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Volumn 348, Issue 1, 2014, Pages 12-24

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cellss

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BUDESONIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXAMETHASONE; FLUTICASONE PROPIONATE; FORMOTEROL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INTERLEUKIN 8; MESSENGER RNA; RGS2 PROTEIN; SALMETEROL;

EID: 84890447102     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.204586     Document Type: Article
Times cited : (40)

References (63)
  • 1
    • 70350534804 scopus 로고    scopus 로고
    • Glucocorticoid-induced leucine zipper (gilz): A new important mediator of glucocorticoid action
    • Ayroldi E and Riccardi C (2009) Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action. FASEB J 23:3649-3658.
    • (2009) FASEB J , vol.23 , pp. 3649-3658
    • Ayroldi, E.1    Riccardi, C.2
  • 5
    • 33751099074 scopus 로고    scopus 로고
    • Analysis of the dissociated steroid ru24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids
    • Chivers JE, Gong W, King EM, Seybold J, Mak JC, Donnelly LE, Holden NS, and Newton R (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Mol Pharmacol 70:2084-2095.
    • (2006) Mol Pharmacol , vol.70 , pp. 2084-2095
    • Chivers, J.E.1    Gong, W.2    King, E.M.3    Seybold, J.4    Mak, J.C.5    Donnelly, L.E.6    Holden, N.S.7    Newton, R.8
  • 6
    • 54449097818 scopus 로고    scopus 로고
    • Role of dual specificity phosphatases in biological responses to glucocorticoids
    • Clark AR, Martins JR, and Tchen CR (2008) Role of dual specificity phosphatases in biological responses to glucocorticoids. J Biol Chem 283:25765-25769.
    • (2008) J Biol Chem , vol.283 , pp. 25765-25769
    • Clark, A.R.1    Martins, J.R.2    Tchen, C.R.3
  • 7
    • 0032004232 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: Characterization of isoenzymes and functional effects of pde inhibitors
    • Dent G, White SR, Tenor H, Bodtke K, Schudt C, Leff AR, Magnussen H, and Rabe KF (1998) Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors. Pulm Pharmacol Ther 11:47-56.
    • (1998) Pulm Pharmacol Ther , vol.11 , pp. 47-56
    • Dent, G.1    White, S.R.2    Tenor, H.3    Bodtke, K.4    Schudt, C.5    Leff, A.R.6    Magnussen, H.7    Rabe, K.F.8
  • 8
    • 48249111889 scopus 로고    scopus 로고
    • Restriction to fos family members of trip6- dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1
    • Diefenbacher M, Sekula S, Heilbock C, Maier JV, Litfin M, van Dam H, Castellazzi M, Herrlich P, and Kassel O (2008) Restriction to Fos family members of Trip6- dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. Mol Endocrinol 22:1767-1780.
    • (2008) Mol Endocrinol , vol.22 , pp. 1767-1780
    • Diefenbacher, M.1    Sekula, S.2    Heilbock, C.3    Maier, J.V.4    Litfin, M.5    Van Dam, H.6    Castellazzi, M.7    Herrlich, P.8    Kassel, O.9
  • 9
    • 33646452550 scopus 로고    scopus 로고
    • Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells
    • Edwards MR, Johnson MW, and Johnston SL (2006) Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 34:616-624.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 616-624
    • Edwards, M.R.1    Johnson, M.W.2    Johnston, S.L.3
  • 10
    • 0030841890 scopus 로고    scopus 로고
    • Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo
    • Esmailpour N, Högger P, Rabe KF, Heitmann U, Nakashima M, and Rohdewald P (1997) Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo. Eur Respir J 10:1496-1499.
    • (1997) Eur Respir J , vol.10 , pp. 1496-1499
    • Esmailpour, N.1    Högger, P.2    Rabe, K.F.3    Heitmann, U.4    Nakashima, M.5    Rohdewald, P.6
  • 12
    • 0037122432 scopus 로고    scopus 로고
    • Role of histamine in the pathophysiology of asthma: Immunomodulatory and anti-inflammatory activities of h1-receptor antagonists
    • Gelfand EW (2002) Role of histamine in the pathophysiology of asthma: immunomodulatory and anti-inflammatory activities of H1-receptor antagonists. Am J Med 113 (Suppl 9A):2S-7S.
