Role of the spätzle pro-domain in the generation of an active toll receptor ligand

Journal of Biological Chemistry

Volumn 282, Issue 18, 2007, Pages 13522-13531

  Weber, Alexander N R ^a,c   Gangloff, Monique ^a   Moncrieffe, Martin C ^a   Hyvert, Yann ^b   Imler, Jean Luc ^b   Gay, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYONIC PATTERNING; INNATE IMMUNITY; PROTEOLYTIC PROCESSING;

BINDING ENERGY; BIOSYNTHESIS; CELL CULTURE; CROSSLINKING; IMMUNIZATION; PROTEINS;

LIGANDS;

CYTOKINE; DROSOPHILA PROTEIN; LIGAND; SPATZLE PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; SPATZLE PROTEIN, DROSOPHILA;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; GENE FUNCTION; GENE MAPPING; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; DIMERIZATION; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SECRETION;

ANIMALS; CYTOKINES; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; LIGANDS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 34250314533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700068200     Document Type: Article

References (36)

1. Imler, J. L., and Hoffmann, J. A. (2001) Trends Cell Biol. 11, 304-311
2. Belvin, M. P., and Anderson, K. V. (1996) Annu. Rev. Cell Dev. Biol. 12, 393-416
3. Janeway, C. A., and Medzhitov, R. (2002) Annu. Rev. Immunol. 20, 197-216
4. Kirk, P., and Bazan, J. F. (2005) Immunity 23, 347-350
5. DeLotto, Y., and DeLotto, R. (1998) Mech. Dev. 72, 141-148
6. Bibel, M., and Barde, Y. A. (2000) Genes Dev. 14, 2919-2937
7. Mizuguchi, K., Parker, J. S., Blundell, T. L., and Gay, N. J. (1998) Trends Biochem. Sci. 23, 239-242
8. Weber, A., Tauszig-Delamasure, S., Hoffmann, J., Lelièvre, E., Gascan, H., Ray, K., Morse, M., Imler, J., and Gay, N. (2003) Nat. Immun. 4, 794-800
9. LeMosy, E. K., Tan, Y. Q., and Hashimoto, C. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5055-5060
10. Dissing, M., Giordano, H., and DeLotto, R. (2001)EMBO J. 20, 2387-2393
11. Rose, T., LeMosy, E. K., Cantwell, A. M., Banerjee-Roy, D., Skeath, J. B., and Di Cera, E. (2003) J. Biol. Chem. 278, 11320-11330
12. Chasan, R., Jin, Y., and Anderson, K. V. (1992) Development (Camb.) 115, 607-616
13. Jang, I. H., Chosa, N., Kim, S. H., Nam, H. J., Lemaitre, B., Ochiai, M., Kambris, Z., Brun, S., Hashimoto, C., Ashida, M., Brey, P. T., and Lee, W. J. (2006) Dev. Cell 10, 45-55
14. Weber, A. N., Moncrieffe, M. C., Gangloff, M., Imler, J. L., and Gay, N. J. (2005) J. Biol. Chem. 280, 22793-22799
15. DeLotto, Y., Smith, C., and DeLotto, R. (2001) Mol. Gen. Genet. 264, 643-652
16. Kapust, R. B., Tozser, J., Fox, J. D., Anderson, D. E., Cherry, S., Copeland, T. D., and Waugh, D. S. (2001) Protein Eng. 14, 993-1000
17. Tessier, D. C., Thomas, D. Y., Khouri, H. E., Laliberte, F., and Vernet, T. (1991) Gene (Amst.) 98, 177-183
18. Schneider, D. S., Jin, Y., Morisato, D., and Anderson, K. V. (1994) Development (Camb.) 120, 1243-1250
19. He, X. L., and Garcia, K. C. (2004) Science 304, 870-875
20. Carroll, S. B., Winslow, G. M., Twombly, V. J., and Scott, M. P. (1987) Development (Camb.) 99, 327-332
21. Parodi, A. J. (2000) Annu. Rev. Biochem. 69, 69-93
22. Dougherty, W. G., and Parks, T. D. (1989) Virology 172, 145-155
23. Morisato, D. (2001) Development (Camb.) 128, 2309-2319
24. Suter, U., Heymach, J. V., Jr., and Shooter, E. M. (1991) EMBO J. 10, 2395-2400
25. Rattenholl, A., Ruoppolo, M., Flagiello, A., Monti, M., Vinci, F., Marino, G., Lilie, H., Schwarz, E., and Rudolph, R. (2001) J. Mol. Biol. 305, 523-533
26. Morisato, D., and Anderson, K. V. (1994) Cell 76, 677-688
27. Moussian, B., and Roth, S. (2005) Curr. Biol. 15, R887-899
28. Chang, A. J., and Morisato, D. (2002) Development (Camb.) 129, 5635-5645
29. Gierer, A., and Meinhardt, H. (1972) Kybernetik 12, 30-39
30. McDonald, N. Q., and Hendrickson, W. A. (1993) Cell 73, 421-424
31. Lawrence, D. A. (2001) Mol. Cell. Biochem. 219, 163-170
32. Paoletti, F., Konarev, P. V., Covaceuszach, S., Schwarz, E., Cattaneo, A., Lamba, D., and Svergun, D. I. (2006) Biochem. Soc. Trans. 34, 605-606
33. Stroud, R. M., Kossiakoff, A. A., and Chambers, J. L. (1977) Annu. Rev. Biophys. Bioeng. 6, 177-193
34. Kliemannel, M., Golbik, R., Rainer, R., Schwarz, E., and Lilie, H. (2007) Protein Sci., in press
35. Taylor, W. R. (1997) J. Mol. Biol. 269, 902-943
36. Gay, N., Gangloff, M., and Weber, A. (2006) Nat. Rev. Immunol. 6, 693-698