Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity

Biological Chemistry

Volumn 389, Issue 4, 2008, Pages 441-445

  Taylor, Ashley ^a   Irwin, Nigel ^a   McKillop, Aine M ^a   Flatt, Peter R ^a   Gault, Victor A ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase type 1 (11 HSD1); Carbenoxolone (CBX); Glucose tolerance; Insulin sensitivity; Obesity; Type 2 diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; CORTICOSTERONE; FAT; GLUCOCORTICOID RECEPTOR; GLUCOSE; INSULIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONICITY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOWN REGULATION; FOOD INTAKE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HORMONE ACTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SWISS WEBSTER MOUSE; WEIGHT REDUCTION; ANIMAL; BLOOD; BODY WEIGHT; DRUG ANTAGONISM; DRUG EFFECT; EATING; FAT INTAKE; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CARBENOXOLONE; CORTICOSTERONE; DIETARY FATS; EATING; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; MALE; MICE; OBESITY; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 44649098215     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.049     Document Type: Article

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