Flavonoids, derived from traditional chinese medicines, show roles in the differentiation of neurons: Possible targets in developing health food products

Birth Defects Research Part C - Embryo Today: Reviews

Volumn 99, Issue 4, 2013, Pages 292-299

  Xu, Sherry L ^a   Zhu, Kevin Y ^b   Bi, Cathy W C ^a   Yan, Lu ^a   Men, Simon W X ^a   Dong, Tina T X ^a   Tsim, Karl W K ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Flavonoid; Herbal medicine; Nervous system; Neurite outgrowth; Neuronal plasticity; Neuronal stem cell

Indexed keywords

AGLYCONE; APIGENIN; ASTRAGALIN; AURAPTENE; BAICALEIN; BAICALIN; CHRYSIN; DAIDZEIN; FLAVONE; FLAVONOID; FLAVONOL; GALANGIN; GARCINOL; GENISTEIN; GLYCITEIN; HESPERIDIN; ISOFLAVONE; ISORHAMNETIN; ISOVITEXIN; KAEMPFEROL; LUTEOLIN; PHLORETIN; PHLORIZIN; PUERARIN; QUERCETIN; RUTOSIDE; SCUTELLARIN; SILIBININ; TECTORIGENIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; BIOLOGICAL ACTIVITY; CELL VIABILITY; CHINESE MEDICINE; CITRON; DRUG EFFECT; GENE EXPRESSION; HUMAN; LEMON; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NEURAL STEM CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; REVIEW; SCUTELLARIA BAICALENSIS; SOYBEAN;

FLAVONOID; HERBAL MEDICINE; NERVOUS SYSTEM; NEURITE OUTGROWTH; NEURONAL PLASTICITY; NEURONAL STEM CELL;

CELL DIFFERENTIATION; FLAVONOIDS; HUMANS; MEDICINE, CHINESE TRADITIONAL; NEURITES; STEM CELLS;

EID: 84890372098     PISSN: 1542975X     EISSN: 15429768     Source Type: Journal    
DOI: 10.1002/bdrc.21054     Document Type: Review

References (59)