    • (2002) Am J Med , vol.113 , Issue.SUPPL. 9A
    • Gelfand, E.W.1
  • 13
    • 40949165358 scopus 로고    scopus 로고
    • A holy grail of asthma management: Toward understanding how long-acting b2-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids
    • Giembycz MA, Kaur M, Leigh R, and Newton R (2008) A holy grail of asthma management: toward understanding how long-acting b2-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol 153: 1090-1104.
    • (2008) Br J Pharmacol , vol.153 , pp. 1090-1104
    • Giembycz, M.A.1    Kaur, M.2    Leigh, R.3    Newton, R.4
  • 14
    • 33750742437 scopus 로고    scopus 로고
    • Beyond the dogma: Novel b2-adrenoceptor signalling in the airways
    • Giembycz MA and Newton R (2006) Beyond the dogma: novel b2-adrenoceptor signalling in the airways. Eur Respir J 27:1286-1306.
    • (2006) Eur Respir J , vol.27 , pp. 1286-1306
    • Giembycz, M.A.1    Newton, R.2
  • 15
    • 33745218112 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in the pathophysiology of asthma and copd
    • Gosens R, Zaagsma J, Meurs H, and Halayko AJ (2006) Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 7:73.
    • (2006) Respir Res , vol.7 , pp. 73
    • Gosens, R.1    Zaagsma, J.2    Meurs, H.3    Halayko, A.J.4
  • 16
    • 84882336794 scopus 로고    scopus 로고
    • Concurrent agonism of adenosine a2b and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: A novel approach to treat chronic obstructive pulmonary disease
    • Greer S, Page CW, Joshi T, Yan D, Newton R, and Giembycz MA (2013) Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease. J Pharmacol Exp Ther 346: 473-485.
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 473-485
    • Greer, S.1    Page, C.W.2    Joshi, T.3    Yan, D.4    Newton, R.5    Giembycz, M.A.6
  • 17
    • 34447289205 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in the airways: An unappreciated regulatory role in pulmonary inflammation?
    • Gwilt CR, Donnelly LE, and Rogers DF (2007) The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation? Pharmacol Ther 115:208-222.
    • (2007) Pharmacol Ther , vol.115 , pp. 208-222
    • Gwilt, C.R.1    Donnelly, L.E.2    Rogers, D.F.3
  • 20
    • 4344678297 scopus 로고    scopus 로고
    • Rgs2-mediated regulation of gqa
    • Heximer SP (2004) RGS2-mediated regulation of Gqa. Methods Enzymol 390: 65-82.
    • (2004) Methods Enzymol , vol.390 , pp. 65-82
    • Heximer, S.P.1
  • 21
    • 44449153085 scopus 로고    scopus 로고
    • Molecular characterization of helicobacter pylori vaca induction of il-8 in u937 cells reveals a prominent role for p38mapk in activating transcription factor-2, camp response element binding protein, and nf-kb activation
    • Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, and Yamasaki E, et al. (2008) Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kB activation. J Immunol 180: 5017-5027.
    • (2008) J Immunol , vol.180 , pp. 5017-5027
    • Hisatsune, J.1    Nakayama, M.2    Isomoto, H.3    Kurazono, H.4    Mukaida, N.5    Mukhopadhyay, A.K.6    Azuma, T.7    Yamaoka, Y.8    Sap, J.9    Yamasaki, E.10
  • 23
    • 36048955411 scopus 로고    scopus 로고
    • Potentiation of nf-kb-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells
    • Holden NS, Gong W, King EM, Kaur M, Giembycz MA, and Newton R (2007) Potentiation of NF-kB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br J Pharmacol 152:891-902.
    • (2007) Br J Pharmacol , vol.152 , pp. 891-902
    • Holden, N.S.1    Gong, W.2    King, E.M.3    Kaur, M.4    Giembycz, M.A.5    Newton, R.6
  • 24
    • 0037246364 scopus 로고    scopus 로고
    • Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
    • discussion S34-S36
    • Holgate ST, Peters-Golden M, Panettieri RA, and Henderson WR, Jr. (2003) Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 111(1, Suppl)S18-S34, discussion S34-S36.
