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Volumn 68, Issue 1, 2014, Pages 96-107

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: A workshop summary

Author keywords

Environmental chemicals; Immunotoxicity; Testing

Indexed keywords

ENVIRONMENTAL CHEMICAL;

EID: 84890284139     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.11.012     Document Type: Article
Times cited : (59)

References (77)
  • 1
    • 79956348442 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010
    • Adler S., et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch. Toxicol. 2011, 85:367-485.
    • (2011) Arch. Toxicol. , vol.85 , pp. 367-485
    • Adler, S.1
  • 2
    • 77956176101 scopus 로고    scopus 로고
    • Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program
    • Aeby P., et al. Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol. In Vitro 2010, 24:1465-1473.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 1465-1473
    • Aeby, P.1
  • 3
    • 77955906570 scopus 로고    scopus 로고
    • The vision of toxicity testing in the 21st century: moving from discussion to action
    • Andersen M.E., Krewski D. The vision of toxicity testing in the 21st century: moving from discussion to action. Toxicol. Sci. 2010, 117:17-24.
    • (2010) Toxicol. Sci. , vol.117 , pp. 17-24
    • Andersen, M.E.1    Krewski, D.2
  • 4
    • 34247135041 scopus 로고    scopus 로고
    • Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59
    • Basketter D., et al. Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59. Altern. Lab. Anim. 2007, 35:137-154.
    • (2007) Altern. Lab. Anim. , vol.35 , pp. 137-154
    • Basketter, D.1
  • 5
    • 73649133977 scopus 로고    scopus 로고
    • The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides
    • Billington R., et al. The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides. Crit. Rev. Toxicol. 2010, 40:35-49.
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 35-49
    • Billington, R.1
  • 6
    • 78650071290 scopus 로고    scopus 로고
    • Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia
    • Bugelski P.J., et al. Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia. Int. J. Toxicol. 2010, 29:435-466.
    • (2010) Int. J. Toxicol. , vol.29 , pp. 435-466
    • Bugelski, P.J.1
  • 7
    • 0035159020 scopus 로고    scopus 로고
    • Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender
    • Bunn T.L., et al. Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender. Toxicol. Sci. 2001, 64:57-66.
    • (2001) Toxicol. Sci. , vol.64 , pp. 57-66
    • Bunn, T.L.1
  • 8
    • 42049095775 scopus 로고    scopus 로고
    • What's so special about the developing immune system?
    • Burns-Naas L.A., et al. What's so special about the developing immune system?. Int. J. Toxicol. 2008, 27:223-254.
    • (2008) Int. J. Toxicol. , vol.27 , pp. 223-254
    • Burns-Naas, L.A.1
  • 9
    • 20144389652 scopus 로고    scopus 로고
    • Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
    • Casati S., et al. Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. Altern. Lab. Anim. 2005, 33:47-62.
    • (2005) Altern. Lab. Anim. , vol.33 , pp. 47-62
    • Casati, S.1
  • 10
    • 85033506124 scopus 로고    scopus 로고
    • The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function
    • Chapin R.E., et al. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam. Appl. Toxicol. 1997, 40:138-157.
    • (1997) Fundam. Appl. Toxicol. , vol.40 , pp. 138-157
    • Chapin, R.E.1
  • 11
    • 33644851142 scopus 로고    scopus 로고
    • A tiered approach to life stages testing for agricultural chemical safety assessment
    • Cooper R.L., et al. A tiered approach to life stages testing for agricultural chemical safety assessment. Crit. Rev. Toxicol. 2006, 36:69-98.
    • (2006) Crit. Rev. Toxicol. , vol.36 , pp. 69-98
    • Cooper, R.L.1
  • 12
    • 70449579357 scopus 로고    scopus 로고
    • Immunotoxicology: opportunities for non-animal test development
    • Corsini E., Roggen E.L. Immunotoxicology: opportunities for non-animal test development. Altern. Lab. Anim. 2009, 37:387-397.
    • (2009) Altern. Lab. Anim. , vol.37 , pp. 387-397
    • Corsini, E.1    Roggen, E.L.2
  • 13
    • 73649131586 scopus 로고    scopus 로고
    • A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals
    • Dellarco V.L., et al. A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for conventional pesticide chemicals. Crit. Rev. Toxicol. 2010, 40:16-23.
