Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats

Fundamental and Applied Toxicology

Volumn 29, Issue 2, 1996, Pages 219-228

  Kolaja, Kyle L ^a   Stevenson, Donald E ^b   Johnson, Jason T ^a   Walborg Jr , Earl F ^b   Klaunig, James E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dermigen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIELDRIN; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; LIVER; LIVER CELL; LIVER TOXICITY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SPECIES DIFFERENCE;

EID: 85033061341     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0025     Document Type: Article

References (40)

1. Ames, B. N., and Gold, L. S. (1990). Chemical carcinogenesis: Too many rodent carcinogens. Proc Natl. Acad. Sci. USA 87, 7772-7776.
2. Ashwood-Smith, M. J. (1981). The genetic toxicology of aldrin and dieldrin. Mutat. Res. 86, 137-154.
3. Bidwell, K. E., Weber, E., Neinhold, I., Connor, C., and Legator, M. S. (1975). Comprehensive evaluation for mutagenic activity of dieldrin. Mutat. Res. 31(5), 314-320.
4. Butterworth, B. E. (1990). Consideration of both genotoxic and nongenotoxic mechanism in predicting carcinogenesis potential. Mutat. Res. 239, 117-132.
5. Butterworth, B. E., and Goldsworthy, T. L. (1991). The role of cell proliferation in multi-stage carcinogenesis Proc. Soc. Exp. Biol. Med. 198, 683-687.
6. Cabrai, J. H. P., Hall, R. K., Bronczyk, S. A., and Shubik, P. (1979). A genicity study of the pesticide dieldrin in hamsters Cancer Lett. 6, 241-246.
7. Cleveland, F. P. (1966). A summary of work on aldrin and dieldrin toxicity at the Kettering Laboratory. Arch. Environ. Health 13, 195-198.
8. Cohen, S. M., and Ellwein, L. B. (1988). A cellular dynamics model of experimental bladder cancer: Analysis of the effect of sodium saccharin in the rat. Toxicol. Lett. 43, 151.
9. Cohen, S. M., and Ellwein, L. B. (1990). Cell proliferation in carcinogenesis. Science 249, 1007-1011.
10. Cohen, S. M., and Ellwein, L. B. (1991). Genetic errors, cell proliferation, and Carcinogenesis. Cancer Res. 51, 6393-6505.
11. Cunningham, M. L., Foley, J., Maronpot, R. R., and Mathews, H. B. (1991). Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair-2,6 and 2,4 diaminotoulene. Toxicol. Appl. Pharmacol. 107, 562-567.
12. Cunningham, M. L., Maronpot, R. R., Thompson, M., and Bucher J. R. (1994). Early responses of the liver of B6C3F1 mice to the hepatocarcinogen Oxazepam. Toxicol. Appl. Pharmacol. 124, 31-38.
13. Davis, K. J., and Fitzhugh, O. G. (1962). Tumorogenic potential of aldrin and dieldrin for mice. Toxicol. Appl. Pharmacol. 4, 187-189.
14. Eacho, P. I., Lanier, T. L., and Brodhecker, C. A. (1991). Hepatocellular DNA synthesisin rats given peroxisome proliferating agents: Comparison of WY-14,643 to clofibric acid, nafenopin, and LY171883. Carcinogenesis 12, 1557-1561.
15. 3H]-thymidine administered by injection or osmotic pump. Carcinogenesis 11, 2245-2251.
16. Eldridge, S. R., Goldsworthy, T. L., Popp, J. A., and Butterworth, B. E. (1992). Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration. Carcinogenesis 13, 409-415.
17. Gad, S., and Weil, C. S. (1986). Statistics and Experimental Design for Toxicologists. Telford Press, New Jersey.
18. Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmermann-Trosiener, I., and Schulte-Hermann, R. (1990). Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis 11, 617-624.
19. Grasl-Kraupp, B., Walduhor, T., Huber, W., and Schulte-Hermann, R. (1993). Glutathione-S-transferase isoenzyme patterns in different sub-types of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital. Carcinogenesis 14, 2407-2412.
20. Huff, J. E. (1993). Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis. Environ. Health Perspect. 101(Suppl. 5), 45-53.
21. Klaunig, J. E. (1993). Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital. Environ. Health Perspect. 101(Suppl. 5), 235-249.
