A novel function of lipid droplets in regulating longevity

Biochemical Society Transactions

Volumn 37, Issue 5, 2009, Pages 1050-1055

  Goldberg, Alexander A ^a   Bourque, Simon D ^a   Kyryakov, Pavlo ^a   Boukh Viner, Tatiana ^a   Gregg, Christopher ^a   Beach, Adam ^a   Burstein, Michelle T ^a   Machkalyan, Gayane ^a   Richard, Vincent ^a   Rampersad, Sonia ^a   Titorenko, Vladimir I ^a  

^a Gina Cody School of Engineering and Computer Science   (Canada)

Author keywords

Aging; Anti aging drug; Lipid droplet; Longevity; Necrosis; Peroxisomedecay accelerating factor 16; DAG, diacylglycerol; ER, endoplasmic reticulum; LD, lipid droplet; NEFA, non esterified ('free') fatty acid; PKC, protein kinase C; SIRT1, sirtuin 1; WAT, white adiposetissue.

Indexed keywords

LIPID;

CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; CONFERENCE PAPER; DROSOPHILA; EUKARYOTE; FATTY ACID OXIDATION; LIPID COMPOSITION; LIPID STORAGE; LIPOGENESIS; LONGEVITY; NONHUMAN; PEROXISOME; PRIORITY JOURNAL;

AGING; ANIMALS; EUKARYOTIC CELLS; LIPID METABOLISM; ORGANELLES; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 70350149982     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0371050     Document Type: Conference Paper

References (50)