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 16-23
    • Dellarco, V.L.1
  • 14
    • 84858781810 scopus 로고    scopus 로고
    • Current status of developmental immunotoxicity: early-life patterns and testing
    • DeWitt J.C., et al. Current status of developmental immunotoxicity: early-life patterns and testing. Toxicol. Pathol. 2012, 40:230-236.
    • (2012) Toxicol. Pathol. , vol.40 , pp. 230-236
    • DeWitt, J.C.1
  • 15
    • 0033939623 scopus 로고    scopus 로고
    • Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary
    • Dietert R.R., et al. Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environ. Health Perspect. 2000, 108(Suppl 3):483-490.
    • (2000) Environ. Health Perspect. , vol.108 , Issue.SUPPL 3 , pp. 483-490
    • Dietert, R.R.1
  • 16
    • 63649098913 scopus 로고    scopus 로고
    • Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound
    • dos Santos G.G., et al. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol. 2009, 236:372-382.
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 372-382
    • dos Santos, G.G.1
  • 17
    • 84865536434 scopus 로고    scopus 로고
    • Feasibility of the extended one-generation reproductive toxicity study (OECD 443)
    • Fegert I., et al. Feasibility of the extended one-generation reproductive toxicity study (OECD 443). Reprod. Toxicol. 2012, 34:331-339.
    • (2012) Reprod. Toxicol. , vol.34 , pp. 331-339
    • Fegert, I.1
  • 18
    • 82655173956 scopus 로고    scopus 로고
    • Specific antibody responses of primary cells from different cell sources are able to predict immunotoxicity in vitro
    • Fischer A., et al. Specific antibody responses of primary cells from different cell sources are able to predict immunotoxicity in vitro. Toxicol. In Vitro 2011, 25:1966-1973.
    • (2011) Toxicol. In Vitro , vol.25 , pp. 1966-1973
    • Fischer, A.1
  • 19
    • 78649260280 scopus 로고    scopus 로고
    • Present and future of in vitro immunotoxicology in drug development
    • Galbiati V., et al. Present and future of in vitro immunotoxicology in drug development. J. Immunotoxicol. 2010, 7:255-267.
    • (2010) J. Immunotoxicol. , vol.7 , pp. 255-267
    • Galbiati, V.1
  • 20
    • 84890267168 scopus 로고    scopus 로고
    • in submission. Retrospective evaluation of the impact of functional immunotoxicity testing on pesticide hazard identification and risk assessment.
    • Gehen, S. C., et al., in submission. Retrospective evaluation of the impact of functional immunotoxicity testing on pesticide hazard identification and risk assessment.
    • Gehen, S.C.1
  • 21
    • 0033019907 scopus 로고    scopus 로고
    • Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Gehrs B.C., Smialowicz R.J. Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 1999, 134:79-88.
    • (1999) Toxicology , vol.134 , pp. 79-88
    • Gehrs, B.C.1    Smialowicz, R.J.2
  • 22
    • 28244452562 scopus 로고    scopus 로고
    • The use of in vitro systems for evaluating immunotoxicity: the report and recommendations of an ECVAM workshop
    • Gennari A., et al. The use of in vitro systems for evaluating immunotoxicity: the report and recommendations of an ECVAM workshop. J. Immunotoxicol. 2005, 2:61-83.
    • (2005) J. Immunotoxicol. , vol.2 , pp. 61-83
    • Gennari, A.1
  • 23
    • 45549085219 scopus 로고    scopus 로고
    • Chemical reactivity measurement and the predicitve identification of skin sensitisers. The report and recommendations of ECVAM workshop 64
    • Gerberick F., et al. Chemical reactivity measurement and the predicitve identification of skin sensitisers. The report and recommendations of ECVAM workshop 64. Altern. Lab. Anim. 2008, 36:215-242.
    • (2008) Altern. Lab. Anim. , vol.36 , pp. 215-242
    • Gerberick, F.1
  • 24
    • 33645705647 scopus 로고    scopus 로고
    • Immune function tests for hazard identification: a paradigm shift in drug development
    • Gore E.R. Immune function tests for hazard identification: a paradigm shift in drug development. Basic Clin. Pharmacol. Toxicol. 2006, 98:331-335.
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.98 , pp. 331-335
    • Gore, E.R.1
  • 25
    • 77950859861 scopus 로고    scopus 로고
    • The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing
    • Haglund C., et al. The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing. Toxicol. Lett. 2010, 194:102-107.
