Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice

European Journal of Pharmacology

Volumn 721, Issue 1-3, 2013, Pages 70-79

  Park, Sung Bum ^a,b   Jung, Won Hoon ^a   Kang, Nam Sook ^b   Park, Ji Seon ^a   Bae, Gyu Hwan ^a   Kim, Hee Youn ^a   Rhee, Sang Dal ^a   Kang, Seung Kyu ^a   Ahn, Jin Hee ^a   Jeong, Hye Gwang ^b   Kim, Ki Young ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

11 Hydroxysteroid dehydrogenase type 1; Diet induced obese mice; Inflammation; Obesity; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CARBENOXOLONE; CORTICOSTERONE; CORTISONE; ENZYME INHIBITOR; GLYCYRRHETINIC ACID; KR 67105; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N (5 CARBAMOY LADAMANTAN 2 YL) 3 [(2 FLUOROPHENYL)SULFONYL]THIAZOLIDINE 2 CARBOXAMIDE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; GENE EXPRESSION; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; IC 50; INSULIN SENSITIVITY; LIVER; MALE; METABOLIC SYNDROME X; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN PHOSPHORYLATION;

11Β-HYDROXYSTEROID DEHYDROGENASE TYPE 1; DIET-INDUCED OBESE MICE; INFLAMMATION; OBESITY; TYPE 2 DIABETES;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CORTISONE; DIET; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; HYPOTHALAMUS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, OBESE; MODELS, MOLECULAR; OBESITY; PITUITARY-ADRENAL SYSTEM; PROTEIN CONFORMATION; THIAZOLIDINES;

EID: 84890115887     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.09.052     Document Type: Article

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