Ultrahigh resolution structure of a class A β-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme

Journal of Molecular Biology

Volumn 328, Issue 1, 2003, Pages 289-301

  Nukaga, Michiyoshi ^a   Mayama, Kayoko ^a   Hujer, Andrea M ^b   Bonomo, Robert A ^b   Knox, James R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

Catalytic mechanism; Enzyme structure; Radiation damage; X ray crystallography

Indexed keywords

ANTIBIOTIC AGENT; ASPARAGINE; BACTERIAL ENZYME; BETA LACTAMASE; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; ENZYME; GLUTAMINE; GLYCINE; HYDROGEN; HYDROXIDE; LYSINE; PENICILLIN G; SERINE;

ACYLATION; ARTICLE; ATOMIC PARTICLE; BINDING SITE; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; HYDROLYSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ANALYSIS; WILD TYPE;

BACTERIA (MICROORGANISMS);

EID: 0037453313     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00210-9     Document Type: Article

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