    • (2010) Toxicol. Lett. , vol.194 , pp. 102-107
    • Haglund, C.1
  • 26
    • 0036760267 scopus 로고    scopus 로고
    • Developmental immunotoxicology and risk assessment: a workshop summary
    • Holsapple M.P. Developmental immunotoxicology and risk assessment: a workshop summary. Hum. Exp. Toxicol. 2002, 21:473-478.
    • (2002) Hum. Exp. Toxicol. , vol.21 , pp. 473-478
    • Holsapple, M.P.1
  • 27
    • 0037392991 scopus 로고    scopus 로고
    • Developmental immunotoxicity testing: a review
    • Holsapple M.P. Developmental immunotoxicity testing: a review. Toxicology 2003, 185:193-203.
    • (2003) Toxicology , vol.185 , pp. 193-203
    • Holsapple, M.P.1
  • 28
    • 12344331457 scopus 로고    scopus 로고
    • A proposed testing framework for developmental immunotoxicology (DIT)
    • Holsapple M.P., et al. A proposed testing framework for developmental immunotoxicology (DIT). Toxicol. Sci. 2005, 83:18-24.
    • (2005) Toxicol. Sci. , vol.83 , pp. 18-24
    • Holsapple, M.P.1
  • 29
    • 4143049254 scopus 로고    scopus 로고
    • Symposium summary: children's health risk-what's so special about the developing immune system?
    • Holsapple M.P., et al. Symposium summary: children's health risk-what's so special about the developing immune system?. Toxicol. Appl. Pharmacol. 2004, 199:61-70.
    • (2004) Toxicol. Appl. Pharmacol. , vol.199 , pp. 61-70
    • Holsapple, M.P.1
  • 30
    • 84992825730 scopus 로고    scopus 로고
    • Development of a framework for developmental immunotoxicity (DIT) testing
    • CRC Press, Boca Raton, R. Luebke (Ed.)
    • Holsapple M.P., et al. Development of a framework for developmental immunotoxicity (DIT) testing. Immunotoxicology and Immunopharmacology 2007, 347-361. CRC Press, Boca Raton. R. Luebke (Ed.).
    • (2007) Immunotoxicology and Immunopharmacology , pp. 347-361
    • Holsapple, M.P.1
  • 31
    • 0033920994 scopus 로고    scopus 로고
    • An overview of in vitro/ex vivo assays for preclinical evaluation of immunomodulation
    • House R.V. An overview of in vitro/ex vivo assays for preclinical evaluation of immunomodulation. Hum. Exp. Toxicol. 2000, 19:246-250.
    • (2000) Hum. Exp. Toxicol. , vol.19 , pp. 246-250
    • House, R.V.1
  • 32
    • 84890268603 scopus 로고    scopus 로고
    • IARC, Inorganic and Organic Lead Compounds. vol. 87. World Health Organization International Agency for Research on Cancer, Lyon, France
    • IARC, 2006. Inorganic and Organic Lead Compounds. vol. 87. World Health Organization International Agency for Research on Cancer, Lyon, France.
    • (2006)
  • 34
    • 0032489063 scopus 로고    scopus 로고
    • Report of validation study of assessment of direct immunotoxicity in the rat
    • ICICIS Group Investigators
    • Report of validation study of assessment of direct immunotoxicity in the rat. Toxicology 1998, 125:183-201. ICICIS Group Investigators.
    • (1998) Toxicology , vol.125 , pp. 183-201
  • 35
    • 0024356617 scopus 로고
    • A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study
    • Kimber I., Weisenberger C. A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study. Arch. Toxicol. 1989, 63:274-282.
    • (1989) Arch. Toxicol. , vol.63 , pp. 274-282
    • Kimber, I.1    Weisenberger, C.2
  • 36
    • 58149178558 scopus 로고    scopus 로고
    • Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro
    • Koeper L.M., Vohr H.W. Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro. Food Chem. Toxicol. 2009, 47:110-118.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 110-118
    • Koeper, L.M.1    Vohr, H.W.2
  • 37
    • 34250212487 scopus 로고    scopus 로고
    • Primary immune response to sheep red blood cells (SRBC) as the conventional T-cell dependent antibody response (TDAR) test
    • Ladics G.S. Primary immune response to sheep red blood cells (SRBC) as the conventional T-cell dependent antibody response (TDAR) test. J. Immunotoxicol. 2007, 4:149-152.
