Glucocorticoids inhibit IL-1β-induced GM-CSF expression at multiple levels: Roles for the ERK pathway and repression by MKP-1

Biochemical Journal

Volumn 427, Issue 1, 2010, Pages 113-124

  Newton, Robert ^a   King, Elizabeth M ^a   Gong, Wei ^b   Rider, Christopher F ^a   Staples, Karl J ^c   Holden, Neil S ^a   Bergmann, Martin W ^d,e  

^a UNIVERSITY OF CALGARY   (Canada)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d FRANZ VOLHARD CLINIC   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Corticosteroid; Dual specificity phosphatase 1 (DUSP1); Epithelial cell; Granulocyte macrophage colony stimulating factor (GM CSF); Inflammation; Mitogen activated protein kinase (MAPK)

Indexed keywords

A549 CELLS; ACTINOMYCIN D; COLONY-STIMULATING FACTOR; CULTURE MEDIUM; CYTOSOLIC; DEXAMETHASONES; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED KINASE; GLUCOCORTICOIDS; IN-CELL; KINASE INHIBITORS; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPLE LEVELS; NUCLEAR RNA; OVER-EXPRESSION; POST-TRANSCRIPTIONAL; PROTEIN SYNTHESIS; SMALL INTERFERING RNA;

CELL CULTURE; CELLS; ENZYME ACTIVITY; PATHOLOGY; PHOSPHATASES; PHOSPHORYLATION; PROTEINS; RNA; TRANSCRIPTION;

DRUG PRODUCTS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DACTINOMYCIN; DEXAMETHASONE; GLUCOCORTICOID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEAR RNA; RU 24858; SMALL INTERFERING RNA; STEROID; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYCLOHEXIMIDE; DUSP1 PROTEIN, HUMAN; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN SYNTHESIS INHIBITOR;

ARTICLE; BRONCHUS MUCOSA; CANCER CELL; CELL LYSATE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; TRANSLATION REGULATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; EPITHELIUM CELL; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOHEXIMIDE; DACTINOMYCIN; DEXAMETHASONE; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME INHIBITORS; ENZYME REPRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-1BETA; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77950872531     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091038     Document Type: Article

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