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Volumn 19, Issue 3, 2010, Pages 795-811

A flavonol glycoside, isolated from roots of panax notoginseng, reduces amyloid-β-induced neurotoxicity in cultured neurons: Signaling transduction and drug development for Alzheimer's disease

Author keywords

Alzheimer's disease; Chinese medicine; Flavonol glycoside; Neuroprotection; Panax notoginseng

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM ION; FLAVONOID GLYCOSIDE; FLAVONOL; SCOPOLAMINE;

EID: 77149139480     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1293     Document Type: Article
Times cited : (62)

References (42)
  • 1
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the AD amyloid hypothesis: A genetic perspective
    • Tanzi RE, Bertram L (2005) Twenty years of the AD amyloid hypothesis: a genetic perspective. Cell 120, 545-555.
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 2
    • 0021256895 scopus 로고
    • AD: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG,WongCW(1984) AD: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120, 885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 6
    • 0037162725 scopus 로고    scopus 로고
    • Newtherapies. NewAlzheimer's treatments that may ease the mind
    • Helmuth L (2002) Newtherapies. NewAlzheimer's treatments that may ease the mind. Science 297, 1260-1262.
    • (2002) Science , vol.297 , pp. 1260-1262
    • Helmuth, L.1
  • 7
    • 0034682788 scopus 로고    scopus 로고
    • Inhibition of toxicity in the β-amyloid peptide fragment β-(25-35) using N-methylated derivatives. A general strategy to prevent amyloid formation
    • DOI 10.1074/jbc.M003554200
    • Hughes E, Burke RM, Doig AJ (2000) Inhibition of toxicity in the beta-amyloid peptide fragment beta-(25-35) using Nmethylated derivatives: a general strategy to prevent amyloid formation. J Biol Chem 275, 25109-25115. (Pubitemid 30687002)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.33 , pp. 25109-25115
    • Hughes, E.1    Burke, R.M.2    Doig, A.J.3
  • 8
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's A-beta peptide: The many roads to perdition
    • Tanzi RE, Moir RD, Wagner SL (2004) Clearance of Alzheimer's A-beta peptide: the many roads to perdition. Neuron 43, 605-608.
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 10
    • 0242668890 scopus 로고    scopus 로고
    • Estrogen-induced cell signaling in a cellular model of AD
    • Goodenough S, Schafer M, Behl C (2003) Estrogen-induced cell signaling in a cellular model of AD. J Steroid Biochem Mol Biol 84, 301-305.
    • (2003) J Steroid Biochem Mol Biol , vol.84 , pp. 301-305
    • Goodenough, S.1    Schafer, M.2    Behl, C.3
  • 11
    • 15044364801 scopus 로고    scopus 로고
    • Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage
    • Claassen H, Schunke M, Kurz B (2005) Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage. Cell Tissue Res 319, 439-445.
    • (2005) Cell Tissue Res , vol.319 , pp. 439-445
    • Claassen, H.1    Schunke, M.2    Kurz, B.3
  • 12
    • 34147181810 scopus 로고    scopus 로고
    • Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: A comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death
    • Zhu JT, Choi RCY, Chu GKY, Cheung AWH, Gao QT, Li J, Jiang ZY, Dong TTX, Tsim KWK (2007) Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. J Agric Food Chem 55, 2438-2445.
    • (2007) J Agric Food Chem , vol.55 , pp. 2438-2445
    • Zhu, J.T.1    Choi, R.C.Y.2    Chu, G.K.Y.3    Cheung, A.W.H.4    Gao, Q.T.5    Li, J.6    Jiang, Z.Y.7    Dong, T.T.X.8    Tsim, K.W.K.9
  • 13
    • 0035895957 scopus 로고    scopus 로고
    • The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons
    • Wang CN, Chi CW, Lin YL, Chen CF, Shiao YJ (2001) The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J Biol Chem 276, 5287-5295.
    • (2001) J Biol Chem , vol.276 , pp. 5287-5295
    • Wang, C.N.1    Chi, C.W.2    Lin, Y.L.3    Chen, C.F.4    Shiao, Y.J.5
  • 14
    • 0042303937 scopus 로고    scopus 로고
