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Volumn 350, Issue 2, 2012, Pages 305-315

The flavonoids hesperidin and rutin promote neural crest cell survival

Author keywords

Cell survival and differentiation; ERK and PI3 kinase pathway; Flavonoids; Neural crest

Indexed keywords

CHEMICAL COMPOUND; FLAVONOID; HESPERIDIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL; QUERCETIN; RUTOSIDE;

EID: 84871244544     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-012-1472-y     Document Type: Article
Times cited : (36)

References (57)
  • 1
    • 0027267315 scopus 로고
    • Flavonoids from koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors
    • Abou-Shoer M, Ma GE, Li XH, Koonchanok NM, Geahlen RL, Chang CJ (1993) Flavonoids from koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. J Nat Prod 56:967-969
    • (1993) J Nat Prod , vol.56 , pp. 967-969
    • Abou-Shoer, M.1    Ma, G.E.2    Li, X.H.3    Koonchanok, N.M.4    Geahlen, R.L.5    Chang, C.J.6
  • 2
    • 0030842112 scopus 로고    scopus 로고
    • Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase c inhibition
    • Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, Payrastre B (1997) Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53:1649-1657
    • (1997) Biochem Pharmacol , vol.53 , pp. 1649-1657
    • Agullo, G.1    Gamet-Payrastre, L.2    Manenti, S.3    Viala, C.4    Rémésy, C.5    Chap, H.6    Payrastre, B.7
  • 3
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: Nomenclature, occurrence and intake
    • Beecher GR (2003) Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133:3248-3254
    • (2003) J Nutr , vol.133 , pp. 3248-3254
    • Beecher, G.R.1
  • 5
    • 38049152844 scopus 로고    scopus 로고
    • Sonic hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials
    • Calloni GW, Glavieux-Pardanaud C, Le Douarin NM, Dupin E (2007) Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials. Proc Natl Acad Sci USA 104:19879-19884
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19879-19884
    • Calloni, G.W.1    Glavieux-Pardanaud, C.2    Le Douarin, N.M.3    Dupin, E.4
  • 6
    • 67049154039 scopus 로고    scopus 로고
    • High frequency of cephalic neural crest cells shows coexistence of neurogenic, melanogenic, and osteogenic differentiation capacities
    • Calloni GW, Le Douarin NM, Dupin E (2009) High frequency of cephalic neural crest cells shows coexistence of neurogenic, melanogenic, and osteogenic differentiation capacities. Proc Natl Acad Sci USA 106:8947-8952
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8947-8952
    • Calloni, G.W.1    Le Douarin, N.M.2    Dupin, E.3
  • 7
    • 0029789856 scopus 로고    scopus 로고
    • Free radicals and ethanol-induced cytotoxicity in neural crest cells
    • Chen SY, Sulik KK (1996) Free radicals and ethanol-induced cytotoxicity in neural crest cells. Alcohol Clin Exp Res 20:1071-1076
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 1071-1076
    • Chen, S.Y.1    Sulik, K.K.2
  • 8
    • 0033932005 scopus 로고    scopus 로고
    • Iron-mediated free radical injury in ethanolexposed mouse nc cells
    • Chen SY, Sulik KK (2000) Iron-mediated free radical injury in ethanolexposed mouse NC cells. J Pharmacol Exp Ther 294:134-140
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 134-140
    • Chen, S.Y.1    Sulik, K.K.2
  • 9
    • 0034573074 scopus 로고    scopus 로고
    • Activation of antioxidant response element (are), mitogen-activated protein kinases (mapks) and caspases by major green tea polyphenol components during cell survival and death
    • Chen C, Yu R, Owuor ED, Kong AN (2000) Activation of antioxidant response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 6:605-612
    • (2000) Arch Pharm Res , vol.6 , pp. 605-612
    • Chen, C.1    Yu, R.2    Owuor, E.D.3    Kong, A.N.4
  • 12
    • 74949118234 scopus 로고    scopus 로고
