The national toxicology program rodent bioassay: Designs, interpretations, and scientific contributions

Annals of the New York Academy of Sciences

Volumn 982, Issue , 2002, Pages 198-207

  Bucher, John R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Bioassays; Carcinogenesis; Dioxins; National Toxicology Program; Photocarcinogenicity; Phototoxicology; Rodent

Indexed keywords

DIOXIN;

BIOASSAY; CANCER PREVENTION; CARCINOGEN TESTING; CARCINOGENESIS; CARCINOGENICITY; CONFERENCE PAPER; DATA ANALYSIS; DOSE RESPONSE; METHODOLOGY; MOUSE; NONHUMAN; NUDE MOUSE; PHOTOTOXICITY; SKIN PAPILLOMA; STATISTICAL ANALYSIS; TOXICOKINETICS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0036965403     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04934.x     Document Type: Conference Paper

References (12)

1. HASEMAN, J.K. 1984. Statistical issues in the design, analysis, and interpretation of animal carcinogenicity studies. Environ. Health Perspect. 58: 385-392.
2. BUCHER, J.R. et al. 1996. Workshop overview: National Toxicology Program studies: principles of dose selection and applications to mechanistic based risk assessment. Fundam. Appl. Toxicol. 31: 1-8.
3. FORAN, J.A., Ed. 1997. Principles for the Selection of Doses in Chronic Rodent Bioassays. ILSI Risk Sciences Institute. ILSI Press. Washington, DC.
4. BUCHER, J.R. 2000. Doses in rodent cancer studies: sorting fact from fiction. Drug Metab. Rev. 32: 153-164.
5. GAYLOR, D.W. et al. 1985. Experimental design of bioassays for screening and low dose extrapolation. Risk Analysis 5: 9-16
6. WARD, J.M. et al. 1995. Peer review in toxicologic pathology. Toxicol. Pathol. 23: 226-234.
7. SILLS, R.C. et al. 1999. High frequency of codon 61 K-ras A → T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene, Carcinogenesis 20: 657-662.
8. DEVEREUX, T.R. et al. 1994. Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet. Carcinogenesis 15: 1083-1087.
9. VAN BIRGELEN, A.P.J.M. et al. 1997. Design of 2-year bioassays with dioxin-like compounds in female Sprague Dawley rats. Organohalogen Compounds 34: 154-159.
10. SOFFRITTI, M. et al. 1999. Mega-experiments to identify and assess diffuse carcinogenic risks. Ann. N.Y. Acad. Sci. 895: 34-55.
11. MALTONI, C. et al. 1999. The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks. Ann. N.Y. Acad. Sci. 895: 10-26.
12. HUFF, J. 1999. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans. In Carcinogenicity Testing, Predicting, and Interpreting Chemical Effects. K.T. Kitchin, Ed.: 2: 21-123. Marcel Dekker. New York.