Carboxylation and decarboxylation of active site lys 84 controls the activity of OXA-24 β-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence

Journal of the American Chemical Society

Volumn 134, Issue 27, 2012, Pages 11206-11215

  Che, Tao ^a   Bonomo, Robert A ^a,c   Shanmugam, Sivaprakash ^a   Bethel, Christopher R ^c   Pusztai Carey, Marianne ^a   Buynak, John D ^b   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b SOUTHERN METHODIST UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCE SPECTROSCOPY; ACINETOBACTERS; ACTIVE SITE; BAUMANNII; CARBAPENEMS; CHROMOGENIC SUBSTRATE; CLASS-D; CRYSTALLINE STATE; HEPES BUFFER; INHIBITOR DESIGN; INTERMEDIATE SPECIE; LACTAMASES; MODE OF ACTION; NITROCEFIN; NOVEL FUNCTIONS; RAMAN BANDS; RAMAN EXPERIMENTS; RAMAN MICROSCOPY; RAMAN SIGNAL; REACTION CYCLES; REAL TIME; TIME-SCALES; TRANSIENT FEATURES;

AMINO ACIDS; CARBOXYLATION; CRYSTALLINE MATERIALS; ENZYME INHIBITION; RAMAN SPECTROSCOPY; SINGLE CRYSTALS;

REACTION INTERMEDIATES;

BETA LACTAMASE; LYSINE; NITROCEFIN;

ACINETOBACTER BAUMANNII; AQUEOUS SOLUTION; ARTICLE; CARBOXYLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLOGRAPHY; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR MECHANICS; NONHUMAN; RAMAN SPECTROMETRY;

ACINETOBACTER BAUMANNII; BETA-LACTAMASES; CATALYTIC DOMAIN; CEPHALOSPORINS; DECARBOXYLATION; ENZYME INHIBITORS; LYSINE; SPECTRUM ANALYSIS, RAMAN;

EID: 84863837183     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja303168n     Document Type: Article

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