    • The cephalic neural crest of amniote vertebrates is composed of a large majority of precursors endowed with neural, melanocytic, chondrogenic and osteogenic potentialities
    • Dupin E, Calloni GW, Le Douarin NM (2010) The cephalic neural crest of amniote vertebrates is composed of a large majority of precursors endowed with neural, melanocytic, chondrogenic and osteogenic potentialities. Cell Cycle 9:238-249
    • (2010) Cell Cycle , vol.9 , pp. 238-249
    • Dupin, E.1    Calloni, G.W.2    Le Douarin, N.M.3
  • 14
    • 79960067857 scopus 로고    scopus 로고
    • Calcium-mediated repression of ß-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome
    • Flentke GR, Garic A, Amberger E, Hernandez M, Smith SM (2011) Calcium-mediated repression of ß-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome. Birth Defects Res A Clin Mol Teratol 7:591-602
    • (2011) Birth Defects Res A Clin Mol Teratol , vol.7 , pp. 591-602
    • Flentke, G.R.1    Garic, A.2    Amberger, E.3    Hernandez, M.4    Smith, S.M.5
  • 15
    • 79960068816 scopus 로고    scopus 로고
    • Camkii activation is a novel effector of alcohol's neurotoxicity in neural crest stem/progenitor cells
    • Garic A, Flentke GR, Amberger E, Hernandez M, Smith SM (2011) CaMKII activation is a novel effector of alcohol's neurotoxicity in neural crest stem/progenitor cells. J Neurochem 118:646-657
    • (2011) J Neurochem , vol.118 , pp. 646-657
    • Garic, A.1    Flentke, G.R.2    Amberger, E.3    Hernandez, M.4    Smith, S.M.5
  • 16
    • 33644770313 scopus 로고    scopus 로고
    • Structural constraints for alcohol-stimulated ca2+ release in neural crest, and dual agonist/antagonist properties of n-octanol
    • Garic-Stankovic A, Hernandez M, Flentke GR, Smith SM (2006) Structural constraints for alcohol-stimulated Ca2+ release in neural crest, and dual agonist/antagonist properties of n-octanol. Alcohol Clin Exp Res 30:552-559
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 552-559
    • Garic-Stankovic, A.1    Hernandez, M.2    Flentke, G.R.3    Smith, S.M.4
  • 17
    • 0023897154 scopus 로고
    • Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases
    • Hagiwara M, Inoue S, Tanaka T, Nunoki K, Ito M, Hidaka H (1988) Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem Pharmacol 37:2987-2992
    • (1988) Biochem Pharmacol , vol.37 , pp. 2987-2992
    • Hagiwara, M.1    Inoue, S.2    Tanaka, T.3    Nunoki, K.4    Ito, M.5    Hidaka, H.6
  • 18
    • 0020626421 scopus 로고
    • Flavonoids a class of natural products of high pharmacological potency
    • Havesteen B (1983) Flavonoids a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-1148
    • (1983) Biochem Pharm , vol.32 , pp. 1141-1148
    • Havesteen, B.1
  • 20
    • 33645094927 scopus 로고    scopus 로고
    • Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate
    • Khan N, Afaq F, Saleem M, Ahmad N, Mukhtar H (2006) Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res 66:2500-2555
    • (2006) Cancer Res , vol.66 , pp. 2500-2555
    • Khan, N.1    Afaq, F.2    Saleem, M.3    Ahmad, N.4    Mukhtar, H.5
  • 21
    • 0026665226 scopus 로고
    • Experimental fetal alcohol syndrome: Proposed pathogenic basis for a variety of associated facial and brain anomalies
    • Kotch LE, Sulik KK (1992) Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated facial and brain anomalies. Am J Med Genet 44:168-176
    • (1992) Am J Med Genet , vol.44 , pp. 168-176
    • Kotch, L.E.1    Sulik, K.K.2
  • 22
    • 0028846081 scopus 로고
    • Ethanol-induced teratogenesis: Free radical damage as a possible mechanism
    • Kotch LE, Chen AY, Sulik KK (1995) Ethanol-induced teratogenesis: free radical damage as a possible mechanism. Teratology 52:128-136
    • (1995) Teratology , vol.52 , pp. 128-136
    • Kotch, L.E.1    Chen, A.Y.2    Sulik, K.K.3
  • 23
    • 0033230132 scopus 로고    scopus 로고
