The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats

Toxicological Sciences

Volumn 61, Issue 1, 2001, Pages 164-175

  Smialowicz, R J ^a   Williams, W C ^a   Copeland, C B ^a   Harris, M W ^b   Overstreet, D ^b   Davis, B J ^b   Chapin, R E ^b,c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Developmental immunotoxicity; Heptachlor; Heptachlor epoxide; Persistent immune suppression; Pesticide; Rats; Reproductive toxicity

Indexed keywords

HEPTACHLOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MITOGENIC AGENT;

ADOLESCENT; AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; ASSAY; B LYMPHOCYTE; BLOOD LEVEL; CONTACT ALLERGY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DEVELOPMENT; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; EUTHANASIA; EVALUATION; EXPOSURE; FEEDING; FEMALE; GENITAL SYSTEM; GESTATIONAL AGE; HISTOPATHOLOGY; IMMUNE FUNCTION TEST; IMMUNE SYSTEM; JUVENILE; LITTER SIZE; LYMPHOID ORGAN; MILK LEVEL; MIXED LYMPHOCYTE REACTION; NATURAL KILLER CELL; NEWBORN; NONHUMAN; ORGAN; ORGAN WEIGHT; PERINATAL PERIOD; PHYSIOLOGY; PREGNANCY; PUBERTY; RAT; RAT STRAIN; REPRODUCTION; SHEEP; SPLEEN CELL; SURVIVAL; TIME; TISSUE LEVEL;

ANIMALS; ANIMALS, NEWBORN; ANTIBODY FORMATION; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; HEPTACHLOR; HEPTACHLOR EPOXIDE; HYPERSENSITIVITY, DELAYED; IMMUNE SYSTEM; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INSECTICIDES; KILLER CELLS, NATURAL; LITTER SIZE; MALE; MATERNAL EXPOSURE; ORGAN SIZE; PEDIGREE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SEXUAL MATURATION; SPLEEN; T-LYMPHOCYTE SUBSETS; TISSUE DISTRIBUTION;

ANIMALIA; OVIS ARIES;

EID: 0035032190     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/61.1.164     Document Type: Article

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