    • (2007) J. Immunotoxicol. , vol.4 , pp. 149-152
    • Ladics, G.S.1
  • 38
    • 27644436848 scopus 로고    scopus 로고
    • Developmental toxicology evaluations-issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies
    • Ladics G.S., et al. Developmental toxicology evaluations-issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies. Toxicol. Sci. 2005, 88:24-29.
    • (2005) Toxicol. Sci. , vol.88 , pp. 24-29
    • Ladics, G.S.1
  • 39
    • 0033674647 scopus 로고    scopus 로고
    • Characterization of an approach to develoopmental immunotoxicology assessment in the rat using SRBC as the antigen
    • Ladics G.S., et al. Characterization of an approach to develoopmental immunotoxicology assessment in the rat using SRBC as the antigen. Toxicol. Mech. Methods 2000, 10:283-311.
    • (2000) Toxicol. Mech. Methods , vol.10 , pp. 283-311
    • Ladics, G.S.1
  • 40
    • 0031971703 scopus 로고    scopus 로고
    • Further evaluation of the incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats in a standard toxicology study
    • Ladics G.S., et al. Further evaluation of the incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats in a standard toxicology study. Toxicology 1998, 126:137-152.
    • (1998) Toxicology , vol.126 , pp. 137-152
    • Ladics, G.S.1
  • 41
    • 0028953630 scopus 로고
    • Possible incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology study
    • Ladics G.S., et al. Possible incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology study. Toxicology 1995, 96:225-238.
    • (1995) Toxicology , vol.96 , pp. 225-238
    • Ladics, G.S.1
  • 42
    • 84858789018 scopus 로고    scopus 로고
    • Immunotoxicant screening and prioritization in the twenty-first century
    • Luebke R. Immunotoxicant screening and prioritization in the twenty-first century. Toxicol. Pathol. 2012, 40:294-299.
    • (2012) Toxicol. Pathol. , vol.40 , pp. 294-299
    • Luebke, R.1
  • 43
    • 30344473603 scopus 로고    scopus 로고
    • The comparative immunotoxicity of five selected compounds following developmental or adult exposure
    • Luebke R.W., et al. The comparative immunotoxicity of five selected compounds following developmental or adult exposure. J. Toxicol. Environ. Health B Crit. Rev. 2006, 9:1-26.
    • (2006) J. Toxicol. Environ. Health B Crit. Rev. , vol.9 , pp. 1-26
    • Luebke, R.W.1
  • 44
    • 0038408633 scopus 로고    scopus 로고
    • Consensus workshop on methods to evaluate developmental immunotoxicity
    • Luster M.I., et al. Consensus workshop on methods to evaluate developmental immunotoxicity. Environ. Health Perspect. 2003, 111:579-583.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 579-583
    • Luster, M.I.1
  • 45
    • 0023855113 scopus 로고
    • Development of a testing battery to assess chemical-induced immunotoxicity: national toxicology program's guidelines for immunotoxicity evaluation in mice
    • Luster M.I., et al. Development of a testing battery to assess chemical-induced immunotoxicity: national toxicology program's guidelines for immunotoxicity evaluation in mice. Fundam. Appl. Toxicol. 1988, 10:2-19.
    • (1988) Fundam. Appl. Toxicol. , vol.10 , pp. 2-19
    • Luster, M.I.1
  • 46
    • 0026676881 scopus 로고
    • Qualitative and quantitative experimental models to aid in risk assessment for immunotoxicology
    • Spec No
    • Luster M.I., et al. Qualitative and quantitative experimental models to aid in risk assessment for immunotoxicology. Toxicol. Lett. 1992, 64-65:71-78. Spec No.
    • (1992) Toxicol. Lett. , pp. 71-78
    • Luster, M.I.1
  • 47
    • 77957180613 scopus 로고
    • Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests
    • Luster M.I., et al. Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam. Appl. Toxicol. 1993, 21:71-82.
    • (1993) Fundam. Appl. Toxicol. , vol.21 , pp. 71-82
    • Luster, M.I.1
  • 48
    • 77957188471 scopus 로고
    • Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests
    • Luster M.I., et al. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 1992, 18:200-210.
    • (1992) Fundam. Appl. Toxicol. , vol.18 , pp. 200-210
    • Luster, M.I.1
  • 49
    • 78651328041 scopus 로고    scopus 로고
    • T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
    • Martin S.F., et al. T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. Cell. Mol. Life Sci. 2010, 67:4171-4184.
