메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 129-136

γH2AX as a molecular marker of aging and disease

Author keywords

Aging; Carcinogenesis; Chromatin modification; DNA damage; Double strand break; Repair; H2AX

Indexed keywords

HISTONE ACETYLTRANSFERASE; BIOLOGICAL MARKER; HISTONE;

EID: 77954022035     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.5.2.11080     Document Type: Review
Times cited : (120)

References (123)
  • 1
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001; 27:247.
    • (2001) Nat Genet , vol.27 , pp. 247
    • Khanna, K.K.1    Jackson, S.P.2
  • 2
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber MR, Ma Y, Pannicke U, Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 2003; 4:712-20.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 3
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks. Cell 2005; 123:1213-26.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 5
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney B, Meek K, Lees-Miller S. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 2009; 417:639-50.
    • (2009) Biochem J , vol.417 , pp. 639-650
    • Mahaney, B.1    Meek, K.2    Lees-Miller, S.3
  • 7
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle. Mol Cell Biol 2003; 23:5706-15.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 8
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 9
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125) IdU-induced DNA double-strand breaks with gamma-H2AX antibody
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125) IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002; 158:486-92.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 12
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 1992; 12:5041-9.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 13
    • 3042805315 scopus 로고    scopus 로고
    • Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions
    • Karlsson K, Stenerlöw B. Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions. Radiat Res 2004; 161:517-27.
    • (2004) Radiat Res , vol.161 , pp. 517-527
    • Karlsson, K.1    Stenerlöw, B.2
  • 14
    • 33645144591 scopus 로고    scopus 로고
    • Induction and quantification of γ-H2AX foci following low and high LET-irradiation
    • Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P. Induction and quantification of γ-H2AX foci following low and high LET-irradiation. Int J Radiat Biol 2006; 82:111-8.
    • (2006) Int J Radiat Biol , vol.82 , pp. 111-118
    • Leatherbarrow, E.L.1    Harper, J.V.2    Cucinotta, F.A.3    O'Neill, P.4
  • 15
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
    • Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA. ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation. Cancer Res 2004; 64:2390-6.
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 16
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434:605-11.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 17
    • 0141757504 scopus 로고    scopus 로고
    • p53 and radiation responses
    • Fei P, El-Deiry WS. p53 and radiation responses. Oncogene 2003; 22:5774-83.
    • (2003) Oncogene , vol.22 , pp. 5774-5783
    • Fei, P.1    El-Deiry, W.S.2
  • 18
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell cycle checkpoint for DNA damage
    • Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, et al. A ribonucleotide reductase gene involved in a p53-dependent cell cycle checkpoint for DNA damage. Nature 2000; 404:42-9.
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3    Shiraishi, K.4    Fukuda, S.5    Matsui, K.6
  • 19
    • 33845715977 scopus 로고    scopus 로고
    • ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    • Stiff T, Walker S, Cerosaletti K, Goodarzi A, Petermann E, Concannon P, et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 2006; 25:5775-82.
    • (2006) EMBO J , vol.25 , pp. 5775-5782
    • Stiff, T.1    Walker, S.2    Cerosaletti, K.3    Goodarzi, A.4    Petermann, E.5    Concannon, P.6
  • 20
    • 1642280957 scopus 로고    scopus 로고
    • UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress
    • Ward IM, Minn K, Chen J. UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress. J Biol Chem 2004; 279:9677-80.
    • (2004) J Biol Chem , vol.279 , pp. 9677-9680
    • Ward, I.M.1    Minn, K.2    Chen, J.3
  • 21
    • 33646769992 scopus 로고    scopus 로고
    • The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage
    • Bouquet F, Muller C, Salles B. The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage. Cell Cycle 2006; 5:1116-22.
    • (2006) Cell Cycle , vol.5 , pp. 1116-1122
    • Bouquet, F.1    Muller, C.2    Salles, B.3
  • 22
    • 4944234150 scopus 로고    scopus 로고
    • Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    • Banath JP, MacPhail SH, Olive PL. Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res 2004; 64:7144-9.
    • (2004) Cancer Res , vol.64 , pp. 7144-7149
    • Banath, J.P.1    MacPhail, S.H.2    Olive, P.L.3
  • 23
    • 10944219768 scopus 로고    scopus 로고
    • Control of sister chromatid recombination by histone H2AX
    • Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing C, et al. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-25.
