Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes

Neurobiology of Disease

Volumn 20, Issue 3, 2005, Pages 685-693

  Albasanz, José Luis ^a   Dalfó, Esther ^b   Ferrer, Isidro ^b,c   Martín, Mairena ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b Institut de Neuropatologia   (Spain)

^c Facultad de Medicina   (Spain)

Author keywords

Alzheimer's disease; Dementia with Lewy bodies; Metabotropic glutamate receptor; Phospholipase C

Indexed keywords

METABOTROPIC RECEPTOR; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA1;

AGED; ALZHEIMER DISEASE; ARTICLE; BINDING ASSAY; BRAIN CORTEX; CLINICAL ARTICLE; COGNITIVE DEFECT; COMPARATIVE STUDY; CORRELATION ANALYSIS; DEMENTIA; DISEASE COURSE; DOWN REGULATION; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; LEWY BODY; MALE; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; RADIOASSAY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BINDING, COMPETITIVE; DISEASE PROGRESSION; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; FRONTAL LOBE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATE; HUMANS; ISOENZYMES; LEWY BODY DISEASE; MALE; MIDDLE AGED; NEURONS; PHOSPHOLIPASE C; RADIOLIGAND ASSAY; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 27744583133     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.05.001     Document Type: Article

References (64)

1. J.L. Albasanz, M. Fernandez, and M. Martin Internalization of metabotropic glutamate receptor in C6 cells through clathrin-coated vesicles Brain Res. Mol. Brain Res. 99 2002 54 66
2. M. Baba, S. Nakajo, P.H. Tu, T. Tomita, K. Nakaya, V.M. Lee, J.Q. Trojanowski, and T. Iwatsubo Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies Am. J. Pathol. 152 1998 879 884
3. C.G. Ballard, J.A. Court, M. Piggott, M. Johnson, J. O'Brien, I. McKeith, C. Holmes, P. Lantos, E. Jaros, R. Perry, and E. Perry Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex Conscious Cogn. 11 2002 461 474
4. F. Bordi, and A. Ugolini Group I metabotropic glutamate receptors: implications for brain diseases Prog. Neurobiol. 59 1999 55 79
5. H. Braak, and E. Braak Temporal sequence of Alzheimer's-disease-related pathology A. Peters J.H. Morrison Neurodegenerative and Age-related Changes in Structure and Function of Cerebral Cortex Cereb. Cortex vol. 14 1999 Kluwer Academic/Plenum Press New York 475 512
6. H. Braak, K. Del Tredici, U. Rub, R.A. de Vos, E.N. Jansen Steur, and E. Braak Staging of brain pathology related to sporadic Parkinson's disease Neurobiol. Aging 24 2003 197 211
7. V. Bruno, G. Battaglia, A. Copani, M. D'Onofrio, P. Di Iorio, A. De Blasi, D. Melchiorri, P.J. Flor, and F. Nicoletti Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs J. Cereb. Blood Flow Metab. 21 2001 1013 1033
8. B.C. Campbell, Q.X. Li, J.G. Culvenor, P. Jakala, R. Cappai, K. Beyreuther, C.L. Masters, and C.A. McLean Accumulation of insoluble α-synuclein in dementia with Lewy bodies Neurobiol. Dis. 7 2000 192 200
9. M.V. Catania, E. Aronica, M.A. Sortino, P.L. Canonico, and F. Nicoletti Desensitization of metabotropic glutamate receptors in neuronal cultures J. Neurochem. 56 1991 1329 1335
10. A.V. Cheng, I.N. Ferrier, C.M. Morris, S. Jabeen, A. Sahgal, I.G. McKeith, J.A. Edwardson, R.H. Perry, and E.K. Perry Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's and Parkinson's diseases J. Neurol. Sci. 106 1991 50 55
11. P.J. Conn, and J.P. Pin Pharmacology and functions of metabotropic glutamate receptors Annu. Rev. Pharmacol. Toxicol. 37 1997 205 237
12. J. Court, C. Martin-Ruiz, M. Piggott, D. Spurden, M. Griffiths, and E. Perry Nicotinic receptor abnormalities in Alzheimer's disease Biol. Psychiatry 49 2001 175 184
13. R.F. Cowburn, C. O'Neill, W.L. Bonkale, T.G. Ohm, and J. Fastbom Receptor-G-protein signalling in Alzheimer's disease Biochem. Soc. Symp. 67 2001 163 175
