The p53 protein and its molecular network: Modelling a missing link between DNA damage and cell fate

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 1 PART B, 2014, Pages 232-247

  Eliaš, Ján ^a,b   Dimitrio, Luna ^a,b,c   Clairambault, Jean ^a,b   Natalini, Roberto ^d,e  

^a UNIVERSITÉ PIERRE ET MARIE CURIE   (France)

^b INRIA ROCQUENCOURT   (France)

^c SANOFI   (France)

^d CNR   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

ATM; Cell fate; DNA damage; Molecular mathematical model; p53

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 2; HISTONE H2AX; MESSENGER RNA; PROTEIN MDM2; PROTEIN P53;

ACETYLATION; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CELL COMPARTMENTALIZATION; CELL CYCLE PHASE; CELL DEATH; CELL FATE; CELL NUCLEUS; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOSENSITIVITY; COMPUTER SIMULATION; CYTOPLASM; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GAMMA RADIATION; GENE EXPRESSION; GENOMIC INSTABILITY; NEGATIVE FEEDBACK; OSCILLATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; STEADY STATE; SUMOYLATION; TRANSCRIPTION INITIATION; TUMOR CELL; TUMOR GROWTH; UBIQUITINATION; ULTRAVIOLET RADIATION;

ATM; CELL FATE; DNA DAMAGE; MOLECULAR MATHEMATICAL MODEL; P53;

ANTINEOPLASTIC AGENTS; CELL LINEAGE; CELL PROLIFERATION; DNA DAMAGE; GENE REGULATORY NETWORKS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84890118861     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2013.09.019     Document Type: Review

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