    • (2004) Mol Cell , vol.16 , pp. 1017-1025
    • Xie, A.1    Puget, N.2    Shim, I.3    Odate, S.4    Jarzyna, I.5    Bassing, C.6
  • 26
    • 40549126605 scopus 로고    scopus 로고
    • Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments
    • Harikrishnan KN, Karagiannis TC, Chow MZ, El-Osta A. Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments. Cell Cycle 2008; 7:468-76.
    • (2008) Cell Cycle , vol.7 , pp. 468-476
    • Harikrishnan, K.N.1    Karagiannis, T.C.2    Chow, M.Z.3    El-Osta, A.4
  • 27
    • 34250015533 scopus 로고    scopus 로고
    • Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments
    • Karagiannis TC, Harikrishnan KN, El-Osta A. Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. Oncogene 2007; 26:3963-71.
    • (2007) Oncogene , vol.26 , pp. 3963-3971
    • Karagiannis, T.C.1    Harikrishnan, K.N.2    El-Osta, A.3
  • 28
    • 55249116558 scopus 로고    scopus 로고
    • Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner A, Wu W, Staudt C, Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucl Acids Res 2008; 36:5678-94.
    • (2008) Nucl Acids Res , vol.36 , pp. 5678-5694
    • Kinner, A.1    Wu, W.2    Staudt, C.3    Iliakis, G.4
  • 29
    • 70249114048 scopus 로고    scopus 로고
    • Microscopic imaging of DNA repair foci in irradiated normal tissues
    • Bhogal N, Jalali F, Bristow RG. Microscopic imaging of DNA repair foci in irradiated normal tissues. Int J Radiat Biol 2009.
    • (2009) Int J Radiat Biol
    • Bhogal, N.1    Jalali, F.2    Bristow, R.G.3
  • 30
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 31
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 2003; 100:5057-62.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 33
    • 0027279628 scopus 로고
    • Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations
    • Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, et al. Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations. N Engl J Med 1993; 329:909-14.
    • (1993) N Engl J Med , vol.329 , pp. 909-914
    • Thirman, M.J.1    Gill, H.J.2    Burnett, R.C.3    Mbangkollo, D.4    McCabe, N.R.5    Kobayashi, H.6
  • 35
    • 0242500374 scopus 로고    scopus 로고
    • Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
    • Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM, et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17:700-6.
    • (2003) Leukemia , vol.17 , pp. 700-706
    • Pui, C.H.1    Chessells, J.M.2    Camitta, B.3    Baruchel, A.4    Biondi, A.5    Boyett, J.M.6
  • 36
    • 0030069762 scopus 로고    scopus 로고
    • 11q23 rearrangements in acute leukemia
    • Rubnitz J, Behm F, Downing J. 11q23 rearrangements in acute leukemia. Leukemia 1996; 10:74-82.
    • (1996) Leukemia , vol.10 , pp. 74-82
    • Rubnitz, J.1    Behm, F.2    Downing, J.3
  • 38
    • 70949093176 scopus 로고    scopus 로고
    • LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer
    • Ong DCT, Ho YM, Rudduck C, Chin K, Kuo WL, Lie DKH, et al. LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. Oncogene 2009; 28:4189-200.
    • (2009) Oncogene , vol.28 , pp. 4189-4200
    • Ong, D.C.T.1    Ho, Y.M.2    Rudduck, C.3    Chin, K.4    Kuo, W.L.5    Lie, D.K.H.6
  • 39
    • 38149028414 scopus 로고    scopus 로고
    • Copy number alterations of the H2AFX gene in sporadic breast cancer patients
    • Srivastava N, Gochhait S, Gupta P, Bamezai R. Copy number alterations of the H2AFX gene in sporadic breast cancer patients. Cancer Genet Cytogenet 2008; 180:121-8.