    • Extraction of rutin from buckwheat (fagopyrum esculentum moench) seeds and determination by capillary electrophoresis
    • Kreft S, Knapp M, Kreft I (1999) Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis. J Agric Food Chem 47:4649-4652
    • (1999) J Agric Food Chem , vol.47 , pp. 4649-4652
    • Kreft, S.1    Knapp, M.2    Kreft, I.3
  • 26
    • 35148893111 scopus 로고    scopus 로고
    • Role of the neural crest in face and brain development
    • Le Douarin NM, Brito JM, Creuzet S (2007) Role of the neural crest in face and brain development. Brain Res Rev 55:237-247
    • (2007) Brain Res Rev , vol.55 , pp. 237-247
    • Le Douarin, N.M.1    Brito, J.M.2    Creuzet, S.3
  • 28
    • 0034851553 scopus 로고    scopus 로고
    • Green tea polyphenols (-)-epigallocatechin-3-gallate prevents n-methyl-4-phenyl-1, 2,3 6-tetrahydropyridine-induced dopaminergic neurodegeneration
    • Levites Y, Weinreb O, Maor GJ, Youdim MB, Mandel S (2001) Green tea polyphenols (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78:1073-1082
    • (2001) J Neurochem , vol.78 , pp. 1073-1082
    • Levites, Y.1    Weinreb, O.2    Maor, G.J.3    Youdim, M.B.4    Mandel, S.5
  • 29
    • 0037163110 scopus 로고    scopus 로고
    • Involvement of protein kinase c activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action
    • Levites Y, Amit T, Youdim MB, Mandel S (2002) Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate Neuroprotective action. J Biol Chem 277:30574-30580
    • (2002) J Biol Chem , vol.277 , pp. 30574-30580
    • Levites, Y.1    Amit, T.2    Youdim, M.B.3    Mandel, S.4
  • 30
    • 0031128057 scopus 로고    scopus 로고
    • Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion
    • Mallo M (1997) Retinoic Acid Disturbs Mouse Middle Ear Development in a Stage-Dependent Fashion. Dev Biol 184:175-186
    • (1997) Dev Biol , vol.184 , pp. 175-186
    • Mallo, M.1
  • 31
    • 0036674897 scopus 로고    scopus 로고
    • Gaba(a)-receptor ligands of flavonoid structure
    • Marder M, Paladini AC (2002) GABA(A)-receptor ligands of flavonoid structure. Curr Top Med Chem 8:853-867
    • (2002) Curr Top Med Chem , vol.8 , pp. 853-867
    • Marder, M.1    Paladini, A.C.2
  • 32
    • 0027233623 scopus 로고
    • Novel markers of melanocyte differentiation in the avian embryo
    • Nataf V, Mercier P, Ziller C, Le Douarin NM (1993) Novel markers of melanocyte differentiation in the avian embryo. Exp Cell Res 207:171-182
    • (1993) Exp Cell Res , vol.207 , pp. 171-182
    • Nataf, V.1    Mercier, P.2    Ziller, C.3    Le Douarin, N.M.4
  • 33
    • 77953232427 scopus 로고    scopus 로고
    • Flavonoids astrocytes crosstalking: Implications for brain development and pathology
    • Nones J, Stipursky J, Costa LC, Gomes FCA (2010) Flavonoids and Astrocytes Crosstalking: Implications for Brain Development and Pathology. Neurochem Res 35:955-966
    • (2010) Neurochem Res , vol.35 , pp. 955-966
    • Nones, J.1    Stipursky, J.2    Costa, L.C.3    Gomes, F.C.A.4
  • 34
    • 80555126828 scopus 로고    scopus 로고
    • Hesperidin, a flavone glycoside, as mediator of neuronal survival
    • Nones J, Spohr TCL, Gomes FCA (2011) Hesperidin, a flavone glycoside, as mediator of neuronal survival. Neurochem Res 36:1776-1784
    • (2011) Neurochem Res , vol.36 , pp. 1776-1784
    • Nones, J.1    Spohr, T.C.L.2    Gomes, F.C.A.3
  • 35
    • 84860503525 scopus 로고    scopus 로고
    • Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro: Indirect action through astrocytes
    • Nones J, Spohr TC, Gomes FC (2012) Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro: indirect action through astrocytes. Int J Dev Neurosci 30:303-313
    • (2012) Int J Dev Neurosci , vol.30 , pp. 303-313
    • Nones, J.1    Spohr, T.C.2    Gomes, F.C.3
  • 36
    • 0036708902 scopus 로고    scopus 로고
    • Antioxidants and oxidants regulated signal transduction pathways
