Willow bark extract: The contribution of polyphenols to the overall effect

Wiener Medizinische Wochenschrift

Volumn 157, Issue 13-14, 2007, Pages 348-351

  Nahrstedt, Adolf ^a   Schmidt, Mathias ^b   Jäggi, René ^c   Metz, Jürgen ^d   Khayyal, Mohamed T ^e  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Herbresearch ^*  (Germany)

^c Skyepharma   (Switzerland)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e Pharmaceutical Chemistry Department   (Egypt)

Author keywords

Efficacy; Flavonoids; Polyphenols; Salicaceae; Salicin; Salix sp.; Willow bark

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; DRUG METABOLITE; FLAVONOID; FREE RADICAL; POLYPHENOL DERIVATIVE; SALICIN; SALIX EXTRACT;

ARTICLE; BACKACHE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; RHEUMATOID ARTHRITIS; WILLOW;

ANIMALS; ARTHRITIS; BACK PAIN; BENZYL ALCOHOLS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; FLAVONOIDS; HUMANS; MICE; PHENOLS; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; RATS; SALIX; TIME FACTORS;

EID: 34548410990     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-007-0437-3     Document Type: Article

References (18)

1. Willow bark. Salicis cortex (2005) European Pharmacopoeia 5.2, Conseil d'Europe, Strasbourg, France, pp 2702-2703
2. März RW, Kemper F (2002) Weidenrindenextrakt - Wirkungen und Wirksamkeit. Erkenntnisstand zu Pharmakologie, Toxikologie und Klinik. Wien Med Wochenschr 152: 354-359
3. Salicis cortex. Willow bark (2003) In: European Scientific Cooperative on Phytotherapy (ed). E/S/C/O/P Monographs. The Scientific Foundation for Herbal Medicinal Products, Georg Thieme-Verlag, Stuttgart, New York, pp 445-451
4. Shao Y (1991) Phytochemischer Atlas der Schweizer Weiden, Dissertation. University of Zürich (CH)
5. Jürgenliemk G, Petereit F, Nahrstedt A (2007) Flavan-3-ols and procyanidins from the bark of Salix purpurea L. Pharmazie 62: 231-234
6. Mayer RA, Mayer M (1949) Biologische Salicyltherapie mit Cortex Salicis. Pharmazie 4: 77-81
7. Lardos A, Schmidlin CB, Fischer M, Ferlas-Chlodny E, Loniewski I, Samochoviec L et al (2004) Wirksamkeit und Verträglichkeit eines wässrig ausgezogenen Weidenrindenextraktes bei Patienten mit Hüft- und Kniearthrose. Z Phytother 25: 275-281
8. Jäggi R, Büter B, Grandjean F, Berger-Büter K, Kelber O, Bidlingmaier B et al (2003) Osteoarthritis and inflammation: Multiple target inhibition with the willow bark extract STW 33-I in vitro. P125. Osteoarthritis Cartilage 11: S46
9. Fiebich BL, Klin J, Zeller K, Weiser D (2003) Anti-inflammatory effects of Salix: Salix extracts as inhibitors of the expression and synthesis of cytokines, matrix-metalloproteases, prostaglandins and COX-2 in LPS-treated primary human monocytes and chrondrocytes. Osteoarthritis Cartilage 11: S119-P332
10. Kelber O, Bonaterra GA, Kinscherf R, Weiser D, Metz J (2006) Inhibitorische Effekte von Weidenrindenextrakten auf proinflammatorische Prozesse in LPS-aktivierten Humanmonozyten. Z Rheumatol 65(Suppl 1): S31
11. Bonaterra GA, Kelber O, Kinscherf R, Harsch J, Weiser D, Metz J (2004) Anti-inflammatory effects of willow bark extract STW 33-1 (fraction E) in lipopolysaccharide activated human monocytes. Arch Pharmacol 369(Suppl 1) R10
12. Hässig A, Liang WX, Schwabl H, Stampfli K (1999) Flavonoids and tannins: plant-based antioxidants with vitamin character. Med Hypotheses 52: 479-481
13. Yoon JH, Baek SJ (2005) Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J 46: 585-596
14. Germann I (2005) Charakterisierung der radikalfangenden Eigenschaften pflanzlicher Entzündungshemmer. Eberhard-Karls-Universität, Tübingen
15. Khayyal MT, El Ghazaly MA, Kelber O, Okpany SN, Weiser D (2003) The anti-inflammatory, antipyretic and analgesic effect of willow bark extract, STW 33-I, can not be explained solely on the basis of its salicin content. Osteoarthritis Cartilage 11: S69-P192
16. Khayyal MT, El Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D (2005) Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittelforschung 55: 677-687
17. Müller J, Kelber O, Weiser D (2005) Weidenrindenpräparat (Rheumakaps) bei rheumatischen Beschwerden - ein Erfahrungsbericht. Z Phytother 26: 31
18. Hostanka K, Jürgenliemk G, Abel G, Nahrstedt A, Saller R (2007) Willow bark extract (BNO 1455) and its fractions suppress growth and induce apoptosis in human colon and lung cancer cells. Cancer Detect Prev 31: 129-139