Specific antibody responses of primary cells from different cell sources are able to predict immunotoxicity in vitro

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1966-1973

  Fischer, A ^a   Koeper, L M ^a   Vohr, H W ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Cytotoxic compounds; Functional assay; Immunosuppressant compounds; In vitro antibody response

Indexed keywords

BENZO[A]PYRENE; CYCLOPHOSPHAMIDE; ERYTHROCYTE ANTIGEN; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CELL KINETICS; CELLULAR IMMUNITY; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; IMMUNOTOXICITY; IN VITRO STUDY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLAQUE FORMING CELL; PREDICTION; RAT; SPECIES DIFFERENCE; SPLEEN CELL;

ALDEHYDES; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIGENS; BENZO(A)PYRENE; BONE MARROW CELLS; CYCLOPHOSPHAMIDE; ERYTHROCYTES; FEMALE; IMMUNOSUPPRESSIVE AGENTS; IRRITANTS; LEUKOCYTES, MONONUCLEAR; MICE; RATS; RATS, INBRED LEW; RATS, WISTAR; SHEEP; SPLEEN; TOXICITY TESTS;

ANIMALIA; MUS; RATTUS;

EID: 82655173956     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.06.020     Document Type: Article

References (42)

1. ATSDR, 1995. Toxicological profile for Polycyclic Aromatic Hydrocarbons (PAHs). U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA.
2. Basketter D.A., Bremmer J.N., Kammüller M.E., Kawabata T., Kimber I., Magda S., Pal T.H.M., Loveless S.E., Stringer D.A., Vohr H.-W. The identification of chemicals with sensitizing or immunosuppressive properties in routine toxicology. Food Chem. Toxicol. 1994, 32:289-296.
3. Blanton R.J., Lyte M., Myers M.J., Bick P.H. Immunomodulation by polyaromatic hydrocarbons in mice and murine cells. Cancer Res. 1986, 46:2735-2739.
4. Bongaards J.J.P., Bertrandoe M., Jacksonoe P., Oudshoorn M.J., Weaver R.J., van Bladeren P.J., Waltheroe B. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000, 30:1131-1152.
5. Burchiel S.W., Luster M.I. Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes. Clin. Immunol. 2001, 98:2-10.
6. Clarke L., Waxman D.J. Oxidative metabolism of cyclophosphamide: identification of hepatic monooxigenase catalysts of drug activation. Cancer Res. 1989, 49:2344-2350.
7. Coecke S., Ahr H., Blaauboer B.J., Bremer S., Casati S., Castell J., Combes R., Corvi R., Crespi C.L., Cunningham M.L., Elaut G., Eletti B., Freidig A., Gennari A., Ghersi-Egea J.-F., Guillouzo A., Hartung T., Hoet P., Ingelman-Sundberg M., Munn S., Janssens W., Ladstetter B., Leahy D., Long A., Meneguz A., Monshouwer M., Morath S., Nagelkerke F., Pelkonen O., Ponti J., Prieto P., Richert L., Sabbioni E., Schaack B., Steiling W., Testai E., Vericat J.-A., Worth A. Metabolism: a bottleneck in in vitro toxicological test development. ATLA 2006, 34:49-84.
8. Colvin O.M. An overview of cyclophosphamide development and clinical applications. Curr. Pharm. Des. 1999, 5:555-560.
9. Connors T.A., Cox P.J., Farmer P.B., Foster A.B., Jarman M. Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem. Pharmacol. 1974, 23:115-129.
10. Diaz-Sanchez D., Tsien A., Casillas A., Dotson A.R., Saxon A. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J. Allergy CIin. Immunol. 1996, 98:114-123.
11. EMA, 2000. CPMP/SWP/1042/99 "Note for guidance on repeated dose toxicity".
12. EPA, 1998. Health Effects Test Guidelines "Immunotoxicity": OPPTS 870.7800.
13. EU, 2006. Regulation (EC) 1907/2006 (REACH).
14. FDA, 2002. Guidance for Industry "Immuntoxicology Evaluation of Investigational New Drugs".
15. Galbiati V., Mitjans M., Corsini E. Present and future of in vitro immunotoxicology in drug development. J. Immunotox. 2010, 7:255-267.
16. Gill T.J., Smith G.J., Wissler R.W., Kunz H.W. The rat as an experimental animal. Science 1989, 245:269-276.
17. Haggerty H.G. Immunotoxicity testing in non-rodent species. J. Immunotox. 2007, 4:165-169.
18. Haley P.J. Species differences in the structure and function of the immune system. Toxicology 2003, 188:49-71.
19. Holsapple M.P. The Plaque-Forming Cell (PFC) Response in Immunotoxicology: An Approach to Monitoring the Primary Effector Function of b-Lymphocytes. Methods in Immunotoxicology 1995, vol. 1:71-108. Wiley-Liss, New York.