1. Murphy, D.J. (2001) The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog. Lipid Res. 40, 325-438
2. Wältermann, M. and Steinbüchel, A. (2005) Neutral lipid bodies in prokaryotes: recent insights into structure, formation, and relationship to eukaryotic lipid depots. J. Bacteriol. 187, 3607-3619
3. Martin, S. and Parton, R.G. (2005) Caveolin, cholesterol, and lipid bodies. Semin. Cell Dev. Biol. 16, 163-174
4. Fujimoto, T. and Ohsaki, Y. (2006) Cytoplasmic lipid droplets: rediscovery of an old structure as a unique platform. Ann. N.Y. Acad. Sci. 1086, 104-115
5. Martin, S. and Parton, R.G. (2006) Lipid droplets: a unified view of a dynamic organelle. Nat. Rev. Mol. Cell Biol. 7, 373-378
6. Olofsson, S.O., Boström, P., Andersson, L., Rutberg, M., Perman, J. and Borén, J. (2008) Lipid droplets as dynamic organelles connecting storage and efflux of lipids. Biochim. Biophys. Acta 1791, 448-458
7. Czabany, T., Athenstaedt, K. and Daum, G. (2007) Synthesis, storage and degradation of neutral lipids in yeast. Biochim. Biophys. Acta 1771, 299-309
8. Thiele, C. and Spandl, J. (2008) Cell biology of lipid droplets. Curr. Opin. Cell Biol. 20, 378-385
9. Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V.S., Zhao, Y., Gilpin, C., Chapman, K.D., Anderson, R.G. and Goodman, J.M. (2006) An intimate collaboration between peroxisomes and lipid bodies. J. Cell Biol. 173, 719-731
10. Boström, P., Andersson, L., Rutberg, M., Perman, J., Lidberg, U., Johansson, B.R., Fernandez-Rodriguez, J., Ericson, J., Nilsson, T., Borén, J. and Olofsson, S.O. (2007) SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat. Cell Biol. 9, 1286-1293
11. Ducharme, N.A. and Bickel, P.E. (2008) Lipid droplets in lipogenesis and lipolysis. Endocrinology 149, 942-949
12. Dugail, I. and Hajduch, E. (2007) A new look at adipocyte lipid droplets: towards a role in the sensing of triacylglycerol stores? Cell. Mol. Life Sci. 64, 2452-2458
13. Goodman, J.M. (2008) The gregarious lipid droplet. J. Biol. Chem. 283, 28005-28009
14. Guo, Y., Cordes, K.R., Farese, R.V. and Walther, T.C. (2009) Lipid droplets at a glance. J. Cell Sci. 122, 749-752
15. Guo, Y., Walther, T.C., Rao, M., Stuurman, N., Goshima, G., Terayama, K., Wong, J.S., Vale, R.D., Walter, P. and Farese, R.V. (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453, 657-661
16. Kuerschner, L., Moessinger, C. and Thiele, C. (2008) Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic 9, 338-352
17. Robenek, H., Hofnagel, O., Buers, I., Robenek, M.J., Troyer, D. and Severs, N.J. (2006) Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis. J. Cell Sci. 119, 4215-4224
18. Welte, M.A. (2007) Proteins under new management: lipid droplets deliver. Trends Cell Biol. 17, 363-369
19. Zechner, R., Kienesberger, P.C., Haemmerle, G., Zimmermann, R. and Lass, A. (2009) Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J. Lipid Res. 50, 3-21
20. Kurat, C.F., Wolinski, H., Petschnigg, J., Kaluarachchi, S., Andrews, B., Natter, K. and Kohlwein, S.D. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol. Cell 33, 53-63
21. Bordone, L. and Guarente, L. (2005) Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 6, 298-305
22. Rosen, E.D. and Spiegelman, B.M. (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853
23. Guilherme, A., Virbasius, J.V., Puri, V. and Czech, M.P. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367-377
24. Cao, H., Gerhold, K., Mayers, J.R., Wiest, M.M., Watkins, S.M. and Hotamisligil, G.S. (2008) Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134, 933-944
25. Palanker, L., Tennessen, J.M., Lam, G. and Thummel, C.S. (2009) Drosophila HNF4 regulates lipid mobilization and β-oxidation. Cell Metab. 9, 228-239
26. Ohsaki, Y., Cheng, J., Fujita, A., Tokumoto, T. and Fujimoto, T. (2006) Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol. Biol. Cell 17, 2674-2683
27. Jiang, H., He, J., Pu, S., Tang, C. and Xu, G. (2007) Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Biochim. Biophys. Acta 1771, 66-74
28. Cermelli, S., Guo, Y., Gross, S.P. and Welte, M.A. (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr. Biol. 16, 1783-1795
29. Wang, M.C., O'Rourke, E.J. and Ruvkun, G. (2008) Fat metabolism links germline stem cells and longevity in C. elegans. Science 322, 957-960
30. Grönke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Müller, G., Jäckle, H. and Kühnlein, R.P. (2005) Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1, 323-330
31. Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S. et al. (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312, 734-737
32. Blüher, M., Kahn, B.B. and Kahn, C.R. (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574
33. Puigserver, P. and Kahn, C.R. (2008) Mammalian metabolism in aging. in Molecular Biology of Aging (Guarente, L.P., Partridge, L. and Wallace, D.C., eds), pp. 545-574, Cold Spring Harbor Laboratory Press, Cold Spring Harbor
34. Chiu, C.H., Lin, W.D., Huang, S.Y. and Lee, Y.H. (2004) Effect of a C/ EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev. 18, 1970-1975
35. Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., Senawong, T., Machado De Oliveira, R., Leid, M., McBurney, M.W. and Guarente, L. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429, 771-776
36. Gregor, M.F. and Hotamisligil, G.S. (2007) Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48, 1905-1914
37. Russell, S.J. and Kahn, C.R. (2007) Endocrine regulation of ageing. Nat. Rev. Mol. Cell Biol. 8, 681-691
38. Rodgers, J.T., Lerin, C., Gerhart-Hines, Z. and Puigserver, P. (2008) Metabolic adaptations through the PGC-1α and SIRT1 pathways. FEBS Lett. 582, 46-53
39. Olefsky, J.M. (2008) Fat talks, liver and muscle listen. Cell 134, 914-916
40. Lin, S.-J. and Sinclair, D. (2008) Molecular mechanisms of aging: insights from budding yeast. in Molecular Biology of Aging (Guarente, L.P., Partridge, L. and Wallace, D.C., eds), pp. 483-516, Cold Spring Harbor Laboratory Press, Cold Spring Harbor
41. Bitterman, K.J., Medvedik, O. and Sinclair, D.A. (2003) Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol. Mol. Biol. Rev. 67, 376-399
42. Longo, V.D. and Kennedy, B.K. (2006) Sirtuins in aging and age-related disease. Cell 126, 257-268
43. Fabrizio, P., Gattazzo, C., Battistella, L., Wei, M., Cheng, C., McGrew, K. and Longo, V.D. (2005) Sir2 blocks extreme life-span extension. Cell 123, 655-667
44. van der Klei, I.J., Yurimoto, H., Sakai, Y. and Veenhuis, M. (2006) The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim. Biophys. Acta 1763, 1453-1462
45. Hiltunen, J.K., Mursula, A.M., Rottensteiner, H., Wierenga, R.K., Kastaniotis, A.J. and Gurvitz, A. (2003) The biochemistry of peroxisomal β-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol. Rev. 27, 35-64
46. Bener Aksam, E., Jungwirth, H., Kohlwein, S.D., Ring, J., Madeo, F., Veenhuis, M. and van der Klei, I.J. (2008) Absence of the peroxiredoxin Pmp20 causes peroxisomal protein leakage and necrotic cell death. Free Radical Biol. Med. 45, 1115-1124
47. Jungwirth, H., Ring, J., Mayer, T., Schauer, A., Büttner, S., Eisenberg, T., Carmona-Gutierrez, D., Kuchler, K. and Madeo, F. (2008) Loss of peroxisome function triggers necrosis. FEBS Lett. 582, 2882-2886
48. Low, C.P., Liew, L.P., Pervaiz, S. and Yang, H. (2005) Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe. FEMS Yeast Res. 5, 1199-1206
49. Spitaler, M. and Cantrell, D.A. (2004) Protein kinase C and beyond. Nat. Immunol. 5, 785-790
50. Feng, H., Ren, M., Chen, L. and Rubin, C.S. (2007) Properties, regulation and in vivo functions of a novel protein kinase D: C. elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and lifespan. J. Biol. Chem. 282, 31273-31288