Crystal structure of murine 11β-hydroxysteroid dehydrogenase 1: An important therapeutic target for diabetes

Biochemistry

Volumn 44, Issue 18, 2005, Pages 6948-6957

  Zhang, Jiandong ^a   Osslund, Timothy D ^a   Plant, Matthew H ^a   Clogston, Christi L ^a   Nybo, Rebecca E ^a   Xiong, Fei ^a   Delaney, John M ^a   Jordan, Steven R ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERS; DISEASES; METABOLISM; REDUCTION; X RAY CRYSTALLOGRAPHY;

DIABETES; OBESITY; RODENTS; STEROID DEHYDROGENASES (SDH);

ENZYMES;

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; GLUCOCORTICOID; STEROID REDUCTASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME CONFORMATION; HUMAN; HYDROPHOBICITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CORTICOSTERONE; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; DIMERIZATION; DRUG DELIVERY SYSTEMS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NADP; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY;

MURINAE; RODENTIA;

EID: 18244364603     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047599q     Document Type: Article

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