P., Yau T.O., Leung T.H., Jin D.Y., and Ng I.O. Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res. 65 (2005) 8861-8868
    • (2005) Cancer Res. , vol.65 , pp. 8861-8868
    • Wong, C.M.1    Yam, J.W.2    Ching, Y.P.3    Yau, T.O.4    Leung, T.H.5    Jin, D.Y.6    Ng, I.O.7
  • 13
    • 1442278561 scopus 로고    scopus 로고
    • Restoration of DLC1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells
    • Zhou X., Thorgeirsson S.S., and Popescu N.C. Restoration of DLC1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene 23 (2004) 1308-1313
    • (2004) Oncogene , vol.23 , pp. 1308-1313
    • Zhou, X.1    Thorgeirsson, S.S.2    Popescu, N.C.3
  • 14
    • 22244443056 scopus 로고    scopus 로고
    • The RhoGAP protein DLC1 functions as a metastasis suppressor in breast cancer cells
    • Goodison S., Yuan J., Sloan D., Kim R., Li C., Popescu N.C., and Urquidi V. The RhoGAP protein DLC1 functions as a metastasis suppressor in breast cancer cells. Cancer Res. 65 (2005) 6042-6053
    • (2005) Cancer Res. , vol.65 , pp. 6042-6053
    • Goodison, S.1    Yuan, J.2    Sloan, D.3    Kim, R.4    Li, C.5    Popescu, N.C.6    Urquidi, V.7
  • 15
    • 0035925082 scopus 로고    scopus 로고
    • Recent trends in lung cancer mortality in the United States
    • Jemal A., Chu K.C., and Tarone R.E. Recent trends in lung cancer mortality in the United States. J. Natl. Cancer Inst. 93 (2001) 277-283
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 277-283
    • Jemal, A.1    Chu, K.C.2    Tarone, R.E.3
  • 17
    • 34347333532 scopus 로고    scopus 로고
    • Expression profile of the tumor suppressor genes DLC1 and DLC-2 in solid tumors
    • Ullmannova V., and Popescu N.C. Expression profile of the tumor suppressor genes DLC1 and DLC-2 in solid tumors. Int. J. Oncol. 29 (2006) 1127-1132
    • (2006) Int. J. Oncol. , vol.29 , pp. 1127-1132
    • Ullmannova, V.1    Popescu, N.C.2
  • 18
    • 13844257513 scopus 로고    scopus 로고
    • DLC1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
    • Durkin M.E., Avner M.R., Huh C.G., Yuan B.Z., Thorgeirsson S.S., and Popescu N.C. DLC1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett. 579 (2005) 1191-1196
    • (2005) FEBS Lett. , vol.579 , pp. 1191-1196
    • Durkin, M.E.1    Avner, M.R.2    Huh, C.G.3    Yuan, B.Z.4    Thorgeirsson, S.S.5    Popescu, N.C.6
  • 19
    • 0028853289 scopus 로고
    • A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities
    • Homma Y., and Emori Y. A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. EMBO J. 14 (1995) 286-291
    • (1995) EMBO J. , vol.14 , pp. 286-291
    • Homma, Y.1    Emori, Y.2
  • 20
    • 0037139607 scopus 로고    scopus 로고
    • The role of Rho GTPases in disease development
    • Boettner B., and Van Aelst L. The role of Rho GTPases in disease development. Gene 286 (2002) 155-174
    • (2002) Gene , vol.286 , pp. 155-174
    • Boettner, B.1    Van Aelst, L.2
  • 21
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 22
    • 0035003212 scopus 로고    scopus 로고
    • Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
    • Price L.S., and Collard J.G. Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin. Cancer Biol. 11 (2001) 167-173
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 167-173
    • Price, L.S.1    Collard, J.G.2
  • 23
    • 0035964458 scopus 로고    scopus 로고
    • Ras and Rho regulation of the cell cycle and oncogenesis
    • Pruitt K., and Der C.J. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett. 171 (2001) 1-10
    • (2001) Cancer Lett. , vol.171 , pp. 1-10
    • Pruitt, K.1    Der, C.J.2
  • 24