14. E. Dalfó, J.L. Albasanz, M. Martín, and I. Ferrer Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in Diffuse Lewy Body disease is associated with irregular α-synuclein/ phospholipase C (PLCβ1) interactions Brain Pathol. 14 2004 388 398
15. N.C. Danbolt Glutamate uptake Prog. Neurobiol. 65 2001 1 105
16. A.J. Doherty, V. Coutinho, G.L. Collingridge, and J.M. Henley Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor Biochem. J. 341 1999 415 422
17. I. Ferrer The neuropathological spectrum of Lewy body disorders E. Tolosa J.B. Schulz I.G. McKeith I. Ferrer Neurodegenerative Disorders Associated with α-synuclein Pathology 2002 Ars Medica Barcelona 83 98
18. P.T. Francis Glutamatergic systems in Alzheimer's disease Int. J. Geriatr. Psychiatry 18 2003 S15 S21
19. P.T. Francis, N.R. Sims, A.W. Procter, and D.M. Bowen Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives J. Neurochem. 60 1993 1589 1604
20. P.T. Francis, A.M. Palmer, M. Snape, and G.K. Wilcock The cholinergic hypothesis of Alzheimer's disease: a review of progress J. Neurol., Neurosurg. Psychiatry 66 1999 137 147
21. J.T. Greenamyre, and A.B. Young Excitatory amino acids and Alzheimer's disease Neurobiol. Aging 10 1989 593 602
22. L.A. Hansen, and W. Samuel Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies Neurology 48 1997 126 132
23. M. Hashimoto, and E. Masliah Alpha-synuclein in Lewy body disease and Alzheimer's disease Brain Pathol. 9 1999 707 720
24. C. Hölscher Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis Neurobiol. Dis. 5 1998 129 141
25. L.S. Honig, D.D. Chambliss, E.H. Bigio, S.L. Carroll, and J.L. Elliott Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls Neurology 55 2000 1082 1088
26. J. Hugon, J.M. Vallat, and M. Dumas Role of glutamate and excitotoxicity in neurologic diseases Rev. Neurol. (Paris) 152 1996 239 248
27. P.G. Ince, and I.G. McKeith Dementia with Lewy bodies D. Dickson Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders 2003 ISN Neuropath Press Basel 188 197
28. P.G. Ince, E.K. Perry, and C.M. Morris Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome Brain Pathol. 8 1998 299 324
29. C. Jolly-Tornetta, Z.Y. Gao, V. Lee, and B.A. Wolf Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons J. Biol. Chem. 273 1998 14015 14021
30. + in primary astrocyte cultures J. Neurosci. 9 1989 1141 1149
31. K. Kosaka Dementia and neuropathology in Lewy body disease Adv. Neurol. 60 1993 456 463
32. K. Kosaka, and E. Iseki Diffuse Lewy body disease within the spectrum of Lewy body disease R.H. Perry I.G. McKeith E.K. Perry Dementia with Lewy Bodies 1996 Cambridge Univ. Press Cambridge 238 247
33. P.M. Lea IV, and A.I. Faden Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders Drug News Perspect. 16 2003 513 522
34. R.K. Lee, R.J. Wurtman, A.J. Cox, and R.M. Nitsch Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors Proc. Natl. Acad. Sci. U. S. A. 92 1995 8083 8087
35. R.K. Lee, J. Jimenez, A.J. Cox, and R.J. Wurtman Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats Ann. N. Y. Acad. Sci. 777 1996 338 343
36. P.R. Louzada, A.C. Paula Lima, F.G. de Mello, and S.T. Ferreira Dual role of glutamatergic neurotransmission on amyloid beta (1-42) aggregation and neurotoxicity in embryonic avian retina Neurosci. Lett. 301 2001 59 63
37. M. Martin, J.L. Albasanz, M. Fernandez, and M. Ros Cross-talk between beta-adrenergic and metabotropic glutamate receptors in rat C6 glioma cells Biochem. Biophys. Acta 1393 1998 186 192
38. C. Martin-Ruiz, S. Lawrence, M. Piggott, A. Kuryatov, J. Lindstrom, C. Gotti, M.R. Cookson, R.H. Perry, E. Jaros, E.K. Perry, and J.A. Court Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression Neurosci. Lett. 335 2002 134 138
39. I.G. McKeith Dementia with Lewy bodies Br. J. Psychiatry 180 2002 144 147