22. Klaunig, J. E., Siglin, J. C., Schafer, L. D., Hartnett, J. A., Weghorst, C. M., Olsen, M. J., and Hampton, J. A. (1991). Correlation between species and tissue sensitivity to chemical Carcinogenesis in rodents and the induction of DNA synthesis. In Chemically Induced Cell Proliferation: Implications for Risk Assessment (B. E. Butterworth, T. J. Slaga, W. Farland, and M. McClain, Eds.), pp. 193-205. Wiley-Liss, New York.
23. Larson, J. L., Wolf, D. C., and Butterworth, B. E. (1993). Acute hepatotoxic and nephrotoxic effects of chloroform in male F344 rats and B6C3F1 mice. Fundam. Appl. Toxicol. 20, 302-315.
24. Loury, D. J., Goldsworthy, T. L., and Butterworth, B. E. (1987). The value of measuring cell replication as a predictive index of tissue-specific tumorgenic potential. In Nongenotoxic Mechanisms in Carcinogenesis (B. E. Butterworth and T. J. Slaga, Eds.), Banbury Report 25, pp. 119-136. Cold Spring Harbor Laboratory Press, Cold Springs Harbor, New York.
25. Malansky, C. J., and Williams, G. M. (1980). Evidence for an epigenetic mode of action in organochlorine pesticide hepatocarcinogenicity: A lack of genotoxicity in rat, mouse, and hamster hepatocytes. J. Tox. Environ. Health 8, 121-130.
26. Marshall, T. C., Dorough, H. W., and Swim, H. E. (1976). Screening of pesticides for mutagenic potential using Salmonella tymphimurium mutants. J. Agric. Food Chem. 24, 560-563.
27. Melnick, R. L. (1992). Does chemically induced hepatocyte proliferation predict liver carcinogens? FASEB J. 6, 2698-2706.
28. Melnick, R. L., and Huff, J. (1993). Liver carcinogenesis is not a predicted outcome of chemically induced hepatocyte proliferation. Toxicol. Ind. Health 9, 415-438.
29. NCI (1978). Bioassay of Aldrin and Dieldrin for Possible Carcinogenicity. National Cancer Institute (DHEW publication No. (NIH) 78-821, 822), Bethesda, MD.
30. Saady, J. J., and Poklis, A. (1990). Determination of Chlorinated hydrocarbon pesticides by solid phase extraction and capillary GC with electron capture detection. J. Anal. Tox. 14, 301-304.
31. Schulte-Hermann, R. S. (1987). Tumor promotion in the liver. Arch. Toxicol. 57, 147-158.
32. Schulte-Hermann, Bursch, Fesus, L., Timmermann-Trosiener, I., Krapp, B., and Liehr, J. (1990). Role of cell death in hepatocarcinogenesis In Liver Cell Cancer. (P. Bannasch, D. Keppler, and G. Weber, Eds), pp. 339-350. Kluwer Academic, Dorderecht.
33. Shirasu, Y. M., Moriya, K., Kato, K., Lienard, F., Tezuka, H., Terramoto, S., and Kada, T. (1977). Mutagenicity screening on pesticides and modification products A basis of carcinogenic evaluation. Origins Hum. Cancer 1, 267-270.
34. Simmons, V. F., Kauhanen, K., and Tardiff, R. G. (1977). Mutagenic activity of chemicals identified in drinking water. Devalop. Toxicol. Environ. Sci. 2, 249-258.
35. Stevenson, D. E., and Walker, A. I. T. (1969). Hepatic lesions produced in mice by dieldrin and other hepatic enzyme-inducing compounds. J. Eur. Toxicol. 2, 83-84.
36. Thorpe, E., and Walker, A. I. T. (1973). The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies with special reference to aldrin and dieldrin. Food Cosmetic Toxicol. 11, 433-442.
37. van Ravenzwaay, B., Tennekes, H., Stohr, M., and Kunz, W. (1987). The kinetics of nuclear polyploidization and tumor formation in livers of CF-1 mice exposed to dieldrin. Carcinogenesis 8, 265-269.
38. Wright, A. S., Ajkintonwa, D. A. A., and Wooder, M. F. (1977). Studies on the interactions of dieldrin with mammalian liver cells at the subcellular level. Ecotoxicol. Environ. Saf. 1, 7-16, 427.
39. Wright, A. S., Potter, D., Wooder, M. F., Donninger, C., and Greenland, R. D. (1972). The effects of dieldrin on the subcellular structure and function of mammalian liver cells. Food Cosmet. Toxicol. 10, 311-332.
40. Wright, A. S., Donninger, C., Greenland, R. D., Stemmer, K. L., and Zavon, M. R. (1978). The effects of prolonged ingestion of dieldrin on the livers of male rhesus monkeys Ecotoxicol. Environ. Saf. 1, 477-502.