An integrated functional genomic study of acute phenobarbital exposure in the rat

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Waterman, Claire L ^a   Currie, Richard A ^b   Cottrell, Lisa A ^b   Dow, Jacky ^b   Wright, Jayne ^b   Waterfield, Catherine J ^b   Griffin, Julian L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; FATTY ACID; GLUTATHIONE; GLYCOGEN; HEME; PHENOBARBITAL; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; FATTY ACID TRANSPORT; FUNCTIONAL GENOMICS; GLUTATHIONE METABOLISM; GLYCOGEN LIVER LEVEL; GLYCOGEN SYNTHESIS; HEME SYNTHESIS; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; MALE; MASS SPECTROMETRY; METABOLOMICS; MULTIVARIATE ANALYSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN INDUCTION; RAT; SMOOTH ENDOPLASMIC RETICULUM; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CLUSTER ANALYSIS; DRUG EFFECT; FISCHER 344 RAT; GENE EXPRESSION PROFILING; LIVER; MASS FRAGMENTOGRAPHY; METABOLISM; METABOLOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PLASMA; PRINCIPAL COMPONENT ANALYSIS;

RATTUS; RODENTIA;

ANIMALS; CLUSTER ANALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION PROFILING; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; MULTIVARIATE ANALYSIS; OXIDATIVE STRESS; PHENOBARBITAL; PLASMA; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED F344;

EID: 77249115351     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-9     Document Type: Article

References (38)