    • (2008) Cancer Genet Cytogenet , vol.180 , pp. 121-128
    • Srivastava, N.1    Gochhait, S.2    Gupta, P.3    Bamezai, R.4
  • 40
    • 34250358742 scopus 로고    scopus 로고
    • Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma
    • Parikh R, White J, Huang X, Schoppy D, Baysal B, Baskaran R, et al. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer 2007; 46:761-75.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 761-775
    • Parikh, R.1    White, J.2    Huang, X.3    Schoppy, D.4    Baysal, B.5    Baskaran, R.6
  • 41
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3    Kramer, A.4    Tort, F.5    Zieger, K.6
  • 44
    • 0042991379 scopus 로고    scopus 로고
    • Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
    • Bassing C, Suh H, Ferguson D, Chua K, Manis J, Eckersdorff M, et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors Cell 2003; 114:359-70.
    • (2003) Cell , vol.114 , pp. 359-370
    • Bassing, C.1    Suh, H.2    Ferguson, D.3    Chua, K.4    Manis, J.5    Eckersdorff, M.6
  • 46
    • 0037062492 scopus 로고    scopus 로고
    • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
    • Bassing CH. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci USA 2002; 99:8173-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8173-8178
    • Bassing, C.H.1
  • 47
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Nat Acad Sci 2008; 105:9302-6.
    • (2008) Proc Nat Acad Sci , vol.105 , pp. 9302-9306
    • Zha, S.1    Sekiguchi, J.2    Brush, J.W.3    Bassing, C.H.4    Alt, F.W.5
  • 49
    • 0033367088 scopus 로고    scopus 로고
    • The role of genomic instability in human carcinogenesis
    • Coleman W, Tsongalis G. The role of genomic instability in human carcinogenesis. Anticancer Res 1999; 19:4645-64.
    • (1999) Anticancer Res , vol.19 , pp. 4645-4664
    • Coleman, W.1    Tsongalis, G.2
  • 50
    • 68449090353 scopus 로고    scopus 로고
    • Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells
    • Nakamura A, Redon C, Sedelnikova O. Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells. Cell Cycle 2009; 8:2324.
    • (2009) Cell Cycle , vol.8 , pp. 2324
    • Nakamura, A.1    Redon, C.2    Sedelnikova, O.3
  • 51
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • Yu T, MacPhail SH, Banath JP, Klokov D, Olive PL. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair 2006; 5:935-46.
    • (2006) DNA Repair , vol.5 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3    Klokov, D.4    Olive, P.L.5
  • 52
    • 16844370883 scopus 로고    scopus 로고
    • Melanoma Cells Express Elevated Levels of Phosphorylated Histone H2AX Foci
    • Warters RL, Adamson PJ, Pond CD, Leachman SA. Melanoma Cells Express Elevated Levels of Phosphorylated Histone H2AX Foci. J Investig Dermatol 2005; 124:807-17.
    • (2005) J Investig Dermatol , vol.124 , pp. 807-817
    • Warters, R.L.1    Adamson, P.J.2    Pond, C.D.3    Leachman, S.A.4
  • 53
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13:1549-56.
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 55
    • 33845651212 scopus 로고    scopus 로고
    • Gamma H2AX in cancer cells: A potential biomarker for cancer diagnostics, prediction and recurrence
    • Sedelnikova OA, Bonner WM. gamma H2AX in cancer cells: A potential biomarker for cancer diagnostics, prediction and recurrence. Cell Cycle 2006; 5:2909-13.
    • (2006) Cell Cycle , vol.5 , pp. 2909-2913
    • Sedelnikova, O.A.1    Bonner, W.M.2
  • 56
    • 45449083227 scopus 로고    scopus 로고
    • DNA double-strand breaks: A potential causative factor for mammalian aging?
    • Li H, Mitchell J, Hasty P. DNA double-strand breaks: a potential causative factor for mammalian aging?. Mech Ageing Dev 2008; 129:416-24.
    • (2008) Mech Ageing Dev , vol.129 , pp. 416-424
    • Li, H.1    Mitchell, J.2    Hasty, P.3
  • 58
    • 66049160126 scopus 로고    scopus 로고
    • The ageing epigenome: Damaged beyond repair?
    • Sinclair DA, Oberdoerffer P. The ageing epigenome: Damaged beyond repair? Ageing Res Rev 2009; 8:189-98.
    • (2009) Ageing Res Rev , vol.8 , pp. 189-198
    • Sinclair, D.A.1    Oberdoerffer, P.2
  • 59
    • 21344440000 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of cellular senescence
    • Colavitti R, Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB Life 2005; 57:277-81.
