Structural insight into the mechanism of activation of the toll receptor by the dimeric ligand Spätzle

Journal of Biological Chemistry

Volumn 283, Issue 21, 2008, Pages 14629-14635

  Gangloff, Monique ^a   Murali, Ayaluru ^b   Xiong, Jin ^b   Arnot, Christopher J ^a   Weber, Alexander N ^a,f   Sandercock, Alan M ^d   Robinson, Carol V ^d   Sarisky, Robert ^e   Holzenburg, Andreas ^c   Kao, Cheng ^b   Gay, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TEXAS A AND M UNIVERSITY   (United States)

^c Texas AandM University   (United States)

^d Centocor Research and Development Inc ^*  (United Kingdom)

^e CENTOCOR INC   (United States)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING ENERGY; BINDING SITES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGANDS; MASS SPECTROMETRY; PORT TERMINALS; THEOREM PROVING;

ACTIVATED COMPLEXES; ALLOSTERIC MECHANISMS; APO FORMS; BINDING MODES; CONFORMATIONAL CHANGES; CYTOKINE; DIMERIC LIGANDS; ECTODOMAIN; EMBRYONIC PATTERNING; INNATE IMMUNITIES; JUXTAMEMBRANE; N TERMINUSES; STRUCTURAL INSIGHTS;

BIOACTIVITY;

CYTOKINE; PROTEIN SPATZLE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; LIGAND; SPATZLE PROTEIN, DROSOPHILA; TOLL PROTEIN, DROSOPHILA;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; ARMYWORM; CELL LINE; CHEMISTRY; CRYOELECTRON MICROSCOPY; DIMERIZATION; DROSOPHILA MELANOGASTER; METABOLISM; ULTRASTRUCTURE;

FUNGI; POSIBACTERIA; SOLENOIDEA;

ANIMALS; CELL LINE; CRYOELECTRON MICROSCOPY; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; LIGANDS; PROTEIN BINDING; SPODOPTERA; TOLL-LIKE RECEPTORS;

EID: 47249114405     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800112200     Document Type: Article

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