    • (2003) J Allergy Clin Immunol , vol.111 , Issue.1 SUPPL.
    • Holgate, S.T.1    Peters-Golden, M.2    Panettieri, R.A.3    Henderson Jr., W.R.4
  • 25
    • 24744434955 scopus 로고    scopus 로고
    • Comparative measurement of thromboxane a2 metabolites in exhaled breath condensate by different immunoassays
    • Huszár E, Szabó Z, Jakab A, Barta I, Herjavecz I, and Horváth I (2005) Comparative measurement of thromboxane A2 metabolites in exhaled breath condensate by different immunoassays. Inflamm Res 54:350-355.
    • (2005) Inflamm Res , vol.54 , pp. 350-355
    • Huszár, E.1    Szabó, Z.2    Jakab, A.3    Barta, I.4    Herjavecz, I.5    Horváth, I.6
  • 27
    • 69249211014 scopus 로고    scopus 로고
    • Prostanoid receptor antagonists: Development strategies and therapeutic applications
    • Jones RL, Giembycz MA, and Woodward DF (2009) Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol 158: 104-145.
    • (2009) Br J Pharmacol , vol.158 , pp. 104-145
    • Jones, R.L.1    Giembycz, M.A.2    Woodward, D.F.3
  • 28
    • 37349117437 scopus 로고    scopus 로고
    • Long-acting b2- adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells
    • Kaur M, Chivers JE, Giembycz MA, and Newton R (2008) Long-acting b2- adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol 73:203-214.
    • (2008) Mol Pharmacol , vol.73 , pp. 203-214
    • Kaur, M.1    Chivers, J.E.2    Giembycz, M.A.3    Newton, R.4
  • 31
    • 70350351542 scopus 로고    scopus 로고
    • Inhibition of nf-kbdependent transcription by mkp-1: Transcriptional repression by glucocorticoids occurring via p38 mapk
    • King EM, Holden NS, Gong W, Rider CF, and Newton R (2009) Inhibition of NF-kBdependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. J Biol Chem 284:26803-26815.
    • (2009) J Biol Chem , vol.284 , pp. 26803-26815
    • King, E.M.1    Holden, N.S.2    Gong, W.3    Rider, C.F.4    Newton, R.5
  • 32
    • 84872316647 scopus 로고    scopus 로고
    • Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms
    • King EM, Chivers JE, Rider CF, Minnich A, Giembycz MA, and Newton R (2013) Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms. PLoS ONE 8:e53936.
    • (2013) PLoS ONE , vol.8
    • King, E.M.1    Chivers, J.E.2    Rider, C.F.3    Minnich, A.4    Giembycz, M.A.5    Newton, R.6
  • 33
    • 0346888342 scopus 로고    scopus 로고
    • The airway epithelium: Structural and functional properties in health and disease
    • Knight DA and Holgate ST (2003) The airway epithelium: structural and functional properties in health and disease. Respirology 8:432-446.
    • (2003) Respirology , vol.8 , pp. 432-446
    • Knight, D.A.1    Holgate, S.T.2
  • 34
    • 0026697298 scopus 로고
    • Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity
    • Koyama S, Rennard SI, and Robbins RA (1992) Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Physiol 262:L466-L471.
    • (1992) Am J Physiol , vol.262
    • Koyama, S.1    Rennard, S.I.2    Robbins, R.A.3
  • 35
    • 0031957332 scopus 로고
    • Acetylcholine and substance p stimulate bronchial epithelial cells to release eosinophil chemotactic activity
    • Koyama S, Sato E, Nomura H, Kubo K, Nagai S, and Izumi T (1998) Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity. J Appl Physiol (1985) 84:1528-1534.
    • (1985) J Appl Physiol , vol.1998 , Issue.84 , pp. 1528-1534
    • Koyama, S.1    Sato, E.2    Nomura, H.3    Kubo, K.4    Nagai, S.5    Izumi, T.6
  • 36
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM and Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 38
    • 33645470600 scopus 로고    scopus 로고
    • Histamine h1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase c
    • Matsubara M, Ohmori K, and Hasegawa K (2006) Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. Int Arch Allergy Immunol 139:279-293.