40. I.G. McKeith, D. Galasko, and K. Kosaka Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop Neurology 47 1996 1113 1124
41. B. Meldrum, and J. Garthwaite Excitatory amino acid neurotoxicity and neurodegenerative disease Trends Pharmacol. Sci. 11 1990 379 387
42. K. Ohara, N. Kondo, and K. Ohara Changes of monoamines in post-mortem brains from patients with diffuse Lewy body disease Prog. Neuro-Psychopharmacol. Biol. Psychiatry 22 1998 311 317
43. E.K. Perry, E. Marshall, J.S. Kerwin, C.J. Smith, S. Jabeen, A.V. Cheng, and R.H. Perry Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia J. Neurochem. 55 1990 1454 1456
44. E.K. Perry, V. Haroutunian, and K.L. Davis Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease NeuroReport 5 1994 747 749
45. E.K. Perry, C.M. Morris, J.A. Court, A. Cheng, A.F. Fairbairn, I.G. McKeith, D. Irving, A. Brown, and R.H. Perry Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology Neuroscience 64 1995 385 395
46. M.A. Piggott, E.F. Marshall, N. Thomas, S. Lloyd, J.A. Court, E. Jaros, D. Burn, M. Johnson, R.H. Perry, I.G. McKeith, C. Ballard, and E.K. Perry Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution Brain 122 1999 1449 1468
47. 125I]-A-85380 Neuropsychopharmacology 29 2004 108 116
48. J.P. Pin, and R. Duvoisin The metabotropic glutamate receptors: structure and functions Neuropharmacology 3 1995 1 26
49. A.W. Procter, A.M. Palmer, P.T. Francis, S.L. Lowe, D. Neary, E. Murphy, R. Doshi, and D.M. Bowen Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease J. Neurochem. 50 1988 790 802
50. V.L. Rao, K.K. Bowen, and R.J. Dempsey Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain Neurochem. Res. 26 2001 497 502
51. G. Riedel, B. Platt, and J. Micheau Glutamate receptor function in learning and memory Behav. Brain Res. 140 2003 1 47
52. J.D. Rothstein Excitotoxicity hypothesis Neurology 47 1996 S19 S25
53. H.L. Scott, A.E. Tannenberg, and P.R. Dodd Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex J. Neurochem. 64 1995 2193 2202
54. H.L. Scott, D.V. Pow, A.E. Tannenberg, and P.R. Dodd Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease J. Neurosci. 22 2002 RC206
55. K. Shiozaki, and E. Iseki Decrease in GTP-sensitive high affinity agonist binding of muscarinic acetylcholine receptors in autopsied brains of dementia with Lewy bodies and Alzheimer's disease J. Neurol. Sci. 223 2 2004 145 148
56. M. Suzuki, T.J. Desmond, R.L. Albin, and K.A. Frey Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias Ann. Neurol. 51 2002 767 771
57. R.A. Sweet, V.L. Nimgaonkar, M.I. Kamboh, O.L. Lopez, F. Zhang, and S.T. DeKosky Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease Arch. Neurol. 55 1998 1335 1340
58. R.A. Sweet, R.L. Hamilton, M.T. Healy, S.R. Wisniewski, R. Henteleff, B.G. Pollock, D.A. Lewis, and S.T. DeKosky Alterations of striatal dopamine receptor binding in Alzheimer's disease are associated with Lewy body pathology and antemortem psychosis Arch. Neurol. 58 2001 466 472
59. S. Tekin, C. Aykut-Bingol, T. Tanridag, and S. Aktan Antiglutamatergic therapy in Alzheimer's disease-effects of lamotrigine. Short communication J. Neural Transm. 105 1998 295 303
60. V. Thorns, M. Mallory, L. Hansen, and E. Masliah Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer's disease and Lewy body variant Acta Neuropathol. (Berl.) 94 1997 539 548
61. G. Tiger, P.E. Bjorklund, R.F. Cowburn, A. Garlind, C. O'Neill, B. Wiehager, and C.J. Fowler Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex Eur. J. Pharmacol. 188 1990 51 62
62. I.H. Ulus, and R.J. Wurtman Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices J. Pharmacol. Exp. Ther. 281 1997 149 154
63. R.I. Westphalen, H.L. Scott, and P.R. Dodd Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease J. Neural Transm. 110 2003 1013 1027
64. α1 in dorsal prefrontal cortex Mol. Brain Res. 66 1999 188 190