    • (2005) IUBMB Life , vol.57 , pp. 277-281
    • Colavitti, R.1    Finkel, T.2
  • 64
    • 2542536710 scopus 로고    scopus 로고
    • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells
    • Bakkenist CJ, Drissi R, Wu J, Kastan MB, Dome JS. Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells. Cancer Res 2004; 64:3748-52.
    • (2004) Cancer Res , vol.64 , pp. 3748-3752
    • Bakkenist, C.J.1    Drissi, R.2    Wu, J.3    Kastan, M.B.4    Dome, J.S.5
  • 66
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: Ageing, cancer and beyond
    • Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 2005; 6:611-22.
    • (2005) Nat Rev Genet , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 67
    • 0037012028 scopus 로고    scopus 로고
    • A model for the phenotypic presentation of Werner's syndrome
    • Ostler E, Wallis C, Sheerin A, Faragher R. A model for the phenotypic presentation of Werner's syndrome. Exp Gerontol 2002; 37:285-92.
    • (2002) Exp Gerontol , vol.37 , pp. 285-292
    • Ostler, E.1    Wallis, C.2    Sheerin, A.3    Faragher, R.4
  • 68
    • 24044441918 scopus 로고    scopus 로고
    • Deficient DNA repair in the human progeroid disorder, Werner syndrome
    • Bohr V. Deficient DNA repair in the human progeroid disorder, Werner syndrome. Mutat Res 2005; 577:252-9.
    • (2005) Mutat Res , vol.577 , pp. 252-259
    • Bohr, V.1
  • 69
    • 18844457575 scopus 로고    scopus 로고
    • Making ends meet in old age: DSB repair and aging
    • Gorbunova V, Seluanov A. Making ends meet in old age: DSB repair and aging. Mech Ageing Dev 2005; 126:621-8.
    • (2005) Mech Ageing Dev , vol.126 , pp. 621-628
    • Gorbunova, V.1    Seluanov, A.2
  • 70
    • 35748930210 scopus 로고    scopus 로고
    • Changes in the level and distribution of Ku proteins during cellular senescence
    • Seluanov A, Danek J, Hause N, Gorbunova V. Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair 2007; 6:1740-8.
    • (2007) DNA Repair , vol.6 , pp. 1740-1748
    • Seluanov, A.1    Danek, J.2    Hause, N.3    Gorbunova, V.4
  • 71
    • 33947301294 scopus 로고    scopus 로고
    • Immune dysfunction in inflammatory bowel disease
    • Neuman MG. Immune dysfunction in inflammatory bowel disease. Transl Res 2007; 149:173-86.
    • (2007) Transl Res , vol.149 , pp. 173-186
    • Neuman, M.G.1
  • 72
    • 79961129896 scopus 로고    scopus 로고
    • Gatekeepers of intestinal inflammation
    • Epub ahead of print
    • Arnett H, Viney J. Gatekeepers of intestinal inflammation. Inflamm Res 2009; Epub ahead of print.
    • (2009) Inflamm Res
    • Arnett, H.1    Viney, J.2
  • 73
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 2007; 117:514-21.
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 74
    • 0032121445 scopus 로고    scopus 로고
    • Nitric oxide and oxygen radicals in infection, inflammation and cancer
    • Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflammation and cancer. Biochemistry 1998; 63:854-65.
    • (1998) Biochemistry , vol.63 , pp. 854-865
    • Maeda, H.1    Akaike, T.2
  • 75
    • 19744364192 scopus 로고    scopus 로고
    • Persistence of inflammatory cytokines cause a spectrum of chronic progressive diseases: Implications for therapy
    • Forrester J, Bick-Forrester J. Persistence of inflammatory cytokines cause a spectrum of chronic progressive diseases: implications for therapy. Med Hypotheses 2005; 65:227-31.
    • (2005) Med Hypotheses , vol.65 , pp. 227-231
    • Forrester, J.1    Bick-Forrester, J.2
  • 76
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis
    • Galkina E, Ley K. Immune and Inflammatory Mechanisms of Atherosclerosis*. Annu Rev Immunol 2009; 27:165-97.
    • (2009) Annu Rev Immunol , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 77
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000; 21:361-70.