    • 0035575585 scopus 로고    scopus 로고
    • Rho family proteins: coordinating cell responses
    • Ridley A.J. Rho family proteins: coordinating cell responses. Trends Cell Biol. 11 (2001) 471-477
    • (2001) Trends Cell Biol. , vol.11 , pp. 471-477
    • Ridley, A.J.1
  • 26
    • 0345059753 scopus 로고    scopus 로고
    • The 14-3-3 cancer connection
    • Hermeking H. The 14-3-3 cancer connection. Nat. Rev., Cancer 3 (2003) 931-943
    • (2003) Nat. Rev., Cancer , vol.3 , pp. 931-943
    • Hermeking, H.1
  • 27
    • 35248838504 scopus 로고    scopus 로고
    • DLC1 exerts its suppressive effect through the specific inhibition of Cdc42-mediated cell growth promotion in human NCI-H358 lung adenocarcinoma cell line
    • Yuan B.Z., Jefferson A.M., and Reynolds S.H. DLC1 exerts its suppressive effect through the specific inhibition of Cdc42-mediated cell growth promotion in human NCI-H358 lung adenocarcinoma cell line. 95th AACR Annual Meeting, Orlando, Florida (2004)
    • (2004) 95th AACR Annual Meeting, Orlando, Florida
    • Yuan, B.Z.1    Jefferson, A.M.2    Reynolds, S.H.3
  • 28
    • 0033942431 scopus 로고    scopus 로고
    • The morphology of apoptosis
    • Hacker G. The morphology of apoptosis. Cell Tissue Res. 301 (2000) 5-17
    • (2000) Cell Tissue Res. , vol.301 , pp. 5-17
    • Hacker, G.1
  • 29
    • 0033581010 scopus 로고    scopus 로고
    • Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho
    • Sekimata M., Kabuyama Y., Emori Y., and Homma Y. Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho. J. Biol. Chem. 274 (1999) 17757-17762
    • (1999) J. Biol. Chem. , vol.274 , pp. 17757-17762
    • Sekimata, M.1    Kabuyama, Y.2    Emori, Y.3    Homma, Y.4
  • 30
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Gorlich D., and Mattaj I.W. Nucleocytoplasmic transport. Science 271 (1996) 1513-1518
    • (1996) Science , vol.271 , pp. 1513-1518
    • Gorlich, D.1    Mattaj, I.W.2
  • 32
    • 0034714438 scopus 로고    scopus 로고
    • Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis
    • Yamazaki Y., Tsuruga M., Zhou D., Fujita Y., Shang X., Dang Y., Kawasaki K., and Oka S. Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. Exp. Cell Res. 259 (2000) 64-78
    • (2000) Exp. Cell Res. , vol.259 , pp. 64-78
    • Yamazaki, Y.1    Tsuruga, M.2    Zhou, D.3    Fujita, Y.4    Shang, X.5    Dang, Y.6    Kawasaki, K.7    Oka, S.8
  • 33
  • 34
    • 16844376789 scopus 로고    scopus 로고
    • Caspase regulation in non-small cell lung cancer and its potential for therapeutic exploitation
    • Fennell D.A. Caspase regulation in non-small cell lung cancer and its potential for therapeutic exploitation. Clin. Cancer Res. 11 (2005) 2097-2105
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2097-2105
    • Fennell, D.A.1
  • 35
    • 25444432871 scopus 로고    scopus 로고
    • Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport
    • Minakhina S., Myers R., Druzhinina M., and Steward R. Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport. BMC Cell Biol. 6 (2005) 1-11
    • (2005) BMC Cell Biol. , vol.6 , pp. 1-11
    • Minakhina, S.1    Myers, R.2    Druzhinina, M.3    Steward, R.4
  • 36
    • 33646185479 scopus 로고    scopus 로고
    • Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells
    • Hers I., Wherlock M., Homma Y., Yagisawa H., and Tavare J.M. Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. J. Biol. Chem. 281 (2006) 4762-4770
    • (2006) J. Biol. Chem. , vol.281 , pp. 4762-4770
    • Hers, I.1    Wherlock, M.2    Homma, Y.3    Yagisawa, H.4    Tavare, J.M.5


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