    • Chemical assessment of roots of Panax notoginseng in China: Regional and seasonal variations in its active constituents
    • Dong TTX, Cui XM, Song ZH, Zhao KJ, Ji ZN, Lo CK, Tsim KWK (2003) Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents. J Agric Food Chem 51, 4617-4623.
    • (2003) J Agric Food Chem , vol.51 , pp. 4617-4623
    • Dong, T.T.X.1    Cui, X.M.2    Song, Z.H.3    Zhao, K.J.4    Ji, Z.N.5    Lo, C.K.6    Tsim, K.W.K.7
  • 15
    • 0028868824 scopus 로고
    • Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus
    • Brewer GJ (1995) Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 42, 674-683.
    • (1995) J Neurosci Res , vol.42 , pp. 674-683
    • Brewer, G.J.1
  • 17
    • 0020686674 scopus 로고
    • AD: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, DeLong MR (1983) AD: a disorder of cortical cholinergic innervation. Science 219, 1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    Delong, M.R.3
  • 19
    • 63649089666 scopus 로고    scopus 로고
    • Side effects of approved antidementives
    • Mimica N, Presecki P (2009) Side effects of approved antidementives. Psychiatr Danub 21, 108-113.
    • (2009) Psychiatr Danub , vol.21 , pp. 108-113
    • Mimica, N.1    Presecki, P.2
  • 20
    • 0034923423 scopus 로고    scopus 로고
    • A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
    • Glazier MG, Bowman MA (2001) A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 161, 1161-1172.
    • (2001) Arch Intern Med , vol.161 , pp. 1161-1172
    • Glazier, M.G.1    Bowman, M.A.2
  • 21
    • 0033227489 scopus 로고    scopus 로고
    • Growth inhibition of human breast cancer cells by herbs and phytoestrogens
    • Dixon-Shanies D, Shaikh N (1999) Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep 6, 1383-1387.
    • (1999) Oncol Rep , vol.6 , pp. 1383-1387
    • Dixon-Shanies, D.1    Shaikh, N.2
  • 22
    • 0035360280 scopus 로고    scopus 로고
    • Uterine adenocarcinoma in mice treated neonatally with genistein
    • Newbold RR, Banks EP, Bullock B, JeffersonWN(2001) Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61, 4325-4328.
    • (2001) Cancer Res , vol.61 , pp. 4325-4328
    • Newbold, R.R.1    Banks, E.P.2    Bullock, B.3    Jefferson, W.N.4
  • 23
    • 0035394121 scopus 로고    scopus 로고
    • Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dosedependent manner
    • Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG (2001) Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dosedependent manner. Cancer Res 61, 5045-5050.
    • (2001) Cancer Res , vol.61 , pp. 5045-5050
    • Allred, C.D.1    Allred, K.F.2    Ju, Y.H.3    Virant, S.M.4    Helferich, W.G.5
  • 25
    • 0037328536 scopus 로고    scopus 로고
    • Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet
    • Cicero AF, Vitale G, Savino G, Arlett R (2003) Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet. Phytother Res 17, 174-178.
    • (2003) Phytother Res , vol.17 , pp. 174-178
    • Cicero, A.F.1    Vitale, G.2    Savino, G.3    Arlett, R.4
  • 27
    • 0013643698 scopus 로고
    • Chemical studies of San-Chi Panax notoginseng I: Studies on the constituents of San-Chi root hairs
    • Wei JX,Wang JF, Chang LY, Du YC (1980) Chemical studies of San-Chi Panax notoginseng I: Studies on the constituents of San-Chi root hairs. Acta Pharm Sin 15, 359-364.
    • (1980) Acta Pharm Sin , vol.15 , pp. 359-364
    • Wei, J.X.1    Wang, J.F.2    Chang, L.Y.3    Du, Y.C.4
  • 28
    • 3042778521 scopus 로고    scopus 로고
    • Effect of Radix Notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome
    • Wang J, Xu J, Zhong JB (2004) Effect of Radix Notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 24, 312-316.
    • (2004) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.24 , pp. 312-316
    • Wang, J.1    Xu, J.2    Zhong, J.B.3
  • 29
    • 0020848503 scopus 로고
    • Hemodynamic effects of San Chi (Panax notoginseng) root, leaf, flower and saponins on anesthetized dogs