    • (2000) Carcinogenesis , vol.21 , pp. 361-370
    • Marnett, L.J.1
  • 78
    • 66149137964 scopus 로고    scopus 로고
    • Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication
    • Nichols GJ, Schaack J, Ornelles DA. Widespread Phosphorylation of Histone H2AX by Species C Adenovirus Infection Requires Viral DNA Replication. J Virol 2009; 83:5987-98.
    • (2009) J Virol , vol.83 , pp. 5987-5998
    • Nichols, G.J.1    Schaack, J.2    Ornelles, D.A.3
  • 79
    • 77951254355 scopus 로고    scopus 로고
    • The Role of inflammation in the pathogenesis of colorectal cancer
    • McConnell B, Yang V. The Role of Inflammation in the Pathogenesis of Colorectal Cancer. Curr Colorectal Cancer Rep 2009; 5:69-74.
    • (2009) Curr Colorectal Cancer Rep , vol.5 , pp. 69-74
    • McConnell, B.1    Yang, V.2
  • 80
    • 48549086606 scopus 로고    scopus 로고
    • Ulcerative colitis is a disease of accelerated colon aging: Evidence from telomere attrition and DNA damage
    • Risques RA, Lai LA, Brentnall TA, Li L, Feng Z, Gallaher J, et al. Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA Damage. Gastroenterology 2008; 135:410-8.
    • (2008) Gastroenterology , vol.135 , pp. 410-418
    • Risques, R.A.1    Lai, L.A.2    Brentnall, T.A.3    Li, L.4    Feng, Z.5    Gallaher, J.6
  • 81
    • 0037331882 scopus 로고    scopus 로고
    • DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free
    • Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Koprowicz KM, Bronner MP, Brentnall TA. DNA Fingerprinting Abnormalities Can Distinguish Ulcerative Colitis Patients with Dysplasia and Cancer from Those Who Are Dysplasia/Cancer-Free. Am J Pathol 2003; 162:665-72.
    • (2003) Am J Pathol , vol.162 , pp. 665-672
    • Chen, R.1    Rabinovitch, P.S.2    Crispin, D.A.3    Emond, M.J.4    Koprowicz, K.M.5    Bronner, M.P.6    Brentnall, T.A.7
  • 82
    • 0037357426 scopus 로고    scopus 로고
    • Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models
    • Seril DN, Liao J, Yang G-Y, Yang CS. Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 2003; 24:353-62.
    • (2003) Carcinogenesis , vol.24 , pp. 353-362
    • Seril, D.N.1    Liao, J.2    Yang, G-Y.3    Yang, C.S.4
  • 83
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420:860-7.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 84
    • 35448989663 scopus 로고    scopus 로고
    • Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway
    • Blanco D, Vicent S, Fraga M, Fernandez-Garcia I, Freire J, Lujambio A, et al. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia 2007; 9:840-52.
    • (2007) Neoplasia , vol.9 , pp. 840-852
    • Blanco, D.1    Vicent, S.2    Fraga, M.3    Fernandez-Garcia, I.4    Freire, J.5    Lujambio, A.6
  • 86
    • 0037206597 scopus 로고    scopus 로고
    • Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles
    • Nagasawa H, Little J. Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutat Res 2002; 508:121-9.
    • (2002) Mutat Res , vol.508 , pp. 121-129
    • Nagasawa, H.1    Little, J.2
  • 87
    • 0142061531 scopus 로고    scopus 로고
    • A review of the bystander effect and its implications for low-dose exposure
    • Prise KM, Folkard M, Michael BB. A review of the bystander effect and its implications for low-dose exposure. Radiat Prot Dosimetry 2003; 104:347-55.
    • (2003) Radiat Prot Dosimetry , vol.104 , pp. 347-355
    • Prise, K.M.1    Folkard, M.2    Michael, B.B.3
  • 88
    • 33646052257 scopus 로고    scopus 로고
    • Cellular radiation effects and the bystander response
    • Little J. Cellular radiation effects and the bystander response. Mutat Res 2006; 597:113-8.
    • (2006) Mutat Res , vol.597 , pp. 113-118
    • Little, J.1
  • 90
    • 33847024239 scopus 로고    scopus 로고
    • ATR-dependent radiation-induced [gamma]H2AX foci in bystander primary human astrocytes and glioma cells
    • Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM. ATR-dependent radiation-induced [gamma]H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 2006; 26:993-1002.
