Symposium summary: Children's health risk - What's so special about the developing immune system?

Toxicology and Applied Pharmacology

Volumn 199, Issue 1, 2004, Pages 61-70

  Holsapple, Michael P ^a   Paustenbach, Dennis J ^b   Charnley, Gail ^c   West, Lori J ^d   Luster, Michael I ^e   Dietert, Rodney R ^f   Burns Naas, Leigh Ann ^g  

^a ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

^b CARDNO CHEMRISK   (United States)

^c HealthRisk Strategies   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^f Department of Obstetrics Gynecology   (United States)

^g PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Children's health; Developmental immunotoxicology; Immune; Immunity; Risk

Indexed keywords

CHILD HEALTH; CHILD HEALTH CARE; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENVIRONMENTAL HEALTH; HEALTH CARE POLICY; HEALTH HAZARD; HUMAN; IMMUNE SYSTEM; IMMUNITY; IMMUNOTOXICITY; NONHUMAN; ONTOGENY; RISK ASSESSMENT;

ADOLESCENT; ADULT; AGING; ANIMALS; CHILD; CHILD DEVELOPMENT; CHILD, PRESCHOOL; HUMANS; IMMUNE SYSTEM; INFANT; RISK FACTORS; SOCIETIES, SCIENTIFIC; TOXICOLOGY; UNITED STATES;

EID: 4143049254     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.03.003     Document Type: Conference Paper

References (48)