    • Chen ZH,Wang DC, Li HL,Wei JX,Wang JF, Du YC (1983) Hemodynamic effects of San Chi (Panax notoginseng) root, leaf, flower and saponins on anesthetized dogs. Acta Pharm Sin 18, 818-822.
    • (1983) Acta Pharm Sin , vol.18 , pp. 818-822
    • Chen Zhwang, D.C.1    Li Hlwei Jxwang, J.F.2    Du, Y.C.3
  • 30
    • 0001055123 scopus 로고
    • Identification of 3-O-[2-O-(β-D-Xylopyranosyl)-β-D- Galactopyranosyl] flavonoids in horseradish leaves acting as feeding stimulants for a flea beetle
    • Larsen LM, Nielsen JK, Sorensen H (1982) Identification of 3-O-[2-O-(β-D-Xylopyranosyl)-β-D-Galactopyranosyl] flavonoids in horseradish leaves acting as feeding stimulants for a flea beetle. Phytochemistry 21, 1029-1033.
    • (1982) Phytochemistry , vol.21 , pp. 1029-1033
    • Larsen, L.M.1    Nielsen, J.K.2    Sorensen, H.3
  • 32
    • 33947319498 scopus 로고    scopus 로고
    • Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogendependent pathway
    • Wang Z, Zhang X, Wang H, Qi L, Lou Y (2007) Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogendependent pathway. Neuroscience 145, 911-922.
    • (2007) Neuroscience , vol.145 , pp. 911-922
    • Wang, Z.1    Zhang, X.2    Wang, H.3    Qi, L.4    Lou, Y.5
  • 33
    • 0035919828 scopus 로고    scopus 로고
    • Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity
    • Lebeau A, Esclaire F, Rostene W, Pelaprat D (2001) Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. Neuroreport 12, 2199-2202.
    • (2001) Neuroreport , vol.12 , pp. 2199-2202
    • Lebeau, A.1    Esclaire, F.2    Rostene, W.3    Pelaprat, D.4
  • 34
    • 1642424296 scopus 로고    scopus 로고
    • Protection against hydrogen peroxideinduced cytotoxicity in PC12 cells by scutellarin
    • Hong H, LiuGQ(2004) Protection against hydrogen peroxideinduced cytotoxicity in PC12 cells by scutellarin. Life Sci 74, 2959-2973.
    • (2004) Life Sci , vol.74 , pp. 2959-2973
    • Hong, H.1    Liu, G.Q.2
  • 35
    • 73349094325 scopus 로고    scopus 로고
    • Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: A drug against postmenopausal symptoms and Alzheimer's disease
    • Zhu JT, Choi RC, Li J, Xie HQ, BiCW, Cheung AW, Dong TT, Jiang ZY, Chen JJ, Tsim KWK (2009) Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: A drug against postmenopausal symptoms and Alzheimer's disease. Planta Med 75, 1489-1493.
    • (2009) Planta Med , vol.75 , pp. 1489-1493
    • Zhu, J.T.1    Choi, R.C.2    Li, J.3    Xie, H.Q.4    Bi, C.W.5    Cheung, A.W.6    Dong, T.T.7    Jiang, Z.Y.8    Chen, J.J.9    Tsim, K.W.K.10
  • 36
    • 0037954417 scopus 로고    scopus 로고
    • Neuroprotective role of learning in dementia: A biological explanation
    • Addae JI, Youssef FF, Stone TW (2003) Neuroprotective role of learning in dementia: a biological explanation. J Alzheimers Dis 5, 91-104.
    • (2003) J Alzheimers Dis , vol.5 , pp. 91-104
    • Addae, J.I.1    Youssef, F.F.2    Stone, T.W.3
  • 38
    • 7444253369 scopus 로고    scopus 로고
    • Flavonoids and the brain: Interactions at the blood-brain barrier and their physiological effects on the central nervous system
    • Youdim KA, Shukitt-Hale B, Joseph JA (2004) Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 37, 1683-1693.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1683-1693
    • Youdim, K.A.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 40
    • 63649135792 scopus 로고    scopus 로고
    • Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection
    • Lebesgue D, Chevaleyre V, Zukin RS, EtgenAM(2009) Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 74, 555-561.
    • (2009) Steroids , vol.74 , pp. 555-561
    • Lebesgue, D.1    Chevaleyre, V.2    Zukin, R.S.3    Etgen, A.M.4
  • 42
    • 20444488688 scopus 로고    scopus 로고
    • From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
    • Amantea D, Russo R, Bagetta G, Corasaniti MT (2005) From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52, 119-132.
    • (2005) Pharmacol Res , vol.52 , pp. 119-132
    • Amantea, D.1    Russo, R.2    Bagetta, G.3    Corasaniti, M.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.