Proapoptotic nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model

Journal of Biological Chemistry

Volumn 282, Issue 2, 2007, Pages 1288-1295

  Wilhelm, Michael ^a   Xu, Zhiheng ^a,b   Kukekov, Nickolay V ^a   Gire, Stephen ^a   Greene, Lloyd A ^a  

^a NewYork Presbyterian Hospital   (United States)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOPRECIPITATION; NIX TRANSCRIPTS; PARKINSON;

CELL DEATH; COPRECIPITATION; DISEASES; IMMUNOLOGY; PHOSPHORYLATION; YEAST;

PROTEINS;

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; OXIDOPAMINE; PERMETHRIN; POSH PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ADRENERGIC RECEPTOR BLOCKING AGENT; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; NIX PROTEIN, MOUSE; POSH PROTEIN, RAT; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETICS; KIDNEY; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PLASMID; PROTEIN BINDING; RAT; TWO HYBRID SYSTEM;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; GREEN FLUORESCENT PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL PROTEINS; NEURONS; OXIDOPAMINE; PARKINSON DISEASE; PC12 CELLS; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; RATS; SYMPATHOLYTICS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33847765450     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607038200     Document Type: Article

References (31)

1. Thomadaki, H., Scorilas, A., and Hindmarsh, J. T. (2006) Crit. Rev. Clin. Lab. Sci. 43, 1-67
2. Chen, G., Cizeau, J., Vande Velde, C., Park, J. H., Bozek, G., Bolton, J., Shi, L., Dubik, D., and Greenberg, A. (1999) J. Biol. Chem. 274, 7-10
3. Boyd, J. M., Malstrom, S., Subramanian, T., Venkatesh, L. K., Schaeper, U., Elangovan, B., D'Sa-Eipper, C., and Chinnadurai, G. (1994) Cell 79, 341-351
4. Farooq, M., Kim, Y., Im, S., Chung, E., Hwang, S., Sohn, M., Kim, M., and Kim, J. (2001) Exp. Mol. Med. 33, 169-173
5. Yussman, M. G., Toyokawa, T., Odley, A., Lynch, R. A., Wu, G., Colbert, M. C., Aronow, B. J., Lorenz, J. N., and Dorn, G. W., 2nd. (2002) Nat. Med. 8, 725-730
6. Imazu, T., Shimizu, S., Tagami, S., Matsushima, M., Nakamura, Y., Miki, T., Okuyama, A., and Tsujimoto, Y. (1999) Oncogene. 18, 4523-4529
7. Yasuda, M., Theodorakis, P., Subramanian, T., and Chinnadurai, G. (1998) J. Biol. Chem. 273, 12415-12421
8. Ray, R., Chen, G., Vande Velde, C., Cizeau, J., Park, J. H., Reed, J. C., Gietz, R. D., and Greenberg, A. H. (2000) J. Biol. Chem. 275, 1439-1448
9. Chen, G., Ray, R., Dubik, D., Shi, L., Cizeau, J., Bleackley, R. C., Saxena, S., Gietz, R. D., and Greenberg, A. H. (1997) J. Exp. Med. 186, 1975-1983
10. Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., Israels, S., Hakem, R., and Greenberg, A. H. (2000) Mol. Cell. Biol. 20, 5454-5468
11. Yasuda, M., D'Sa-Eipper, C., Gong, X. L., and Chinnadurai, G. (1998) Oncogene. 17, 2525-2530
12. Kuan, C. Y., Whitmarsh, A. J., Yang, D. D., Liao, G., Schloemer, A. J., Dong, C., Bao, J., Banasiak, K. J., Haddad, G. G., Flavell, R. A., Davis, R. J., and Rakic, P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 15184-15189
13. Borsello, T., Clarke, P. G., Hirt, L., Vercelli, A., Repici, M., Schorderet, D. F., Bogousslavsky, J., and Bonny, C. (2003) Nat. Med. 9, 1180-1186
14. Eminel, S., Klettner, A., Roemer, L., Herdegen, T., and Waetzig, V. (2004) J. Biol. Chem. 279, 55385-55392
15. Xu, Z., Maroney, A. C., Dobrzanski, P., Kukekov, N. V., and Greene, L. A. (2001) Mol. Cell. Biol. 21, 4713-4724
16. Xu, Z., Kukekov, N. V., and Greene, L. A. (2003) EMBO J. 22, 252-261
17. Xu, Z., Kukekov, N. V., and Greene, L. A. (2005) Mol. Cell. Biol. 25, 9949-9959
18. Xu, Z., Sproul, A., Wang, W., Kukekov, N., and Greene, L. A. (2006) J. Biol. Chem. 281, 303-312
19. Zhang, Q. G., Wang, R. M., Yin, X. H., Pan, J., Xu, T. L., and Zhang, G. Y. (2005) J. Neurochem. 95, 784-795
20. Lei, K., Nimnual, A., Zong, W. X., Kennedy, N. J., Flavell, R. A., Thompson, C. B., Bar-Sagi, D., and Davis, R. J. (2002) Mol. Cell. Biol. 22, 4929-4942
21. Putcha, G. V., Le, S., Frank, S., Besirli, C. G., Clark, K., Chu, B., Alix, S., Youle, R. J., LaMarche, A., Maroney, A. C., and Johnson, E. M., Jr. (2003) Neuron 38, 899-914
22. Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y. N., Campbell, A., Sudha, T., Yuan, Z. M., Narula, J., Weichselbaum, R., Nalin, C., and Kufe, D. (2000) J. Biol. Chem. 275, 322-327
23. Ryu, E. J., Harding, H. P., Angelastro, J. M., Vitolo, O. V., Ron, D., and Greene, L. A. (2002) J. Neurosci. 22, 10690-10698
24. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
25. Kukekov, N. V., Xu, Z., and Greene, L. A. (2006) J. Biol. Chem. 281, 15517-15524
26. Ryu, E. J., Angelastro, J. M., and Greene, L. A. (2005) Neurobiol. Dis. 18, 54-74
27. Bonny, C., Oberson, A., Negri, S., Sauser, C., and Schorderet, D. F. (2001) Diabetes 50, 77-82
28. Birse-Archbold, J.-L. A., Kerr, L. E., Jones, P. A., McCulloch, J., and Sharkey, J. (2005) J. Cereb. Blood Flow Metab. 25, 1356-1365
29. Sowter, H. M., Ratcliffe, P. J., Watson, P., Greenberg, A. H., and Harris, A. L. (2001) Cancer Res. 61, 6669-6673
30. Kuan, C.-Y., and Burke, R. E. (2005) Curr. Drug Target CNS Neurol. Disord. 4, 63-67
31. Galvez, A. S., Brunskill, E. W., Marreez, Y., Benner, B. J., Regula, K. M., Kirschenbaum, L. A., and Dorn, G. W., 2nd. (2006) J. Biol. Chem. 281, 1442-1448