Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor

Structure

Volumn 21, Issue 1, 2013, Pages 143-153

  Gangloff, Monique ^a   Arnot, Christopher J ^a   Lewis, Miranda ^a   Gay, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; TOLL LIKE RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DROSOPHILA; GENE DELETION; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA;

EID: 84872153469     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.11.003     Document Type: Article

References (40)

1. K.V. Anderson, L. Bokla, and C. Nüsslein-Volhard Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product Cell 42 1985 791 798 (Pubitemid 16083720)
2. C.J. Arnot, N.J. Gay, and M. Gangloff Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor J. Biol. Chem. 285 2010 19502 19509
3. J.P. Aurikko, B.T. Ruotolo, J.G. Grossmann, M.C. Moncrieffe, E. Stephens, V.M. Leppänen, C.V. Robinson, M. Saarma, R.A. Bradshaw, and T.L. Blundell Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR J. Biol. Chem. 280 2005 33453 33460 (Pubitemid 41397144)
4. W.A. Barton, B.P. Liu, D. Tzvetkova, P.D. Jeffrey, A.E. Fournier, D. Sah, R. Cate, S.M. Strittmatter, and D.B. Nikolov Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins EMBO J. 22 2003 3291 3302 (Pubitemid 36834859)
5. T. Beck, A. Krasauskas, T. Gruene, and G.M. Sheldrick A magic triangle for experimental phasing of macromolecules Acta Crystallogr. D Biol. Crystallogr. 64 2008 1179 1182
6. H. Bilak, S. Tauszig-Delamasure, and J.L. Imler Toll and Toll-like receptors in Drosophila Biochem. Soc. Trans. 31 2003 648 651 (Pubitemid 36750748)
7. E. Blanc, P. Roversi, C. Vonrhein, C. Flensburg, S.M. Lea, and G. Bricogne Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT Acta Crystallogr. D Biol. Crystallogr. 60 2004 2210 2221 (Pubitemid 41742773)
8. V.B. Chen, W.B. Arendall 3rd, J.J. Headd, D.A. Keedy, R.M. Immormino, G.J. Kapral, L.W. Murray, J.S. Richardson, and D.C. Richardson MolProbity: all-atom structure validation for macromolecular crystallography Acta Crystallogr. D Biol. Crystallogr. 66 2010 12 21
9. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132 (Pubitemid 41742764)
10. M. Gangloff, A.N. Weber, R.J. Gibbard, and N.J. Gay Evolutionary relationships, but functional differences, between the Drosophila and human Toll-like receptor families Biochem. Soc. Trans. 31 2003 659 663 (Pubitemid 36750751)
11. M. Gangloff, A. Murali, J. Xiong, C.J. Arnot, A.N. Weber, A.M. Sandercock, C.V. Robinson, R. Sarisky, A. Holzenburg, C. Kao, and N.J. Gay Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle J. Biol. Chem. 283 2008 14629 14635
12. N.J. Gay, and F.J. Keith Drosophila Toll and IL-1 receptor Nature 351 1991 355 356
13. N.J. Gay, and M. Gangloff Structure and function of Toll receptors and their ligands Annu. Rev. Biochem. 76 2007 141 165
14. P. Georgel, Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M.B. Oldstone, and B. Beutler Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway Virology 362 2007 304 313 (Pubitemid 46678142)
15. X.L. He, and K.C. Garcia Structure of nerve growth factor complexed with the shared neurotrophin receptor p75 Science 304 2004 870 875 (Pubitemid 38620186)
16. X.L. He, J.F. Bazan, G. McDermott, J.B. Park, K. Wang, M. Tessier-Lavigne, Z. He, and K.C. Garcia Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition Neuron 38 2003 177 185 (Pubitemid 36555645)
17. A. Hoffmann, A. Funkner, P. Neumann, S. Juhnke, M. Walther, A. Schierhorn, U. Weininger, J. Balbach, G. Reuter, and M.T. Stubbs Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms J. Biol. Chem. 283 2008 32598 32609
18. L. Holm, and P. Rosenström Dali server: conservation mapping in 3D Nucleic Acids Res. 38 Web Server issue 2010 W545 W549