20. OECD guidelines for the testing of chemicals on corrosion and irritation No. 430, 431 (2004), 435 (2006), 439 (2010).
21. OECD guidelines for the testing of chemicals on genotoxicity and mutagenicity No. 471, 473, 476 (1997), 479, 480, 481, 482 (1986), 487 (2010).
22. ICH, 2006. Topic S 8 "Note for guidance on immunotoxicity studies for human pharmaceuticals".
23. ICH, 1997. Topic S 6 "Preclinical safety evaluation of biotechnology-derived pharmaceuticals".
24. Jerne N.K., Nordin A.A., Henry C. The Agar Plaque Technique for Recognizing Antibody-Producing Cells. Cell-Bound Antibodies 1963, 109-122. Wistar Institute Press, Philadelphia. B. Amos, H. Koprowski (Eds.).
25. Kimber I. Toxicology and the immune system: a perspective. Hum. Exp. Toxicol. 1991, 10:445-449.
26. Koeper L.M., Vohr H.-W. Functional assays are mandatory for a correct prediction of immunosuppressant properties of compounds in vitro. Food Chem. Toxicol. 2009, 47:110-118.
27. Kutz S.A., Hinsdill R.D., Weltman D.J. Evaluation of chemicals for immunomodulatory effects using an in vitro antibody-producing assay. Environ. Res. 1980, 22:368-376.
28. Ladics G.S., Smith C., Heaps K., Elliott G.S., Slone T.W., Loveless S.E. Possible incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats on standard toxicology study. Toxicology 1995, 96:225-238.
29. Ladics G.S., Smith C., Elliott G.S., Slone T.W., Loveless S.E. Further evaluation of the incorporation of an immunotoxicological functional assay for assessing humoral immunity for hazard identification purposes in rats in a standard toxicology study. Toxicology 1998, 126:137-152.
30. Lang D.S., Meier K.M., Luster M.I. Comparative effects of immunotoxic chemicals on in vitro proliferative responses of human and rodent lymphocytes. Fundam. Appl. Toxicol. 1993, 21:535-545.
31. Loveless S.E., Ladics G.S., Smith C., Holsapple M.P., Woolhiser M.R., Kimber S.E., White L., Musgrove D.L., Smialowicz R.J., Williams W. Interlaboratory study of the primary antibody response to sheep red blood cells in outbred rodents following exposure to cyclophosphamide or dexamethasone. J. Immunotox. 2007, 4:233-238.
32. Lyte M., Bick P.H. Differential immunotoxic effects of the environmental chemical benzo[a]pyrene in young and aged mice. Mech. Aging Dev. 1985, 30:333-341.
33. Luster M.I., Portier C., Pait D.G., White K.L., Gennings C., Munson A.E., Rosenthal G.J. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 1992, 18:200-210.
34. Mishell R.I., Dutton R.W. Immunization of normal mouse spleen cell suspensions in vitro. Science 1966, 153:1004-1006.
35. Richter-Reichhelm H.-B., Dasenbrock C., Descotes G., Emmendörfer A., Heinrich U.E., Harlemann J.H., Hildebrand B., Küttler K., Rühl-Fehlert C.I., Schilling K., Schulte A.E., Vohr H.-W. Validation of a modified 28day rat study to evidence effects of test compounds on the immune system. Regulatory Toxikol. Pharmakol. 1995, 22:54-56.
36. Russell, W.M.S., Burch, R., 1959. The Principles of Humane Experimental Technique. Methuen & Co. Ltd., London. [Reissued, 1992. Universities Federation for Animal Welfare, Herts, England.] http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm.
37. Temple L., Kawabata T.T., Munson A.E., White K.L. Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide. Fundam. Appl. Toxicol. 1993, 21:412-419.
38. Tucker A.N., Sanders V.M., Hallet P., Kauffmann B.M., Munson A.E. In vitro immunotoxicological assays for detection of compounds requiring metabolic activation. Environ. Health Perspect. 1982, 43:123-127.
39. van Grenenynghe J., Rion S., Le Ferrec E., Le Vee M., Amiot L., Fauchet R., Fardel O. Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages. J. Immunol. 2003, 170:2374-2381.
40. Vohr H.-W. Experiences with an advanced screening procedure for the identification of chemicals with an immunotoxic potential in routine toxicology. Toxicology 1995, 104:149-158.
41. Vohr H.-W., Rühl-Fehlert C. Industry experience in the identification of the immunotoxic potential of agrochemicals. Science Total Environm. 2001, 270:123-134.
42. White K.J., Holsapple M.P. Direct suppression of in vitro antibody production by mouse spleen cells by the carcinogen benzo[a]pyrene but not by the congener benzo[e]pyrene. Cancer Res. 1984, 44:3388-3393.