    • Owuor ED, Kong AN (2002) Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 64:765-770
    • (2002) Biochem Pharmacol , vol.64 , pp. 765-770
    • Owuor, E.D.1    Kong, A.N.2
  • 39
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20:933-956
    • (1996) Free Radic Biol Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 40
    • 0033179287 scopus 로고    scopus 로고
    • Phytoestrogen kaempferol (3,4-,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity
    • Roth A, Schaffner W, Hertel C (1999) Phytoestrogen kaempferol (3,4-,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. J Neurosci Res 57:399-404
    • (1999) J Neurosci Res , vol.57 , pp. 399-404
    • Roth, A.1    Schaffner, W.2    Hertel, C.3
  • 41
    • 0034648063 scopus 로고    scopus 로고
    • Neuroprotection by mapk/erk kinase inhibition with u0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
    • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S (2000) Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288:163-166
    • (2000) Neurosci Lett , vol.288 , pp. 163-166
    • Satoh, T.1    Nakatsuka, D.2    Watanabe, Y.3    Nagata, I.4    Kikuchi, H.5    Namura, S.6
  • 44
    • 0041816456 scopus 로고    scopus 로고
    • Modulation of prosurvival akt/protein kinase b and erk1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    • Spencer JPE, Rice-Evans C, Williams RJ (2003) Modulation of prosurvival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 278:34783-34793
    • (2003) J Biol Chem , vol.278 , pp. 34783-34793
    • Spencer, J.P.E.1    Rice-Evans, C.2    Williams, R.J.3
  • 45
    • 73949094232 scopus 로고    scopus 로고
    • Effects of the flavonoid casticin from brazilian cróton betulaster in cerebral cortical progenitors in vitro: Direct and indirect action through astrocytes
    • Spohr TCL, Stipursky J, Sasaki AC, Barbosa PR, Martins V, Benjamim CF, Roque NF, Costa SL, Gomes FCA (2010) Effects of the flavonoid casticin from Brazilian Cróton betulaster in cerebral cortical progenitors in vitro: Direct and indirect action through astrocytes. J Neurosci Res 15:530-541
    • (2010) J Neurosci Res , vol.15 , pp. 530-541
    • Spohr, T.C.L.1    Stipursky, J.2    Sasaki, A.C.3    Barbosa, P.R.4    Martins, V.5    Benjamim, C.F.6    Roque, N.F.7    Costa, S.L.8    Gomes, F.C.A.9
  • 46
    • 0029043215 scopus 로고
    • Thyroid hormone and conditioned medium effects on astroglial cells from hypothyroid and normal rat brain: Factor secretion, cell differentiation, and proliferation
    • Trentin A, Rosenthal D, Maura Neto V (1995) Thyroid hormone and conditioned medium effects on astroglial cells from hypothyroid and normal rat brain: factor secretion, cell differentiation, and proliferation. J Neurosci Res 41:409-417
    • (1995) J Neurosci Res , vol.41 , pp. 409-417
    • Trentin, A.1    Rosenthal, D.2    Maura Neto, V.3
  • 47
    • 1842585600 scopus 로고    scopus 로고
    • Self-renewal capacity is a widespread property of various types of nc precursor cells
    • Trentin A, Glavieux-Pardanaud C, Le Douarin NM, Dupin E (2004) Self-renewal capacity is a widespread property of various types of NC precursor cells. Proc Natl Acad Sci USA. doi:101:4495-4500
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4495-4500
    • Trentin, A.1    Glavieux-Pardanaud, C.2    Le Douarin, N.M.3    Dupin, E.4
  • 48
    • 35448949428 scopus 로고    scopus 로고
    • Activation of prosurvival akt and erk1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
    • Vauzour D, Vafeiadou K, Rice-Evans C, Williams RJ, Spencer JP (2007) Activation of prosurvival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. J Neurochem. doi:103:1355-1367
    • (2007) J Neurochem. doi , vol.103 , pp. 1355-1367
    • Vauzour, D.1    Vafeiadou, K.2    Rice-Evans, C.3    Williams, R.J.4    Spencer, J.P.5
  • 49
    • 0033895179 scopus 로고    scopus 로고