19. E.G. Huizinga, S. Tsuji, R.A. Romijn, M.E. Schiphorst, P.G. de Groot, J.J. Sixma, and P. Gros Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain Science 297 2002 1176 1179 (Pubitemid 36196734)
20. M.S. Jin, S.E. Kim, J.Y. Heo, M.E. Lee, H.M. Kim, S.G. Paik, H. Lee, and J.O. Lee Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide Cell 130 2007 1071 1082 (Pubitemid 47410281)
21. W. Kabsch Xds Acta Crystallogr. D Biol. Crystallogr. 66 2010 125 132
22. R.B. Kapust, J. Tözsér, J.D. Fox, D.E. Anderson, S. Cherry, T.D. Copeland, and D.S. Waugh Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency Protein Eng. 14 2001 993 1000 (Pubitemid 34137240)
23. H.M. Kim, B.S. Park, J.I. Kim, S.E. Kim, J. Lee, S.C. Oh, P. Enkhbayar, N. Matsushima, H. Lee, O.J. Yoo, and J.O. Lee Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran Cell 130 2007 906 917 (Pubitemid 47332573)
24. J.I. Kim, C.J. Lee, M.S. Jin, C.H. Lee, S.G. Paik, H. Lee, and J.O. Lee Crystal structure of CD14 and its implications for lipopolysaccharide signaling J. Biol. Chem. 280 2005 11347 11351 (Pubitemid 40418442)
25. T.M. Laue, B.D. Shah, T.M. Ridgeway, and S.L. Pelletier Computer-aided interpretation of analytical sedimentation data for proteins A.J.R.S.E. Harding, J.C. Horton, Analytical Ultracentrifugation in Biochemistry and Polymer Science 1992 The Royal Society of Chemistry Cambridge, U.K. 90 125
26. B. Lemaitre, E. Nicolas, L. Michaut, J.M. Reichhart, and J.A. Hoffmann The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 1996 973 983 (Pubitemid 26336801)
27. E.K. LeMosy, Y.Q. Tan, and C. Hashimoto Activation of a protease cascade involved in patterning the Drosophila embryo Proc. Natl. Acad. Sci. USA 98 2001 5055 5060 (Pubitemid 32397081)
28. R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397 (Pubitemid 27334820)
29. K. Mizuguchi, J.S. Parker, T.L. Blundell, and N.J. Gay Getting knotted: a model for the structure and activation of Spätzle Trends Biochem. Sci. 23 1998 239 242 (Pubitemid 28343364)
30. M. Nakamoto, R.H. Moy, J. Xu, S. Bambina, A. Yasunaga, S.S. Shelly, B. Gold, and S. Cherry Virus recognition by Toll-7 activates antiviral autophagy in Drosophila Immunity 36 2012 658 667
31. C. Nishitani, H. Mitsuzawa, H. Sano, T. Shimizu, N. Matsushima, and Y. Kuroki Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40 J. Biol. Chem. 281 2006 38322 38329 (Pubitemid 46041955)
32. B.S. Park, D.H. Song, H.M. Kim, B.S. Choi, H. Lee, and J.O. Lee The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex Nature 458 2009 1191 1195
33. D.S. Schneider, K.L. Hudson, T.Y. Lin, and K.V. Anderson Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo Genes Dev. 5 1991 797 807 (Pubitemid 21905997)
34. P. Schuck Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling Biophys. J. 78 2000 1606 1619 (Pubitemid 30141584)
35. D. Spillmann Carbohydrates in cellular recognition: from leucine-zipper to sugar-zipper? Glycoconj. J. 11 1994 169 171 (Pubitemid 24300496)
36. N. Tomiya, S. Narang, Y.C. Lee, and M.J. Betenbaugh Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines Glycoconj. J. 21 2004 343 360 (Pubitemid 39434562)
37. S. Uff, J.M. Clemetson, T. Harrison, K.J. Clemetson, and J. Emsley Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation J. Biol. Chem. 277 2002 35657 35663
38. A.N. Weber, S. Tauszig-Delamasure, J.A. Hoffmann, E. Lelièvre, H. Gascan, K.P. Ray, M.A. Morse, J.L. Imler, and N.J. Gay Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Nat. Immunol. 4 2003 794 800 (Pubitemid 36986764)
39. A.N. Weber, M.C. Moncrieffe, M. Gangloff, J.L. Imler, and N.J. Gay Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway J. Biol. Chem. 280 2005 22793 22799 (Pubitemid 40853185)
40. S.I. Yoon, O. Kurnasov, V. Natarajan, M. Hong, A.V. Gudkov, A.L. Osterman, and I.A. Wilson Structural basis of TLR5-flagellin recognition and signaling Science 335 2012 859 864