    • (2006) Int Arch Allergy Immunol , vol.139 , pp. 279-293
    • Matsubara, M.1    Ohmori, K.2    Hasegawa, K.3
  • 39
    • 2142650641 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery and expression of a camp-dependent protein kinase inhibitor gene to beas-2b epithelial cells abolishes the antiinflammatory effects of rolipram, salbutamol, and prostaglandin e2: A comparison with h-89
    • Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, and Giembycz MA (2004) Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the antiinflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. J Pharmacol Exp Ther 309:833-844.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 833-844
    • Meja, K.K.1    Catley, M.C.2    Cambridge, L.M.3    Barnes, P.J.4    Lum, H.5    Newton, R.6    Giembycz, M.A.7
  • 40
    • 0036606268 scopus 로고    scopus 로고
    • No evidence of glucocorticosteroid-induced apoptosis of airway epithelial cells in vivo
    • author reply 1567-1568
    • Miller-Larsson A and Selroos O (2002) No evidence of glucocorticosteroid- induced apoptosis of airway epithelial cells in vivo. Am J Respir Crit Care Med 165: 1567-1568, author reply 1567-1568.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1567-1568
    • Miller-Larsson, A.1    Selroos, O.2
  • 41
    • 84875473420 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: A novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease
    • Moodley T, Wilson SM, Joshi T, Rider CF, Sharma P, Yan D, Newton R, and Giembycz MA (2013) Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: a novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease. Mol Pharmacol 83:894-906.
    • (2013) Mol Pharmacol , vol.83 , pp. 894-906
    • Moodley, T.1    Wilson, S.M.2    Joshi, T.3    Rider, C.F.4    Sharma, P.5    Yan, D.6    Newton, R.7    Giembycz, M.A.8
  • 43
    • 84893725127 scopus 로고    scopus 로고
    • Anti-inflammatory glucocorticoids: Changing concepts
    • DOI: 10.1016/j.ejphar.2013.05.035 [published ahead of print].
    • Newton R (2013) Anti-inflammatory glucocorticoids: changing concepts. Eur J Pharmacol DOI: 10.1016/j.ejphar.2013.05.035 [published ahead of print].
    • (2013) Eur J Pharmacol
    • Newton, R.1
  • 44
    • 34748920671 scopus 로고    scopus 로고
    • Separating transrepression and transactivation: A distressing divorce for the glucocorticoid receptor?
    • Newton R and Holden NS (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Mol Pharmacol 72: 799-809.
    • (2007) Mol Pharmacol , vol.72 , pp. 799-809
    • Newton, R.1    Holden, N.S.2
  • 45
    • 34247222126 scopus 로고    scopus 로고
    • Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule ikb kinase inhibitors
    • Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, and Barnes PJ (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkB kinase inhibitors. J Pharmacol Exp Ther 321: 734-742.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 734-742
    • Newton, R.1    Holden, N.S.2    Catley, M.C.3    Oyelusi, W.4    Leigh, R.5    Proud, D.6    Barnes, P.J.7
  • 46
    • 77950872531 scopus 로고    scopus 로고
    • Glucocorticoids inhibit il-1b-induced gm-csf expression at multiple levels: Roles for the erk pathway and repression by mkp-1
    • Newton R, King EM, Gong W, Rider CF, Staples KJ, Holden NS, and Bergmann MW (2010a) Glucocorticoids inhibit IL-1b-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1. Biochem J 427: 113-124.
    • (2010) Biochem J , vol.427 , pp. 113-124
    • Newton, R.1    King, E.M.2    Gong, W.3    Rider, C.F.4    Staples, K.J.5    Holden, N.S.6    Bergmann, M.W.7
  • 47
    • 77349101801 scopus 로고    scopus 로고
    • Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases
    • Newton R, Leigh R, and Giembycz MA (2010b) Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases. Pharmacol Ther 125:286-327.