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 4171-4184
    • Martin, S.F.1
  • 51
    • 0031944194 scopus 로고    scopus 로고
    • Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats
    • Miller T.E., et al. Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats. Toxicol. Sci. 1998, 42:129-135.
    • (1998) Toxicol. Sci. , vol.42 , pp. 129-135
    • Miller, T.E.1
  • 57
    • 84890264376 scopus 로고    scopus 로고
    • OECD, Guidance Document 117 on the Current Implementation of Internal Triggers in Test Guideline 443 for an Extended one Generation Reproductive Toxicity Study in the United States and Canada.
    • OECD, 2011b. Guidance Document 117 on the Current Implementation of Internal Triggers in Test Guideline 443 for an Extended one Generation Reproductive Toxicity Study in the United States and Canada., vol. 117.
    • (2011) , vol.117
  • 59
    • 34547500757 scopus 로고    scopus 로고
    • An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential
    • Patlewicz G., et al. An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential. SAR QSAR Environ. Res. 2007, 18:515-541.
    • (2007) SAR QSAR Environ. Res. , vol.18 , pp. 515-541
    • Patlewicz, G.1
  • 60
    • 84878481039 scopus 로고    scopus 로고
    • A step change towards risk assessment in the 21st century
    • Patlewicz G.Y., Lander D.R. A step change towards risk assessment in the 21st century. Front Biosci. (Elite Ed). 2013, 5:418-434.
    • (2013) Front Biosci. (Elite Ed). , vol.5 , pp. 418-434
    • Patlewicz, G.Y.1    Lander, D.R.2
  • 61
    • 0034762255 scopus 로고    scopus 로고
    • Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay
    • Pessina A., et al. Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay. Toxicol. In Vitro 2001, 15:729-740.
    • (2001) Toxicol. In Vitro , vol.15 , pp. 729-740
    • Pessina, A.1
  • 62
    • 79956354131 scopus 로고    scopus 로고
    • Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring
    • Piersma A.H., et al. Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring. Reprod. Toxicol. 2011, 31:392-401.
    • (2011) Reprod. Toxicol. , vol.31 , pp. 392-401
    • Piersma, A.H.1
  • 63
    • 0029128537 scopus 로고
    • Validation of a modified 28-day rat study to evidence effects of test compounds on the immune system
    • Richter-Reichhelm H.B., et al. Validation of a modified 28-day rat study to evidence effects of test compounds on the immune system. Regul. Toxicol. Pharmacol. 1995, 22:54-56.
    • (1995) Regul. Toxicol. Pharmacol. , vol.22 , pp. 54-56
    • Richter-Reichhelm, H.B.1
  • 64
    • 80053645704 scopus 로고    scopus 로고
    • On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe
    • Rorije E., et al. On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe. Regul. Toxicol. Pharmacol. 2011, 61:251-260.
    • (2011) Regul. Toxicol. Pharmacol. , vol.61 , pp. 251-260
    • Rorije, E.1
  • 65
    • 0028269588 scopus 로고
    • Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: differences between mice and rats
    • Smialowicz R.J., et al. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: differences between mice and rats. Toxicol. Appl. Pharmacol. 1994, 124:248-256.
    • (1994) Toxicol. Appl. Pharmacol. , vol.124 , pp. 248-256
    • Smialowicz, R.J.1
  • 66
    • 0035032190 scopus 로고    scopus 로고
    • The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats
    • Smialowicz R.J., et al. The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. Toxicol. Sci. 2001, 61:164-175.
    • (2001) Toxicol. Sci. , vol.61 , pp. 164-175
    • Smialowicz, R.J.1
  • 67
    • 81855168344 scopus 로고    scopus 로고
    • An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8
    • Takahashi T., et al. An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. Toxicol. Sci. 2011, 124:359-369.
    • (2011) Toxicol. Sci. , vol.124 , pp. 359-369
    • Takahashi, T.1
  • 68
    • 84890264377 scopus 로고    scopus 로고
    • US EPA, OPPTS Harmonized Test Guideline: OPPTS 870.7800. Immunotoxicity. EPA/712/C- 98/351. United States Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Washington, DC
    • US EPA, OPPTS Harmonized Test Guideline: OPPTS 870.7800. Immunotoxicity. EPA/712/C- 98/351. United States Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Washington, DC, 1998.
