An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 359-369

  Takahashi, Toshiya ^a   Kimura, Yutaka ^a   Saito, Rumiko ^a   Nakajima, Yoshihiro ^b   Ohmiya, Yoshihiro ^b   Yamasaki, Kenshi ^a   Aiba, Setsuya ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Contact dermatitis; IL 8; Luciferase assay; Skin sensitizers

Indexed keywords

ACETYLCYSTEINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; PHOTOSENSITIZING AGENT; PLASMID VECTOR;

ARTICLE; CELL ASSAY; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERLEUKIN 8 REPORTER CELL ASSAY; PROMOTER REGION; PROTEIN INDUCTION; REPORTER GENE; SCREENING TEST; SKIN SENSITIZATION; SLO GENE; SLR GENE;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; CELL LINE; CELL SURVIVAL; DERMATITIS, CONTACT; ENZYME INDUCTION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; SKIN TESTS;

EID: 81855168344     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr237     Document Type: Article

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