The danger signal plus DNA damage two-hit hypothesis for chronic inflammation in COPD

European Respiratory Journal

Volumn 42, Issue 6, 2013, Pages 1689-1695

  Aoshiba, Kazutetsu ^a   Tsuji, Takao ^a   Yamaguchi, Kazuhiro ^b   Itoh, Masayuki ^a   Nakamura, Hiroyuki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CARCINOGENESIS; CELL AGING; CELL INFILTRATION; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DISEASE SEVERITY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; HUMAN; IMMUNE RESPONSE; INFLAMMATORY CELL; LUNG ALVEOLUS CELL; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SMOKING;

ANIMALS; APOPTOSIS; CELL AGING; CHRONIC DISEASE; CYTOKINES; DNA DAMAGE; HUMANS; INFLAMMATION; MICE; OXIDATIVE STRESS; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SMOKING; SMOKING CESSATION;

EID: 84890081140     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00102912     Document Type: Review

References (57)

1. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 2009; 360: 2445-2454.
2. Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive disease. Lancet 2011; 378: 1015-1026.
3. Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 2009; 135: 173-180.
4. Faner R, Rojas M, MacNee W, et al. Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012; 186: 306-313.
5. Tuder RM, Petrache I. Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest 2012; 122: 2749-2755.
6. Yao H, Rahman I. Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. Am J Physiol Lung Cell Mol Physiol 2012; 303: L557-L566.
7. Hasty P, Campisi J, Hoeijmakers J, et al. Aging and genome maintenance: lessons from the mouse? Science 2003; 299: 1355-1359.
8. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296: 301-305.
9. Lee SH, Goswami S, Grudo A, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 2007; 13: 567-569.
10. Cottin V, Fabien N, Khouatra C, et al. Anti-elastin autoantibodies are not present in combined pulmonary fibrosis and emphysema. Eur Respir J 2009; 33: 219-221.
11. Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177: 156-163.
12. Núñez B, Sauleda J, Antó JM, et al. Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 183: 1025-1031.
13. Cousssens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-867.
14. Internal Agency for Research on Cancer. Chronic infections. In: Stewart BW, Kleihues P, eds. World Cancer Report 2003. Lyon, IARC Press, 2003; pp. 56-61.
15. Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009; 9: 375-383.
16. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-370.
17. Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer 2011; 128: 1999-2009.
18. Hiraku Y, Kawanishi S, Ichinose T, et al. The role of iNOS-induced DNA damage in infection- and asbestosinduced carcinogenesis. Ann NY Acad Sci 2010; 1203: 15-22.
19. Murata M, Thanan R, Ma N, et al. Role of nitrative and oxidative DNA damage in inflammation-induced carcinogenesis. J Biomed Biotechnol 2012; 2012: 623019.
20. Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, et al. Molecular mechanisms of mammalian DNA repair and the DNA damage check points. Annu Rev Biochem 2004; 73: 39-85.
21. Acosta JC, O'Loghlen A, Banito A, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008; 133: 1006-1018.
22. Kuilman T, Michaloglou C, Vredeveld LC, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133: 1019-1031.
23. Kuilman T, Michaloglou C, Mooi WJ, et al. The essence of senescence. Genes Dev 2010; 24: 2463-2479.
24. Freund A, Orjalo AV, Desprez PY, et al. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-246.
25. Rodier F, Coppé JP, Patil CK, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11: 973-979.
26. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192: 547-556.
27. Coppé JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6: 2853-2868.
28. Tilstra JS, Robinson AR, Wang J, et al. NF-kB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest 2012; 122: 2601-2612.
29. Orajo AV, Bhaumik D, Gengler BK, et al. Cell-surface-bound IL-1α is an upstream regulator of the senescenceassociated IL-6/IL-8 cytokine network. Proc Natl Acad Sci USA 2009; 106: 17031-17036.
30. Westbrook AM, Schiestl RH. Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res 2010; 70: 1875-1884.
31. Toyooka T, Ibuki Y. Cigarette sidestream smoke induces phosphorylated histone H2AX. Mutat Res 2009; 676: 34-40.
32. Siafakas NM, Tzortzaki EG, Sourvinos G, et al. Microsatellite DNA stability in COPD. Chest 1999; 116: 47-51.
33. Zervou MI, Tzortzaki EG, Makris D, et al. Differences in microsatellite DNA level between asthma and chronic obstructive pulmonary disease. Eur Respir J 2006; 28: 472-478.
34. Samara KD, Tzortzaki EG, Neofytou E, et al. Somatic DNA alterations in lung epithelial barrier cells in COPD patients. Pulm Pharmacol Ther 2010; 23: 208-214.
35. Deslee G, Woods JC, Moore C, et al. Oxidative damage to nucleic acids in severe emphysema. Chest 2009; 135: 965-974.
36. Pastukh VM, Zhang L, Ruchko MV, et al. Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences. Int J Chron Obstruct Pulmon Dis 2009; 6: 209-217.
37. Qiu W, Baccarelli A, Carey VJ, et al. Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function. Am J Respir Crit Care Med 2012; 185: 373-381.
38. Aoshiba K, Zhou F, Tsuji T, et al. DNA damage as a molecular link in the pathogenesis of COPD in smokers. Eur Respir J 2012; 39: 1368-1376.
39. Shi Y, Cao J, Gao J, et al. Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema. Am J Respir Crit Care Med 2012; 186: 412-419.
40. Ceylan E, Kocyigit A, Gencer M, et al. Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass. Respir Med 2006; 100: 1270-1276.
41. Maluf SW, Mergener M, Dalcanale L, et al. DNA damage in peripheral blood of patients with COPD. Mut Res 2007; 626: 180-184.
42. Tzortzaki EG, Siafakas NM. A hypothesis for the initiation of COPD. Eur Respir J 2009; 34: 310-315.
43. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration 2010; 80: 59-70.
44. Mah LJ, El-Osta A, Karagiannis TC. γH2AX as a molecular marker of aging and disease. Epigenetics 2010; 5: 129-136.
45. Aoshiba K, Nagai A. Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009; 6: 596-601.
46. Amsellem V, Gary-Bobo G, Marcos E, et al. Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 184: 1358-1366.
47. Zhou F, Onizawa S, Nagai A, et al. Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury. Respir Res 2011; 12: 78.
48. Yao H, Chung S, Hwang JW, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 2012; 122: 2032-2045.
49. Bolland S, Garcia-Sastre A. Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice. J Exp Med 2009; 206: 1647-1651.
50. Sethi S. Bacterial infection and the pathogenesis of COPD. Chest 2000; 117: 286S-291S.
51. Lee N, Shin MS, Kang I. T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci 2012; 67: 254-263.
52. Chang CL, Marra G, Chauhan DP, et al. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol 2002; 283: C148-C154.
53. Caramori G, Adcock IM, Casolari P, et al. Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax 2011; 66: 521-527.
54. Ljubuncic P, Reznick AZ. The evolutionary theories of aging revisited - a mini-review. Gerontology 2009; 55: 205-216.
55. Laberge RM, Zhou L, Sarantos MR, et al. Glucocorticoids suppress selected components of the senescenceassociated secretory phenotype. Aging Cell 2012; 11: 569-578.
56. Wistuba II, Lam S, Behrens C, et al. Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst 1997; 89: 1366-1373.
57. Mao L, Lee JS, Kurie JM, et al. Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst 1997; 89: 857-862.