1. Barnett J.B. Developmental immunotoxicology. Smialowicz R.J., Holsapple M.P. Experimental Immunotoxicology. 1996;47-62 CRC Press, New York
2. Bruckner J.V. Differences in sensitivity of children and adults to chemical toxicity: the NAS panel report. Regul. Toxicol. Pharmacol. 31(3):2000;280-285
3. Bunn T.L., Marsh J.A., Dietert R.R. Gender differences in developmental immunotoxicity to Pb in the chicken: analysis following a single early low-level exposure in ovo. J. Toxicol. Environ. Health, Part A. 61:2000;677-693
4. Bunn T.L., Dietert R.R., Ladics G.S., Holsapple M.P. Developmental immunotoxicity assessment in the rat: age, gender and strain comparisons after exposure to lead. Toxicol. Methods. 11:2001;1-18
5. Bunn T.L., Parsons P.J., Kao E., Dietert R.R. Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender. Toxicol. Sci. 64:2001;57-66
6. Bunn T.L., Parsons P.J., Kao E., Dietert R.R. Gender-based profiles of developmental immunotoxicity to lead in the rat: assessment in juveniles and adults. J. Toxicol. Environ. Health, Part A. 64:2001;101-118
7. Calabrese E.J. Uncertainty factor for children: historical precedent. Hum. Ecol. Risk Assess. 6:2000;729-730
8. Calabrese E.J. Assessing the default assumption that children are always at risk. Human Ecol. Risk Assess. 7:2001;37-59
9. Calabrese E.J., Barnes R., Stanek E.J., Pastides H., Gilbert C.E., Veneman P., Wang X., Lasztity A., Kostecki P.T. How much soil do young children ingest: an epidemiologic study. Regul. Toxicol. Pharmacol. 10:1989;123-137
10. Charnley, G., 2001. Protecting the children: risk assessment, risk management, and children's environmental health reason public policy institute. Policy Study 283. Los Angeles, CA.
11. Dietert R.R., Etzel R.A., Chen D., Halonen M., Holladay S.D., Jarabek A.M., Landreth K., Pinkereton D.B., Smialowicz K., Zoetis R.J. Workshop to identify critical windows of exposure for children's health: immune and respiratory work group summary. Environ. Health Perspect. 108(Suppl. 3):2000;483-490
12. Dietert R.R., Lee J.-E., Bunn T.L. Developmental immunotoxicology: emerging issues. Hum. Exp. Toxicol. 21:2002;479-485
13. Dietert R.R., Lee J.-E., Hussain I., Piepenbrink M. Developmental immunotoxicology of lead. Toxicol. Appl. Pharmacol. 2004;. (in press)
14. Dourson M., Charnley G., Scheuplein R. Differential sensitivity of children and adults to chemical toxicity: II. Risk and regulation. Regul. Toxicol. Pharmacol. 35:2002;448-467
15. Etzel R. Handbook of Pediatric Environmental Health. 1999;American Academy of Pediatrics, Elk Grove Village, IL
16. Fahy O., Senechal S., Pene J., Scherpereel A., Lassalle P., Tonnel A.-B., Yssel H., Wallaert B., Tsicopoulos R. Diesel exhaust favors Th2 cell recruitment by mononuclear cells and alveolar macrophage-derived chemokine on INF-induced protein-10 production. J. Immunol. 168:2002;5912-5919
17. Federal Register, 1996. Food Quality Protection Act (FQPA).
18. Frew A.J., Salvi S.S. Diesel exhaust particles and respiratory allergy. Clin. Exp. Allergy. 27:1997;237-239
19. Ginsberg G., Hattis D., Sonawane B., Russ A., Banati P., Kozlak M., Smolenski S., Goble R. Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. Toxicol. Sci. 66(2):2002;185-200
20. Hattis D., Banati P., Goble R. Distributions of individual susceptibility among humans for toxic effects. How much protection does the traditional tenfold factor provide for what fraction of which kinds of chemicals and effects? Ann. N.Y. Acad. Sci. 895:1999;286-316
21. Hattis D., Banati P., Goble R., Burmaster D.E. Human interindividual variability in parameters related to health risks. Risk Anal. 19:1999;711-726
22. Holladay S.D., Luster M.I. Developmental immunotoxicology. Kimmel C.A., Buelke-Sams J. Developmental Immunotoxicology. 2nd ed.:1994;93-118 Raven Press, New York
23. Holladay S.D., Smialowicz R.J. Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure. Environ. Health Perspect. 108:2000;463-473
24. Holsapple M.P. Developmental immunotoxicity and risk assessment: a workshop summary. Hum. Exp. Toxicol. 21:2002;473-478
25. Holsapple M.P. Developmental immunotoxicity testing: a review. Toxicology. 185(3):2003;193-203
26. Holsapple M., West L., Landreth K. Species comparison of anatomical and functional immune system development. Birth Defects Res. 68(4):2003;321-334
27. Holt P.G. Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period. Environ. Health Perspect. 106(Suppl. 3):1998;795-800
28. Hubal E.A., Sheldon L.S., Burke J.M., McCurdy T.R., Berry M.R., Rigas M.I., Zartarian V.G. Children's exposure assessment: a review of factors influencing children's exposure, and the data available to characterize and assess that exposure. Environ. Health Perspect. 108:2000;475-486
29. Karpuzoglu-Sahin E., Hissong S., Ansar Ahmed S. Interferon-gamma levels are upregulated by 17-B-estradiol and diethylstilbestrol. J. Reprod. Immunol. 52:2001;113-127
30. Kimbrough R., Falk H., Stehr P., Gries G. Health implication of 2,3,7,8 TCDD contamination of residential soil. J. Toxicol. Environ. Health. 14:1984;47-93
31. Ladics G.S., Smith C., Bunn T.L., Dietert R.R., Anderson D.K., Wiescinski C.M., Holsapple M.P. Characterization of an approach to developmental immunotoxicology assessment in the rat using SRBC as the antigen. Toxicol. Methods. 10:2000;283-311
32. Langlois C. Backgrounder on children's environmental health research centers. J. Child. Health. 1:2003;109-116
33. Lee J., Chen S., Golemboski K.A., Parsons P.J., Dietert R.R. Developmental windows of differential lead-induced immunotoxicity in chickens. Toxicology. 156:2001;161-170
34. Lee J., Naqi S.A., Kao E., Dietert R.R. Embryonic exposure to lead: comparison of immune and cellular responses in unchallenged and virally stressed chickens. Arch. Toxicol. 75:2002;717-734
35. Lehman A.J., Fitzhugh O.G. 100-fold margin of safety. Q. Bull.-Assoc. U.S. Food Drug Admin. 18:1954;33
36. Luster M.I., Dean J.H., Germolec D.R. Meeting report: consensus workshop on methods to evaluate developmental immunotoxicity. Environ. Health Perspect. 111:2003;579-583
37. Makris S., Raffaele K., Sette W., Seed J. A retrospective analysis of twelve developmental neurotoxicity studies submitted to the USEPA Office of Prevention, Pesticides, and Toxic Substances (OPPTS). http://www.epa.gov/ scipoly/sap/1998/index.htm:1998
38. Paustenbach D.J. Comments by the editor. J. Child. Health. 1:2003;1-2
39. Peden D.B. Development of atopy and asthma: candidate environmental influences and important periods of exposure. Environ. Health Perspect. 108(Suppl. 3):2000;475-482
40. Renwick A., Lazarus N. Human variability and noncancer risk assessment - An analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol. 27:1998;3-20
41. Scheuplein R., Charnley G., Dourson M. Differential sensitivity of children and adults to chemical toxicity: I. Biological basis. Regul. Toxicol. Pharmacol. 35:2002;429-447
42. Schneider D., Freeman N. Children's Environmental Health. 2000;American Public Health Association, Washington, DC
43. Smialowicz R., Williams W.C., Copeland C.B., Harris M.W., Overstreet D., Davis B.J., Chapin R.E. The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive function in rats. Toxicol. Sci. 61:2001;164-175
44. Stanek E.J., Calabrese E., Zorn M. Soil ingestion distributions for Monte Carlo risk assessment in children. J. Hum. Ecol. Risk Assess. 7:2001;369-387
45. United States Environmental Protection Agency., 1999. Report of the FIFRA scientific advisory panel meeting. A retrospective analysis of developmental neurotoxicity studies. Report No. 99-01B. Arlington, VA.
46. United States Environmental Protection Agency Child-Specific Exposure Factors Handbook. 2002;National Center for Environmental Assessment, Washington, DC
47. United States Environmental Protection Agency., 2003. Supplemental guidance for assessing cancer susceptibility from early life exposure to carcinogens. Federal Register. Feb. 28, 2003.
48. Williams P.R.D., Paustenbach D.J. Current methods for evaluating children's exposures for use in health risk assessment. J. Child. Health. 1(1):2003;41-98