    • (2006) Oncogene , vol.26 , pp. 993-1002
    • Burdak-Rothkamm, S.1    Short, S.C.2    Folkard, M.3    Rothkamm, K.4    Prise, K.M.5
  • 91
    • 34347371622 scopus 로고    scopus 로고
    • A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts
    • Smilenov LB, Hall EJ, Bonner WM, Sedelnikova OA. A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts. Radiat Prot Dosimetry. 2006; 122:256-9.
    • (2006) Radiat Prot Dosimetry , vol.122 , pp. 256-259
    • Smilenov, L.B.1    Hall, E.J.2    Bonner, W.M.3    Sedelnikova, O.A.4
  • 92
    • 35148834590 scopus 로고    scopus 로고
    • Gamma-H2AX in bystander cells-Not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication
    • Sokolov MV, Dickey JS, Bonner WM, Sedelnikova OA. gamma-H2AX in bystander cells-Not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle 2007; 6:2210-2.
    • (2007) Cell Cycle , vol.6 , pp. 2210-2212
    • Sokolov, M.V.1    Dickey, J.S.2    Bonner, W.M.3    Sedelnikova, O.A.4
  • 93
    • 31544478262 scopus 로고    scopus 로고
    • The time and spatial effects of bystander response in mammalian cells induced by low dose radiation
    • Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, et al. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 2006; 27:245-51.
    • (2006) Carcinogenesis , vol.27 , pp. 245-251
    • Hu, B.1    Wu, L.2    Han, W.3    Zhang, L.4    Chen, S.5    Xu, A.6
  • 96
    • 0037317216 scopus 로고    scopus 로고
    • Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors
    • Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, et al. Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Int J Radiat Biol 2003; 79:129-36.
    • (2003) Int J Radiat Biol , vol.79 , pp. 129-136
    • Hayashi, T.1    Kusunoki, Y.2    Hakoda, M.3    Morishita, Y.4    Kubo, Y.5    Maki, M.6
  • 97
    • 0035075485 scopus 로고    scopus 로고
    • Persistent subclinical inflammation among A-bomb survivors
    • Neriishi K, Nakashima E, Delongchamp R. Persistent subclinical inflammation among A-bomb survivors. Int J Radiat Biol 2001; 77:475-82.
    • (2001) Int J Radiat Biol , vol.77 , pp. 475-482
    • Neriishi, K.1    Nakashima, E.2    Delongchamp, R.3
  • 99
    • 34147190372 scopus 로고    scopus 로고
    • Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells
    • Han W, Wu L, Chen S, Bao L, Zhang L, Jiang E, et al. Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells. Oncogene 2007; 26:2330-9.
    • (2007) Oncogene , vol.26 , pp. 2330-2339
    • Han, W.1    Wu, L.2    Chen, S.3    Bao, L.4    Zhang, L.5    Jiang, E.6
  • 102
    • 30444459031 scopus 로고    scopus 로고
    • The role of inflammation in CNS injury and disease
    • Lucas S-M, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol 2006; 147:232-40.
    • (2006) Br J Pharmacol , vol.147 , pp. 232-240
    • Lucas, S-M.1    Rothwell, N.J.2    Gibson, R.M.3
  • 103
    • 0033979993 scopus 로고    scopus 로고
    • Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
    • del Zoppo G, Ginis I, Hallenbeck M, Iadecola C, Wang X, Feuerstein G. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 2000; 10:95-112.
    • (2000) Brain Pathol , vol.10 , pp. 95-112
    • del Zoppo, G.1    Ginis, I.2    Hallenbeck, M.3    Iadecola, C.4    Wang, X.5    Feuerstein, G.6
  • 104
    • 0036949091 scopus 로고    scopus 로고
    • Local Neuroinflammation and the Progression of Alzheimer's Disease
    • McGeer PL, McGeer EG. Local Neuroinflammation and the Progression of Alzheimer's Disease. J Neurovirol 2002; 8:529-38.