1. Elcombe CR, Odum J, Foster JR, Stone S, Hasmall S, Soames AR, Kimber I, Ashby J. Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environ Health Perspect 2002, 110(4):363-375. 1240799, 11940454.
2. Ward JM, Uno H, Kurata Y, Weghorst CM, Jang JJ. Cell proliferation not associated with carcinogenesis in rodents and humans. Environ Health Perspect 1993, 101(Suppl 5):125-135. 10.2307/3431855, 1519455, 8013399.
3. Carthew P, Edwards RE, Nolan BM. The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. Toxicol Sci 1998, 44(1):46-51. 10.1093/toxsci/44.1.46, 9720140.
4. Staubli W, Hess R, Weibel ER. Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes. J Cell Biol 1969, 42(1):92-112. 10.1083/jcb.42.1.92, 2107585, 4306789.
5. Butler WH. Long-term effects of phenobarbitone-Na on male Fischer rats. Br J Cancer 1978, 37(3):418-423. 2009530, 638020.
6. Saito R, Chandar N, Janosky JE, Lombardi B. No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat. Res Commun Chem Pathol Pharmacol 1990, 69(2):197-207.
7. Hagiwara A, Miyata E, Tamano S, Sano M, Masuda C, Funae Y, Ito N, Fukushima S, Shirai T. Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. Food Chem Toxicol 1999, 37(8):869-879. 10.1016/S0278-6915(99)00072-1, 10506011.
8. Rossi L, Ravera M, Repetti G, Santi L. Long-Term Administration of Ddt or Phenobarbital-Na in Wistar Rats. International Journal of Cancer 1977, 19(2):179-185.
9. Isenberg JS, Kamendulis LM, Ackley DC, Smith JH, Pugh G, Lington AW, McKee RH, Klaunig JE. Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents. Toxicol Sci 2001, 64(2):192-199. 10.1093/toxsci/64.2.192, 11719701.
10. Clayton TA, Lindon JC, Everett JR, Charuel C, Hanton G, Le Net JL, Provost JP, Nicholson JK. An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. Arch Toxicol 2003, 77(4):208-217.
11. Mortishire-Smith RJ, Skiles GL, Lawrence JW, Spence S, Nicholls AW, Johnson BA, Nicholson JK. Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity. Chem Res Toxicol 2004, 17(2):165-173. 10.1021/tx034123j, 14967004.
12. Nicholls AW, Holmes E, Lindon JC, Shockcor JP, Farrant RD, Haselden JN, Damment SJ, Waterfield CJ, Nicholson JK. Metabonomic investigations into hydrazine toxicity in the rat. Chem Res Toxicol 2001, 14(8):975-987. 10.1021/tx000231j, 11511171.
13. Ala-Korpela M, Lankinen N, Salminen A, Suna T, Soininen P, Laatikainen R, Ingman P, Jauhiainen M, Taskinen MR, Heberger K, et al. The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent. Atherosclerosis 2007, 190(2):352-358. 10.1016/j.atherosclerosis.2006.04.020, 16730730.
14. Ferrer JC, Favre C, Gomis RR, Fernandez-Novell JM, Garcia-Rocha M, de la Iglesia N, Cid E, Guinovart JJ. Control of glycogen deposition. FEBS Lett 2003, 546(1):127-132. 10.1016/S0014-5793(03)00565-9, 12829248.
15. Notten WRF, Henderson PT, Kuyper CMA. Stimulation of Glucuronic Acid Pathway in Isolated Rat-Liver Cells by Phenobarbital. International Journal of Biochemistry 1975, 6(10):713-718.
16. Betschart JM, Virji MA, Gupta C, Shinozuka H. Alterations induced by phenobarbital, a liver tumor promoter, in hepatocyte receptors for insulin and glucagon and glycogen metabolism. Carcinogenesis 1988, 9(7):1289-1294. 10.1093/carcin/9.7.1289, 2838198.
17. Chaudhary IP, Tuntaterdtum S, McNamara PJ, Robertson LW, Blouin RA. Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. J Pharmacol Exp Ther 1993, 265(3):1333-1338.
18. Johnson DR, Habeebu SS, Klaassen CD. Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. Toxicol Sci 2002, 66(1):16-26. 10.1093/toxsci/66.1.16, 11861969.
19. Kaplowitz N, Kuhlenkamp J, Goldstein L, Reeve J. Effect of salicylates and phenobarbital on hepatic glutathione in the rat. J Pharmacol Exp Ther 1980, 212(2):240-245.
20. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 1999, 27(9-10):922-935. 10.1016/S0891-5849(99)00176-8, 10569625.
21. Stengard JH, Saarni HU, Sotaniemi EA. Medroxyprogesterone acetate (MPA) enhances liver NADPH-generating enzyme activities in normal rats. Gen Pharmacol 1988, 19(3):377-380.
22. Ades IZ. Heme production in animal tissues: the regulation of biogenesis of delta-aminolevulinate synthase. Int J Biochem 1990, 22(6):565-578. 10.1016/0020-711X(90)90032-X, 2199251.
23. Varone CL, Giono LE, Ochoa A, Zakin MM, Canepa ET. Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase. Arch Biochem Biophys 1999, 372(2):261-270. 10.1006/abbi.1999.1470, 10600163.
24. Kakizaki S, Yamamoto Y, Ueda A, Moore R, Sueyoshi T, Negishi M. Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR. Biochim Biophys Acta 2003, 1619(3):239-242.
25. Staels B, Auwerx J. Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models. Development 1992, 115(4):1035-1043.
26. Peinado-Onsurbe J, Staels B, Deeb S, Ramirez I, Llobera M, Auwerx J. Neonatal extinction of liver lipoprotein lipase expression. Biochim Biophys Acta 1992, 1131(3):281-286.
27. Orrenius S, Ericsson JL. Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes. J Cell Biol 1966, 28(2):181-198. 10.1083/jcb.28.2.181, 2106923, 5914688.
28. Orrenius S, Ericsson JL, Ernster L. Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol 1965, 25(3):627-639. 10.1083/jcb.25.3.627, 2106691, 4378769.
29. Haghighi AZ, Pynadath TI. Stimulation of prostacyclin synthesis in rats treated with phenobarbital. Prostaglandins Leukot Med 1987, 28(3):267-275. 10.1016/0262-1746(87)90116-8, 3310014.
30. Gygi SP, Rochon Y, Franza BR, Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 1999, 19(3):1720-1730. 83965, 10022859.
31. Fiehn O. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comparative and Functional Genomics 2001, 2(3):155-168. 10.1002/cfg.82, 2447208, 18628911.
32. Le Belle JE, Harris NG, Williams SR, Bhakoo KK. A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed 2002, 15(1):37-44. 10.1002/nbm.740, 11840551.
33. Gullberg J, Jonsson P, Nordstrom A, Sjostrom M, Moritz T. Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry. Anal Biochem 2004, 331(2):283-295. 10.1016/j.ab.2004.04.037, 15265734.
34. Morrison WR, Smith LM. Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride--Methanol. J Lipid Res 1964, 5:600-608.
35. Dunnett CW. New Tables for Multiple Comparisons with a Control. Biometrics 1964, 20(3):482-491.
36. Lindon JC, Holmes E, Nicholson JK. Pattern recognition methods and applications in biomedical magnetic resonance. Progress in Nuclear Magnetic Resonance Spectroscopy 2001, 39(1):1-40.
37. Currie RA, Bombail V, Oliver JD, Moore DJ, Lim FL, Gwilliam V, Kimber I, Chipman K, Moggs JG, Orphanides G. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. Toxicol Sci 2005, 86(2):453-469. 10.1093/toxsci/kfi207, 15901911.
38. Pears MR. Metabolomic Investigation of the Neuronal Ceroid Lipofuscinoses. PhD Thesis 2006, University of Cambridge.