The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains

Acta Neuropathologica

Volumn 97, Issue 3, 1999, Pages 275-278

  Oka, Akira ^a,b   Takashima, Sachio ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Down's syndrome; Glutamate; Metabotropic glutamate receptor; mGluR5

Indexed keywords

AMYLOID PRECURSOR PROTEIN; METABOTROPIC RECEPTOR;

ADOLESCENT; ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHILD; DOWN SYNDROME; FETUS; GERIATRIC PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NEWBORN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RECEPTOR UPREGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ALZHEIMER DISEASE; CELL NUCLEUS; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; CYTOSOL; DOWN SYNDROME; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; MIDDLE AGED; NEURONS; RECEPTORS, METABOTROPIC GLUTAMATE; UP-REGULATION;

EID: 0033019102     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050985     Document Type: Article

References (31)

1. Arai Y, Mizuguchi M, Takashima S (1996) Excessive glutamate receptor 1 immunoreactivity in adult Down syndrome brains. Pediatr Neurol 15: 203-206
2. Armstrong DM, Ikonomovic MD, Sheffield R, Wenthold RJ (1994) AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease. Brain Res 639: 207-216
3. Bar-Peled O, Gross-Isseroff R, Ben-Hur H, Hoskins I, Groner Y, Biegen A (1991) Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1 A receptors. Neurosci Lett 127: 173-176
4. Carlson MD, Penney JBJ, Young AB (1993) NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiol Aging 14: 343-352
5. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634
6. Conn PJ, Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37: 205-237
7. Csernansky JG, Bardgett ME, Sheline YI, Morris JC, Olney JW (1996) CSF excitatory amino acids and severity of illness in Alzheimer's disease. Neurology 46 : 1715-1720
8. Florez J, Del Arco C, Gonzalez A, Pascual J, Pazos A (1990) Autoradiographic studies of neurotransmitter receptors in the brain of newborn infants with Down syndrome. Am J Med Genet Suppl 7 : 301-305
9. Games D, Adams D, Alessandrini R, et al (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373 : 523-527
10. Golden JA, Hyman BT (1994) Development of the superior temporal neocortex is anomalous in trisomy 21. J Neuropathol Exp Neurol 53 : 513-520
11. Goldgaber D, Lerman M, McBride O, Saffiotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235 : 877-880
12. Harris ME, Carney JM, Cole P, Hensley K, Howard BJ, Martin L, Bummer P, Wang Y, Pedigo NWJ, Butterfield DA (1995) β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. NeuroReport 6 : 1875-1879
13. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Ab elevation, and amyloid plaques in transgenic mice. Science 274: 99-102
14. Keller JN, Pang Z, Geddes JW, Begley JG, Germeyer A, Waeg G, Mattson MP (1997) Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid -peptide: role of the lipid peroxidation product 4-hydroxynonenal. J Neurochem 69: 273-284
15. Lee RK, Wurtman RJ, Cox AJ, Nitsch RM (1995) Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci USA 92: 8083-8087
16. Masliah E, Alford M, DeTeresa R, Mallory M, Hansen L (1996) Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40: 759-766
17. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603
18. Nevi R, Finch E, Dawes L (1988) Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1: 669-677
19. Oka A, Takashima S (1997) Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. NeuroReport 8: 1161-1164
20. Parpura-Gill A, Beitz D, Uemura E (1997) The inhibitory effects of b-amyloid on glutamate and glucose uptakes by cultured astrocytes. Brain Res 754: 65-71
21. Pomara N, Singh R, Deptula D, Chou JC, Schwartz MB, LeWitt PA (1992) Glutamate and other CSF amino acids in Alzheimer's disease. Am J Psychiatry 149: 251-254
22. Reid SNM, Romano C, Hughes T, Daw NW (1995) Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1a and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connection. J Comp Neurol 355: 470-477
23. Reynolds GP, Warner CE (1988) Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue. Neurosci Lett 94: 224-227
24. 3H]Aspartate binding in Down's syndrome brains. Brain Res 484: 273-278
25. Sugiyama H, Ito I, Hirono C (1987) A new type of glutamate receptor linked to inositol phospholipids metabolism. Nature 325: 531-533
26. Takashima S, Becker LE, Armstrong DL, Chan F (1981) Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome. A quantitative and qualitative Golgi study. Brain Res 225: 1-21
27. Takashima S, Ieshima A, Nakamura H, Becker LE (1989) Dendrites, dementia, and Down syndrome. Brain Dev 11: 131-133
28. Wisniewski K, Wisniewski H, Wen G (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 17: 278-282
29. Wisniewski KE (1990) Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. Am J Med Genet Suppl 7: 274-281
30. Yankner B (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932
31. Yasuda RP, Ikonomovic MD, Sheffield R, Rubin RT, Wolfe BB, Armstrong DM (1995) Reduction of AMPA-selective glutamate receptor subunits in the entorhinal cortex of patients with Alzheimer's disease pathology: a biochemical study. Brain Res 678: 161-167