Cytokine Spätzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 51, 2013, Pages 20461-20466

  Lewis, Miranda ^a   Arnot, Christopher J ^a   Beeston, Helen ^b   McCoy, Airlie ^c   Ashcroft, Alison E ^b   Gay, Nicholas J ^a   Gangloff, Monique ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Crystallography; Isothermal titration calorimetry; Mass spectrometry; Spz ligand; Toll receptor

Indexed keywords

CYSTINE; CYTOKINE; GLYCAN; LEUCINE; MEMBRANE PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; NEUROTROPHIN RECEPTOR P75; SPZ PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; ENDOTOXIN; NERVE GROWTH FACTOR RECEPTOR; PROTEIN BINDING; SPATZLE PROTEIN, DROSOPHILA; TL PROTEIN, DROSOPHILA;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; DROSOPHILA; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DROSOPHILA MELANOGASTER; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY; CRYSTALLOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; PROTEIN BINDING; SPZ LIGAND; TOLL RECEPTOR;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOTOXINS; IMMUNITY, INNATE; NERVE GROWTH FACTOR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECEPTOR, NERVE GROWTH FACTOR; REPETITIVE SEQUENCES, AMINO ACID; TOLL-LIKE RECEPTORS;

CRYSTALLOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; SPZ LIGAND; TOLL RECEPTOR;

EID: 84890847576     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317002110     Document Type: Article

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