A network of interorganellar communications underlies cellular aging

IUBMB Life

Volumn 65, Issue 8, 2013, Pages 665-674

  Leonov, Anna ^a   Titorenko, Vladimir I ^a  

^a Gina Cody School of Engineering and Computer Science   (Canada)

Author keywords

an endomembrane system governing cellular aging; biomolecular networks of cellular aging; cell autonomous mechanisms of organismal aging; cellular aging; interorganellar communications; lysosomes and vacuoles; mitochondria; peroxisomes; signaling network of cellular aging

Indexed keywords

AFO1 PROTEIN; CELL NUCLEUS DNA; DNA FRAGMENT; HISTONE H2B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; RIBOSOME PROTEIN; SIRTUIN 1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ADIPOGENESIS; AUTOPHAGY; CELL AGING; CELL COMMUNICATION; CELL DEATH; CELL ENERGY; CELL ORGANELLE; CELL SURVIVAL; CELL VACUOLE; CELLULAR STRESS RESPONSE; CITRIC ACID CYCLE; CYTOSOL; DNA REPAIR; DNA REPLICATION; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; FATTY ACID OXIDATION; GENOMIC INSTABILITY; INTRACELLULAR SPACE; LYSOSOME; MAMMAL CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEAR IMPORT; PEROXISOME; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS; RESPIRATORY CHAIN; REVIEW; TELOMERE HOMEOSTASIS; YEAST CELL;

EUKARYOTA;

EID: 84890800995     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1183     Document Type: Review

References (50)