    • (2010) Pharmacol Ther , vol.125 , pp. 286-327
    • Newton, R.1    Leigh, R.2    Giembycz, M.A.3
  • 48
    • 0033899452 scopus 로고    scopus 로고
    • Synergistic inhibition by b2-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells
    • Pang L and Knox AJ (2000) Synergistic inhibition by b2-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol 23:79-85.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 79-85
    • Pang, L.1    Knox, A.J.2
  • 49
    • 1842370350 scopus 로고    scopus 로고
    • Formoterol corticosteroids establishing therapy (FACET) group I.S. Effect of inhaled formoterol and budesonide on exacerbations of asthma
    • Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, and Ullman A; Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group (1997) Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 337:1405-1411.
    • (1997) N Engl J Med , vol.337 , pp. 1405-1411
    • Pauwels, R.A.1    Löfdahl, C.G.2    Postma, D.S.3    Tattersfield, A.E.4    O'Byrne, P.5    Barnes, P.J.6    Ullman, A.7
  • 50
    • 37849018276 scopus 로고    scopus 로고
    • Regulation of heterotrimeric g protein signaling in airway smooth muscle
    • Penn RB and Benovic JL (2008) Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc 5:47-57.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 47-57
    • Penn, R.B.1    Benovic, J.L.2
  • 52
    • 34548660457 scopus 로고    scopus 로고
    • Global initiative for chronic obstructive lung disease global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: Gold executive summary
    • Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, and van Weel C, et al.; Global Initiative for Chronic Obstructive Lung Disease (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176:532-555.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 532-555
    • Rabe, K.F.1    Hurd, S.2    Anzueto, A.3    Barnes, P.J.4    Buist, S.A.5    Calverley, P.6    Fukuchi, Y.7    Jenkins, C.8    Rodriguez-Roisin, R.9    Van Weel, C.10
  • 53
    • 80052153018 scopus 로고    scopus 로고
    • Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: Rescue by long-acting b2-adrenoceptor agonists
    • Rider CF, King EM, Holden NS, Giembycz MA, and Newton R (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting b2-adrenoceptor agonists. J Pharmacol Exp Ther 338:860-869.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 860-869
    • Rider, C.F.1    King, E.M.2    Holden, N.S.3    Giembycz, M.A.4    Newton, R.5
  • 54
    • 33845945903 scopus 로고    scopus 로고
    • Up-regulation of endogenous rgs2 mediates crossdesensitization between gs and gq signaling in osteoblasts
    • Roy AA, Nunn C, Ming H, Zou MX, Penninger J, Kirshenbaum LA, Dixon SJ, and Chidiac P (2006) Up-regulation of endogenous RGS2 mediates crossdesensitization between Gs and Gq signaling in osteoblasts. J Biol Chem 281: 32684-32693.
    • (2006) J Biol Chem , vol.281 , pp. 32684-32693
    • Roy, A.A.1    Nunn, C.2    Ming, H.3    Zou, M.X.4    Penninger, J.5    Kirshenbaum, L.A.6    Dixon, S.J.7    Chidiac, P.8
  • 55
    • 78650313173 scopus 로고    scopus 로고
    • Muscarinic receptors as targets for anti-inflammatory therapy
    • Sales ME (2010) Muscarinic receptors as targets for anti-inflammatory therapy. Curr Opin Investig Drugs 11:1239-1245.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1239-1245
    • Sales, M.E.1
  • 56
    • 0034690661 scopus 로고    scopus 로고
    • Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (miasma
    • Shrewsbury S, Pyke S, and Britton M (2000) Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ 320:1368-1373.
    • (2000) BMJ , vol.320 , pp. 1368-1373
    • Shrewsbury, S.1    Pyke, S.2    Britton, M.3
  • 60
    • 0036247381 scopus 로고    scopus 로고
    • Parathyroid hormone induces rgs-2 expression by a cyclic adenosine 39,59- monophosphate-mediated pathway in primary neonatal murine osteoblasts
    • Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O, and Tetradis S (2002) Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 39,59- monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 30:677-684.
    • (2002) Bone , vol.30 , pp. 677-684
    • Tsingotjidou, A.1    Nervina, J.M.2    Pham, L.3    Bezouglaia, O.4    Tetradis, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.