    • (1998)
  • 69
    • 84890267169 scopus 로고    scopus 로고
    • US EPA, Environmental Protection Agency, 40 CFR Parts 9 and 158. Pesticides; Data Requirements for Conventional Chemicals. Federal Register, Vol. 72, No 207 / Friday, October 26.
    • US EPA, 2007. Environmental Protection Agency, 40 CFR Parts 9 and 158. Pesticides; Data Requirements for Conventional Chemicals. Federal Register, Vol. 72, No 207 / Friday, October 26.
    • (2007)
  • 70
    • 84890264378 scopus 로고    scopus 로고
    • US EPA, A Retrospective Analysis of the Immunotoxicity Studies (OCSPP Test Guildeline No. 870.7800). United States Environmental Protection Agency, Health Effects Division, Office of Pesticide Programs
    • US EPA, 2013. A Retrospective Analysis of the Immunotoxicity Studies (OCSPP Test Guildeline No. 870.7800). United States Environmental Protection Agency, Health Effects Division, Office of Pesticide Programs.
    • (2013)
  • 71
    • 0002946077 scopus 로고
    • Immunotoxicological considerations: a practical approach to immunotoxicity testing in the rat
    • Taylor & Francis, London, A.D. Dayan, A.J. Paine (Eds.)
    • van Loveren H., Vos J.G. Immunotoxicological considerations: a practical approach to immunotoxicity testing in the rat. Advances in Applied Toxicology 1989, 143-165. Taylor & Francis, London. A.D. Dayan, A.J. Paine (Eds.).
    • (1989) Advances in Applied Toxicology , pp. 143-165
    • van Loveren, H.1    Vos, J.G.2
  • 72
    • 0017487917 scopus 로고
    • Immune suppression as related to toxicology
    • Vos J.G. Immune suppression as related to toxicology. CRC Crit. Rev. Toxicol. 1977, 5:67-101.
    • (1977) CRC Crit. Rev. Toxicol. , vol.5 , pp. 67-101
    • Vos, J.G.1
  • 73
    • 0019264050 scopus 로고
    • Immunotoxicity assessment: screening and function studies
    • Vos J.G. Immunotoxicity assessment: screening and function studies. Arch. Toxicol. Suppl. 1980, 4:95-108.
    • (1980) Arch. Toxicol. Suppl. , vol.4 , pp. 95-108
    • Vos, J.G.1
  • 74
    • 0013630664 scopus 로고
    • Immunotoxicity Testing
    • In: Burger, E.J., (Eds.), The Rat. Advances In Modern Environmental Toxicology. Princeton Scientific Publishing, Princeton, N.J.
    • Vos, J.G., Van Loveren, H., 1987. Immunotoxicity Testing. In: Burger, E.J., et al., (Eds.), The Rat. Advances In Modern Environmental Toxicology. vol. 13. Princeton Scientific Publishing, Princeton, N.J., pp. 167-180.
    • (1987) , vol.13 , pp. 167-180
    • Vos, J.G.1    Van Loveren, H.2
  • 75
    • 28244436994 scopus 로고    scopus 로고
    • Development of the ICH guidelines for immunotoxicology evaluation of pharmaceuticals using a survey of industry practices
    • Weaver J.L., et al. Development of the ICH guidelines for immunotoxicology evaluation of pharmaceuticals using a survey of industry practices. J. Immunotoxicol. 2005, 2:171-180.
    • (2005) J. Immunotoxicol. , vol.2 , pp. 171-180
    • Weaver, J.L.1
  • 76
    • 0027005012 scopus 로고
    • Validation: state of the art United States national toxicology program & fischer 344 rat cyclosporine-a study
    • White K.L. Validation: state of the art United States national toxicology program & fischer 344 rat cyclosporine-a study. J. Toxicol. Clin. Exp. 1992, 12:429-447.
    • (1992) J. Toxicol. Clin. Exp. , vol.12 , pp. 429-447
    • White, K.L.1
  • 77
    • 84890265724 scopus 로고    scopus 로고
    • Feasibility study to conduct the antibody plaque-forming cell assay and spleen histopathology simultaneously using Fischer 344 rats. 46th Annual Meeting of the Society of Toxicology, Charlotte, NC.
    • Woolhiser, M.R., et al., 2007. Feasibility study to conduct the antibody plaque-forming cell assay and spleen histopathology simultaneously using Fischer 344 rats. 46th Annual Meeting of the Society of Toxicology, Charlotte, NC.
    • (2007)
    • Woolhiser, M.R.1


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