1. Fontana, L., Partridge, L., and, Longo, V. D., (2010) Extending healthy life span-from yeast to humans. Science 328, 321-326.
2. Longo, V. D., Shadel, G. S., Kaeberlein, M., and, Kennedy, B., (2012) Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 16, 18-31.
3. Greer, E. L., and, Brunet, A., (2008) Signaling networks in aging. J. Cell Sci. 121, 407-412. (Pubitemid 351405048)
4. Goldberg, A. A., Bourque, S. D., Kyryakov, P., Gregg, C., Boukh-Viner, T., et al. (2009) Effect of calorie restriction on the metabolic history of chronologically aging yeast. Exp. Gerontol. 44, 555-571.
5. Burstein, M. T., Kyryakov, P., Beach, A., Richard, V. R., Koupaki, O., et al. (2012) Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle 11, 3443-3462.
6. Beach, A., Burstein, M. T., Richard, V. R., Leonov, A., Levy, S., et al. (2012) Integration of peroxisomes into an endomembrane system that governs cellular aging. Front. Physiol. 3, 283.
7. Jazwinski, S. M., (2012) The retrograde response and other pathways of interorganelle communication in yeast replicative aging. Subcell. Biochem. 57, 79-100.
8. Nunnari, J., and, Suomalainen, A., (2012) Mitochondria: in sickness and in health. Cell 148, 1145-1159.
9. Titorenko, V. I., and, Terlecky, S. R., (2011) Peroxisome metabolism and cellular aging. Traffic 12, 252-259.
10. Zoncu, R., Efeyan, A., and, Sabatini, D. M., (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35.
11. Laplante, M., and, Sabatini, D. M., (2012) mTOR signaling in growth control and disease. Cell 149, 274-293.
12. Jazwinski, S. M., and, Kriete, A., (2012) The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front. Physiol. 3, 139.
13. Pellegrino, M. W., Nargund, A. M., and, Haynes, C. M., (2013) Signaling the mitochondrial unfolded protein response. Biochim. Biophys. Acta 1833, 410-416.
14. Heeren, G., Rinnerthaler, M., Laun, P., von Seyerl, P., Kössler, S., et al. (2009) The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging 1, 622-636.
15. Baker, B. M., and, Haynes, C. M., (2011) Mitochondrial protein quality control during biogenesis and aging. Trends Biochem. Sci. 36, 254-261.
16. Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M., and, Haynes, C. M., (2012) Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337, 587-590.
17. Haynes, C. M., Yang, Y., Blais, S. P., Neubert, T. A., and, Ron, D., (2010) The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol. Cell 37, 529-540.
18. Butow, R. A., and, Avadhani, N. G., (2004) Mitochondrial signaling: the retrograde response. Mol. Cell 14, 1-15. (Pubitemid 38469905)
19. 2+ homeostasis in peripheral neurones: implications for changes in function. Aging Cell 6, 285-296. (Pubitemid 46785134)
20. + metabolism and SIRT1 activity. Nature 458, 1056-1060.
21. Libert, S., and, Guarente, L., (2013) Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu. Rev. Physiol. 75, 669-684.
22. Giorgio, M., Trinei, M., Migliaccio, E., and, Pelicci, P. G., (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat. Rev. Mol. Cell Biol. 8, 722-728. (Pubitemid 47312827)
23. Oh, S. W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R. J., et al. (2005) JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102, 4494-4499. (Pubitemid 40397140)
24. Wang, M. C., Bohmann, D., and, Jasper, H., (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125.
25. Lehtinen, M. K., Yuan, Z., Boag, P. R., Yang, Y., Villén, J., et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987-1001. (Pubitemid 43795191)
26. Harman, D., (1972) The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20, 145-147.
27. Vendelbo, M. H., and, Nair, K. S., (2011) Mitochondrial longevity pathways. Biochim. Biophys. Acta 1813, 634-644.
28. Xu, X. M., and, Møller, S. G., (2011) Iron-sulfur clusters: biogenesis, molecular mechanisms, and their functional significance. Antioxid. Redox Signal. 15, 271-307.
29. Gottschling, D. E., (2012) Molecular biology. Fragile delivery to the genome. Science 337, 160-161.
30. Veatch, J. R., McMurray, M. A., Nelson, Z. W., and, Gottschling, D. E., (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137, 1247-1258.
31. Cheng, X., and, Ivessa, A. S., (2010) The migration of mitochondrial DNA fragments to the nucleus affects the chronological aging process of Saccharomyces cerevisiae. Aging Cell 9, 919-923.
32. Cheng, X., and, Ivessa, A. S., (2012) Accumulation of linear mitochondrial DNA fragments in the nucleus shortens the chronological life span of yeast. Eur. J. Cell Biol. 91, 782-788.
33. Perocchi, F., Jensen, L. J., Gagneur, J., Ahting, U., von Mering, C., et al. (2006) Assessing systems properties of yeast mitochondria through an interaction map of the organelle. PLoS Genet. 2, e170.
34. Caballero, A., Ugidos, A., Liu, B., Öling, D., Kvint, K., et al. (2011) Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol. Cell 42, 390-400.
35. Kim, J., Kundu, M., Viollet, B., and, Guan, K. L., (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132-141.
36. Bungard, D., Fuerth, B. J., Zeng, P. Y., Faubert, B., Maas, N. L., et al. (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329, 1201-1205.
37. Narbonne, P., and, Roy, R., (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 457, 210-214.
38. Koppen, M., and, Langer, T., (2007) Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases. Crit. Rev. Biochem. Mol. Biol. 42, 221-242. (Pubitemid 46911963)
39. Delaney, J. R., Ahmed, U., Chou, A., Sim, S., Carr, D., et al. (2013) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12, 156-166.
40. Bhatia-Kiššová, I., and, Camougrand, N., (2010) Mitophagy in yeast: actors and physiological roles. FEMS Yeast Res. 10, 1023-1034.
41. Journo, D., Mor, A., and, Abeliovich, H., (2009) Aup1-mediated regulation of Rtg3 during mitophagy. J. Biol. Chem. 284, 35885-35895.
42. Piper, M. D., Partridge, L., Raubenheimer, D., and, Simpson, S. J., (2011) Dietary restriction and aging: a unifying perspective. Cell Metab. 14, 154-160.
43. Jewell, J. L., Russell, R. C., and, Guan, K. L., (2013) Amino acid signalling upstream of mTOR. Nat. Rev. Mol. Cell Biol. 14, 133-139.
44. Goldberg, A. A., Richard, V. R., Kyryakov, P., Bourque, S. D., Beach, A., et al. (2010) Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging 2, 393-414.
45. Hughes, A. L., and, Gottschling, D. E., (2012) An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492, 261-265.
46. Schmidt, M., and, Kennedy, B. K., (2012) Aging: one thing leads to another. Curr. Biol. 22, R1048-R1051.
47. Goldberg, A. A., Bourque, S. D., Kyryakov, P., Boukh-Viner, T., Gregg, C., et al. (2009) A novel function of lipid droplets in regulating longevity. Biochem. Soc. Trans. 37, 1050-1055.
48. Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11, 1305-1314.
49. Minois, N., Carmona-Gutierrez, D., and, Madeo, F., (2011) Polyamines in aging and disease. Aging 3, 716-732.
50. Seo, J. G., Lai, C. Y., Miceli, M. V., and, Jazwinski, S. M., (2007) A novel role of peroxin PEX6: suppression of aging defects in mitochondria. Aging Cell 6, 405-413. (Pubitemid 46785145)