Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

Science

Volumn 304, Issue 5672, 2004, Pages 870-875

  He, Xiao Lin ^a   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; CONFORMATIONS; DIMERS; ENZYME KINETICS; GROWTH KINETICS;

CELL SURFACE RECEPTORS; NERVE GROWTH FACTORS;

NEUROLOGY;

NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75;

BIOLOGY;

ALLOSTERISM; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALORIMETRY; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DIMERIZATION; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; LASERS; LIGANDS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NERVE GROWTH FACTOR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINANT PROTEINS; SCATTERING, RADIATION; SIGNAL TRANSDUCTION; THERMODYNAMICS;

VERTEBRATA;

EID: 2442434770     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1095190     Document Type: Article

References (25)

1. H. Bothwell, Annu. Rev. Neurosci. 18, 223 (1995).
2. M. Bibel, Y. A. Barde, Genes Dev. 14, 2919 (2000).
3. G. R. Lewin, Y. A. Barde, Annu. Rev. Neurosci. 19, 289 (1996).
4. C. F. Ibanez, Trends Biotechnol. 13, 217 (1995).
5. M. V. Chao, Nature Rev. Neurosci. 4, 299 (2003).
6. G. Dechant, Y. A. Barde. Nature Neurosci. 5, 1131 (2002).
7. B. L. Hempstead, Curr. Opin. Neurobiol. 12, 260 (2002).
8. E. J. Huang, L. F. Reichardt. Annu. Rev. Biochem. 72, 609 (2003).
9. S. Rabizadeh, D. E. Bredesen, Cytokine Growth Factor Rev. 14, 225 (2003).
10. B. L. Hempstead, D. Martin-Zanca, D. R. Kaplan, L. F. Parada, M. V. Chao, Nature 350, 678 (1991).
11. C. Wiesmann, M. H. Ultsch, S. H. Bass, A. M. de Vos, Nature 401, 184 (1999).
12. Materials and methods are provided in Supporting Online Material (SOM).
13. P. M. Grob, A. H. Ross, H. Koprowski, M. Bothwell, J. Biol. Chem. 260, 8044 (1985).
14. S. Jing, P. Tapley, M. Barbacid, Neuron 9, 1067 (1992).
15. N. Q. McDonald et al., Nature 354, 411 (1991).
16. D. W. Banner et al., Cell 73, 431 (1993).
17. M. J. Boulanger, A. J. Bankovich, T. Kortemme, D. Baker, K. C. Garcia, Mol. Cell 12, 577 (2003).
18. A. Rodriguez-Tebar, G. Dechant, Y. A. Barde, Neuron 4, 487 (1990).
19. S. C. Garman, B. A. Wurzburg, S. S. Tarchevskaya, J. P. Kinet, T. S. Jardetzky, Nature 406, 259 (2000).
20. P. Li et al., Nature Immunol. 2, 443 (2001).
21. X. He, D. Chow, M. M. Martick, K. C. Garcia, Science 293, 1657 (2001).
22. J. J. Wang et al., J. Neurosci. Res. 60, 587 (2000).
23. T. Yamashita, K. L. Tucker, Y. A. Barde, Neuron 24, 585 (1999).
24. K. C. Wang, J. A. Kim, R. Sivasankaran, R. Segal, Z. He, Nature 420, 74 (2002).
25. We thank A. M. de Vos (Genentech, Inc.) for the gift of recombinant human NGF, NT-4/5 and NT-3; M. Boulanger for assistance with MALS; W. Mobley for helpful discussions and mouse NGF; and B. Hempstead and C. F. Ibanez for critically reading the manuscript. K.C.G. Is supported by the American Heart Association, Christopher Reeve Paralysis Foundation, Keck Foundation, and NIH. X.H Is supported by the Fritz Krauth Memorial Fellowship from Paralyzed Veterans of America, Spinal Cord Research Foundation. The coordinates and structural factors have been deposited in the Protein Data Bank with accession number 1SG1.