Molecular characterization of Helicobacter pylori vacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-κB Activation

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 5017-5027

  Hisatsune, Junzo ^a   Nakayama, Masaaki ^a   Isomoto, Hajime ^a   Kurazono, Hisao ^b   Mukaida, Naofumi ^c   Mukhopadhyay, Asish K ^a,h   Azuma, Takeshi ^d   Yamaoka, Yoshio ^e   Sap, Jan ^f   Yamasaki, Eiki ^g   Yahiro, Kinnosuke ^g   Moss, Joel ^g   Hirayama, Toshiya ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d KOBE UNIVERSITY   (Japan)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^h NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROENENITRILE); 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING TRANSCRIPTION FACTOR 2; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DANTROLENE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRILE; THAPSIGARGIN; TRANSCRIPTION FACTOR II; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VACUOLATING TOXIN; 1 (2 (3 (4 METHOXYPHENYL)PROPOXY) 4 METHOXYPHENYLETHYL) 1H IMIDAZOLE; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; ATF2 PROTEIN, HUMAN; BACTERIAL PROTEIN; BUTYLATED HYDROXYANISOLE; DRUG DERIVATIVE; EGTAZIC ACID; IMIDAZOLE DERIVATIVE; SULFONE; VACA PROTEIN, HELICOBACTER PYLORI;

ARTICLE; BINDING SITE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GASTRITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; MUTATION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; ACTIVE TRANSPORT; BIOSYNTHESIS; CELL NUCLEUS; CELL STRAIN U937; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; PHOSPHORYLATION; SECRETION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVE TRANSPORT, CELL NUCLEUS; BACTERIAL PROTEINS; BUTYLATED HYDROXYANISOLE; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DANTROLENE; EGTAZIC ACID; ENZYME ACTIVATION; HELICOBACTER PYLORI; HUMANS; IMIDAZOLES; INTERLEUKIN-8; NF-KAPPA B; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SULFONES; THAPSIGARGIN; U937 CELLS; UP-REGULATION;

EID: 44449153085     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.5017     Document Type: Article

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