    • 6, 3'-Dibromoflavone and 6-nitro-3'-bromoflavone: New additions to the 6, 3'-disubstituted flavone family of high-affinityligands of the brain benzodiazepine binding site with agonistic properties
    • Viola H, Marder M, Wasowski C, Giorgi O, Paladini AC, Medina JH (2000) 6, 3'-Dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6, 3'-disubstituted flavone family of high-affinityligands of the brain benzodiazepine binding site with agonistic properties. Biochem Biophys Res Commun 273:694-698
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 694-698
    • Viola, H.1    Marder, M.2    Wasowski, C.3    Giorgi, O.4    Paladini, A.C.5    Medina, J.H.6
  • 50
    • 0035895957 scopus 로고    scopus 로고
    • The neuroprotective effects of phytoestrogens on amyloid beta proteininduced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons
    • Wang CN, Chi CW, Lin YL, Chen CF, Shiao YJ (2001) The neuroprotective effects of phytoestrogens on amyloid beta proteininduced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J Biol Chem 276:5287-5295
    • (2001) J Biol Chem , vol.276 , pp. 5287-5295
    • Wang, C.N.1    Chi, C.W.2    Lin, Y.L.3    Chen, C.F.4    Shiao, Y.J.5
  • 51
    • 77957949839 scopus 로고    scopus 로고
    • Astaxanthin upregulates heme oxygenase-1 expression through erk1/2 pathway and its protective effect against beta-amyloidinduced cytotoxicity in sh-sy5y cells
    • Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ (2010) Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloidinduced cytotoxicity in SH-SY5Y cells. Brain Res 1360:159-167
    • (2010) Brain Res , vol.1360 , pp. 159-167
    • Wang, H.Q.1    Sun, X.B.2    Xu, Y.X.3    Zhao, H.4    Zhu, Q.Y.5    Zhu, C.Q.6
  • 52
    • 4444226105 scopus 로고    scopus 로고
    • Neurological mechanisms of green tea polyphenols in alzheimer's and parkinson's diseases
    • Weinreb O, Mandel S, Amit T, Youdim MB (2004) Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem 15:506-516
    • (2004) J Nutr Biochem , vol.15 , pp. 506-516
    • Weinreb, O.1    Mandel, S.2    Amit, T.3    Youdim, M.B.4
  • 53
    • 71549148981 scopus 로고    scopus 로고
    • Altered gene expression in neural crest cells exposed to ethanol in vitro
    • Wentzel P, Eriksson UJ (2009) Altered gene expression in neural crest cells exposed to ethanol in vitro. Brain Res 1305:50-60
    • (2009) Brain Res , vol.1305 , pp. 50-60
    • Wentzel, P.1    Eriksson, U.J.2
  • 54
    • 0028630709 scopus 로고
    • Fetal alcohol syndrome -The vulnerability of the developing brain and possible mechanisms of damage
    • West JR, Chen WJA, Pantazis NJ (1994) Fetal alcohol syndrome -the vulnerability of the developing brain and possible mechanisms of damage. Metab Brain Dis 9:291-322
    • (1994) Metab Brain Dis , vol.9 , pp. 291-322
    • West, J.R.1    Chen, W.J.A.2    Pantazis, N.J.3
  • 56
    • 77952289451 scopus 로고    scopus 로고
    • Induction of the nrf2-driven antioxidant response by tert- butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells
    • Yan D, Dong J, Sulik KK, Chen SY (2010) Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. Biochem Pharmacol 80:144-149
    • (2010) Biochem Pharmacol , vol.80 , pp. 144-149
    • Yan, D.1    Dong, J.2    Sulik, K.K.3    Chen, S.Y.4
  • 57
    • 77649273007 scopus 로고    scopus 로고
    • Folic acid and soybean isoflavone combined supplementation protects the postneural tube closure defects of rodents induced by cyclophosphamide in vivo and in vitro
    • Zaho H, Liang J, Li X, Yu H, Li X, Xiao R (2010) Folic acid and soybean isoflavone combined supplementation protects the postneural tube closure defects of rodents induced by cyclophosphamide in vivo and in vitro. Neuro Toxicol 31:180-187
    • (2010) Neuro Toxicol , vol.31 , pp. 180-187
    • Zaho, H.1    Liang, J.2    Li, X.3    Yu, H.4    Li, X.5    Xiao, R.6


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