A metabolomics investigation of non-genotoxic carcinogenicity in the rat

Journal of Proteome Research

Volumn 12, Issue 12, 2013, Pages 5775-5790

  Ament, Zsuzsanna ^a,b,c   Waterman, Claire L ^d   West, James A ^a,b,c   Waterfield, Catherine ^e   Currie, Richard A ^e   Wright, Jayne ^e   Griffin, Julian L ^a,b,c  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d SYNGENTA CROP PROTECTION AG   (Switzerland)

^e Syngeta International Research Centre   (United Kingdom)

Author keywords

CAR receptor; lipidomics; metabolomics; non genotoxic carcinogens; PPAR alpha agonist

Indexed keywords

CARCINOGEN; FATTY ACID; ICOSANOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; XENOBIOTIC AGENT; BIOLOGICAL MARKER; MUTAGENIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; INFLAMMATION; LIPIDOMICS; LIVER CARCINOGENESIS; MALE; MAXIMUM TOLERATED DOSE; METABOLOMICS; NONHUMAN; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; RAT; AGONISTS; ANIMAL; CHEMICALLY INDUCED; CLASSIFICATION; DNA DAMAGE; DRUG EFFECTS; EXPERIMENTAL LIVER NEOPLASM; FISCHER 344 RAT; GENE EXPRESSION; GENETICS; HUMAN; LIPID METABOLISM; LIVER; METABOLISM; PATHOLOGY; TOXICITY;

ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS; DNA DAMAGE; EICOSANOIDS; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION; HUMANS; LIPID METABOLISM; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; METABOLOMICS; MUTAGENS; PHOSPHOLIPIDS; PPAR ALPHA; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; TRIGLYCERIDES;

EID: 84890081556     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr4007766     Document Type: Article

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