Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 β-Lactamase: 1.63 Å Crystal Structure

Biochemistry

Volumn 43, Issue 4, 2004, Pages 843-848

  Padayatti, Pius S ^a   Helfand, Marion S ^c   Totir, Monica A ^b   Carey, Marianne P ^a   Hujer, Andrea M ^c   Carey, Paul R ^a,b   Bonomo, Robert A ^c   Van Den Akker, Focco ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; CHEMICAL BONDS; CRYSTAL STRUCTURE; ENZYME INHIBITION; MICROSCOPIC EXAMINATION; ORGANIC ACIDS; SINGLE CRYSTALS;

ANTIBIOTIC RESISTANCE; FLASH-FREEZING CRYSTALS;

BIOCHEMISTRY;

ANTIBIOTIC AGENT; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CLAVULANIC ACID; ENAMINE; PENICILLIN G; SHV 1 BETA LACTAMASE; SULBACTAM; SULFONE; TAZOBACTAM; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; DEACYLATION; DRUG DEGRADATION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; FREEZING; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; MOLECULAR STABILITY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; STOICHIOMETRY;

EID: 0942290637     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035985m     Document Type: Article

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