1. Abd El Mohsen MM, Kuhnle G, Rechner AR, et al. 2002. Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic Biol Med 33:1693-1702.
2. An L, Zhang YZ, Yu NJ, et al. 2008. The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats. Prog Neuro-Psychopharmacol Biol Psychiatry 32:1484-1490.
3. Beecher GR. 2003. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133:3248S-3254S.
4. Cassidy A, Rimm EB, O'Reilly EJ, et al. 2012. Dietary flavonoids and risk of stroke in women. Stroke 43:946-951.
5. Choi RCY, Zhu JTT, Leung KW, et al. 2010. A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-β-induced neurotoxicity in cultured neurons: signaling transduction and drug development for Alzheimer's disease. J Alzheimer's Dis 19:795-811.
6. Choi RCY, Zhu JTT, Yung AWY, et al. 2013. Synergistic action of flavonoids, baicalein, and daidzein in estrogenic and neuroprotective effects: a development of potential health products and therapeutic drugs against alzheimer's disease. Evidence Complementary Alternative Med 2013:635694.
7. DeFeudis FV. 2003. A brief history of EGb 761® and its therapeutic uses. Pharmacopsychiatry 36:S2-S7.
8. Dunnick JK, Hailey JR. 1992. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol 19:423-431.
9. Furukawa Y, Watanabe S, Okuyama S, et al. 2012. Neurotrophic effect of Citrus auraptene: neuritogenic activity in PC12 cells. Int J Mol Sci 13:5338-5347.
10. Galati G, O'Brien PJ. 2004. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37:287-303.
11. Guo AJY, Choi RCY, Cheung AWH, et al. 2011. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/βcatenin signaling pathway. J Biol Chem 286:27882-27893.
12. Harborne JB, Williams CA. 2000. Advances in flavonoid research since 1992. Phytochemistry 55:481-504.
13. Hosseini SA, Meimandipour A, Alami F, et al. 2013. Effects of ground thyme and probiotic supplements in diets on broiler performance, blood biochemistry and immunological response to sheep red blood cells. Italian J Anim Sci 12:116-120.
14. Hu P, Wang M, Chen WH, et al. 2008. Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo. Naunyn-Schmiedeberg's Arch Pharmacol 378:43-51.
15. Jia H, Wang Y, Tong XJ, et al. 2012. Sciatic nerve repair by acellular nerve xenografts implanted with BMSCs in rats xenograft combined with BMSCs. Synapse 66:256-269.
16. Jung WY, Park SJ, Park DH, et al. 2010. Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression. Toxicol Lett 197:97-105.
17. Kessler M, Ubeaud G, Jung L. 2003. Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 55:131-142.
18. Kretz O, Fester L, Wehrenberg U, etal. 2004. Hippocampal synapses depend on hippocampal estrogen synthesis. J Neurosci 24:5913-5921.
19. Lai HY, Liao LD, Lin CT, et al. 2012. Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording. J Neural Eng 9:036001.
20. Lee S, Kim DH, Lee DH, et al. 2010. Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. Neurochem Res 35:1725-1732.
21. Lee SH, Ahn BS, Lim BS, et al. 2011. Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats. Neural Regen Res 6:2085-2093.
22. Li Y, Zhuang P, Shen B, et al. 2012. Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Res 1429:36-42.
23. Liao KK, Wu MJ, Chen PY, et al. 2012. Curcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK- and PKC-dependent pathways. J Agric Food Chem 60:433-443.
24. Lim JS, Yoo M, Kwon HJ, et al. 2010. Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochem Biophys Res Commun 402:42-47.
25. Maher P, Akaishi T, Abe K. 2006. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci USA 103:16568-16573.
26. Manach C, Scalbert A, Morand C, et al. 2004. Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727-747.
27. Marc DB, Nobutaka H, UWE W. 2009. Encyclopedia of neuiroscience. London: Springer. p. 2606.
28. Matsuzaki K, Kenichi M, Sakai S, et al. 2008. Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. Eur J Pharmacol 578:194-200.
29. Nones J, Costa AP, Leal RB, et al. 2012. The flavonoids hesperidin and rutin promote neural crest cell survival. Cell Tissue Res 350:305-315.
30. Oh SB, Park HR, Jang YJ, et al. 2013. Neuroprotective effects of baicalein against γ-ray radiation. Br J Pharmacol 168:421-431.
31. Palazzolo G, Horvath P, Zenobi-Wong M. 2012. The flavonoid isoquercitrin promotes neurite elongation by reducing RhoA activity. PLoS One 7:e49979.
32. Paulsen BS, Souza CS, Chicaybam L, et al. 2011. Agathisflavone enhances retinoic acid-induced neurogenesis and its receptors α and β in pluripotent stem cells. Stem Cells Dev 20:1711-1721.
33. Plakas SM, Lee TC, Wolke RE. 1985. Absence of overt toxicity from feeding the flavonol, quercetin, to rainbow trout (Salmo gairdneri). Food Chem Toxicol 23:1077-1080.
34. Rice-Evans C, Spencer JPE, Schroeter H, et al. 2000. Bioavailability of flavonoids and potential bioactive forms in vivo. Drug Metab Drug Interactions 17:291-310.
35. Sajad M, Zargan J, Zargar MA, et al. 2013. Quercetin prevents protein nitration and glycolytic block of proliferation in hydrogen peroxide insulted cultured neuronal precursor cells (NPCs): implications on CNS regeneration. Neurotoxicology 36:24-33.
36. Schneider H, Schwiertz A, Collins MD, et al. 1999. Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract. Arch Microbiol 171:81-91.
37. Setchell KDR, Brown NM, Desai P, et al. 2001. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131:1362S-1375S.
38. Sierpina VS, Wollschlaeger B, Blumenthal M. 2003. Ginkgo biloba. Am Fam Phys 68:923-926.
39. Smriga M, Saito H, Nishiyama N. 1997. Ginkgo biloba facilitates synaptic plasticity in the rat perforant path: dentate gyrus projections in-vivo. Pharma Sci 3:521-523.
40. Spencer JPE. 2007. The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2:257-273.
41. Tan KH, Dobbie MS, Felix RA, et al. 2001. A comparison of the induction of immortalized endothelial cell impermeability by astrocytes. NeuroReport 12:1329-1334.
42. Trofimiuk E, Holownia A, Braszko JJ. 2011. St. John's wort may relieve negative effects of stress on spatial working memory by changing synaptic plasticity. Naunyn-Schmiedeberg's Arch Pharmacol 383:415-422.
43. Van Praag H, Lucero MJ, Yeo GW, et al. 2007. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci 27:5869-5878.
44. Vaya J, Tamir S. 2004. The relation between the chemical structure of flavonoids and their estrogen-like activities. Curr Med Chem 11:1333-1343.
45. Vining Smith J, Luo Y. 2003. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J Alzheimer's Dis 5:287-300.
46. Weng MS, Liao CH, Yu SY, et al. 2011. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. J Agric Food Chem 59:1031-1040.
47. Xu B, Li XX, He GR, et al. 2010. Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats. Eur J Pharmacol 627:99-105.
48. Xu SL, Bi CWC, Choi RCY, et al. 2013. Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor. Evidence-based Complementary Alternative Med 2013:127075.
49. Xu SL, Zhu KY, Bi CWC, et al. Flavonoids induce the expression of synaptic proteins, synaptotagmin and post-synaptic density protein-95, in cultured rat cortical neuron. Planta Med (in press).
50. Xu SL, Choi RCY, Zhu KY, et al. 2012. Isorhamnetin, a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured PC12 cells: potentiating the effect of nerve growth factor. Evidence Complementary Alternative Med 2012:278273.
51. Yao R, Zhang L, Li X, et al. 2010. Effects of epimedium flavonoids on proliferation and differentiation of neural stem cells in vitro. Neurol Res 32:736-742.
52. Yi L, Jin X, Chen CY, et al. 2011. Chemical structures of 4-oxo-flavonoids in relation to inhibition of oxidized low-density lipoprotein (LDL)-induced vascular endothelial dysfunction. Int J Mol Sci 12:5471-5489.
53. Youdim KA, Dobbie MS, Kuhnle G, et al. 2003. Interaction between flavonoids and the blood-brain barrier: In vitro studies. J Neurochem 85:180-192.
54. Youdim KA, Shukitt-Hale B, Joseph JA. 2004. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 37:1683-1693.
55. Zeng Y, Liu Y, Wu M, et al. 2012. Activation of TrkB by 7, 8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. J Alzheimer's Dis 31:765-778.
56. Zheng KYZ, Choi RCY, Cheung AWH, et al. 2011. Flavonoids from radix astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. J Agric Food Chem 59:1697-1704.
57. Zheng KYZ, Choi RCY, Guo AJY, et al. 2012. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang. J Pharma Biomed Anal 70:671-679.
58. Zhu JTT, Choi RCY, Chu GKY, et al. 2007. Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing β-amyloid-induced cell death. J Agric Food Chem 55:2438-2445.
59. Zhu JTT, Choi RCY, Xie HQ, et al. 2009. Hibifolin, a flavonol glycoside, prevents β-amyloid-induced neurotoxicity in cultured cortical neurons. Neurosci Lett 461:172-176.