Concurrent agonism of adenosine a2b and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: A novel approach to treat chronic obstructive pulmonary disease

Journal of Pharmacology and Experimental Therapeutics

Volumn 346, Issue 3, 2013, Pages 473-485

  Greer, Stephanie ^a   Page, Cara W ^a   Joshi, Taruna ^a   Yan, Dong ^a   Newton, Robert ^a   Giembycz, Mark A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 [6 AMINO 3,5 DICYANO 4 [4 (CYCLOPROPYLMETHOXY)PHENYL]PYRIDIN 2 YLSULPHANYL]ACETAMIDE; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; BAY 60 6583; CD200 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; RGS2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRL 1 GENE; CD200 GENE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRISPLD2 GENE; CYCLIN DEPENDENT KINASE INHIBITOR 1C GENE; DRUG MECHANISM; DRUG POTENTIATION; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RGS2 GENE; SOCS3 GENE; TRANSCRIPTION INITIATION; TTP GENE;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ALGORITHMS; AMINOPYRIDINES; CALCIUM; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYTOSOL; DEXAMETHASONE; EPITHELIAL CELLS; HUMANS; INFLAMMATION; PHENETHYLAMINES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ADENOSINE A2B; RECEPTORS, GLUCOCORTICOID; RESPIRATORY MUCOSA; RNA, MESSENGER; TRANSFECTION;

EID: 84882336794     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.206284     Document Type: Article

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