    • (2002) J Neurovirol , vol.8 , pp. 529-538
    • McGeer, P.L.1    McGeer, E.G.2
  • 105
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch U. Microglia as a source and target of cytokines. Glia 2002; 40:140-55.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.1
  • 106
    • 77955832762 scopus 로고    scopus 로고
    • Inflammation in ischemic brain injury: Current advances and future perspectives
    • In press
    • Xia W, Han J, Huang G, Ying W. Inflammation in Ischemic Brain Injury: Current Advances and Future Perspectives. Clin Exp Pharmacol Physiol 2009; In press.
    • (2009) Clin Exp Pharmacol Physiol
    • Xia, W.1    Han, J.2    Huang, G.3    Ying, W.4
  • 107
    • 34047156083 scopus 로고    scopus 로고
    • TGF{beta} and atherosclerosis in man
    • Grainger DJ. TGF{beta} and atherosclerosis in man. Cardiovasc Res 2007; 74:213-22.
    • (2007) Cardiovasc Res , vol.74 , pp. 213-222
    • Grainger, D.J.1
  • 108
    • 0034083227 scopus 로고    scopus 로고
    • Role of oxidative stress in cardiovascular diseases
    • Dhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens 2000; 18:655-73.
    • (2000) J Hypertens , vol.18 , pp. 655-673
    • Dhalla, N.S.1    Temsah, R.M.2    Netticadan, T.3
  • 109
    • 0032989441 scopus 로고    scopus 로고
    • Evidence for the role of oxidative stress in acute ischemic heart disease: A brief review
    • Dhalla N, Golfman L, Takeda S, Takeda N, Nagano M. Evidence for the role of oxidative stress in acute ischemic heart disease: a brief review. Can J Cardiol 1999; 15:587-93.
    • (1999) Can J Cardiol , vol.15 , pp. 587-593
    • Dhalla, N.1    Golfman, L.2    Takeda, S.3    Takeda, N.4    Nagano, M.5
  • 110
    • 0022336547 scopus 로고
    • Mechanisms of lipid peroxidation
    • Girotti A. Mechanisms of lipid peroxidation. J Free Radic Biol Med 1985; 1:87-95.
    • (1985) J Free Radic Biol Med , vol.1 , pp. 87-95
    • Girotti, A.1
  • 111
    • 0030988742 scopus 로고    scopus 로고
    • Biochemistry and pathology of radical-mediated protein oxidation
    • Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997; 324:1-18.
    • (1997) Biochem J , vol.324 , pp. 1-18
    • Dean, R.T.1    Fu, S.2    Stocker, R.3    Davies, M.J.4
  • 113
    • 33644782017 scopus 로고    scopus 로고
    • New Cellular and Molecular Immune Pathways in Ischemia/Reperfusion Injury
    • Boros P, Bromberg JS. New Cellular and Molecular Immune Pathways in Ischemia/Reperfusion Injury. Am J Transplantation 2006; 6:652-8.
    • (2006) Am J Transplantation , vol.6 , pp. 652-658
    • Boros, P.1    Bromberg, J.S.2
  • 114
    • 56249126783 scopus 로고    scopus 로고
    • Lymphocytes and ischemia-reperfusion injury
    • Linfert D, Chowdhry T, Rabb H. Lymphocytes and ischemia-reperfusion injury. Transplant Rev 2009; 23:1-10.
    • (2009) Transplant Rev , vol.23 , pp. 1-10
    • Linfert, D.1    Chowdhry, T.2    Rabb, H.3
  • 115
    • 0037261536 scopus 로고    scopus 로고
    • Ischemia-reperfusion-related repair deficit after oxidative stress: Implications of faulty transcripts in neuronal sensitivity after brain injury
    • Liu P. Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury. J Biomed Sci 2003; 10:4-13.
    • (2003) J Biomed Sci , vol.10 , pp. 4-13
    • Liu, P.1
  • 117
    • 34548583437 scopus 로고    scopus 로고
    • Innate immunity, macrophage activation and atherosclerosis
    • Yan Z, Hansson G. Innate immunity, macrophage activation and atherosclerosis. Immunol Rev 2007; 219:187-203.
    • (2007) Immunol Rev , vol.219 , pp. 187-203
    • Yan, Z.1    Hansson, G.2
  • 118
    • 61649115400 scopus 로고    scopus 로고
    • Oxidative stress in environmental-induced carcinogenesis
    • Mena S, Ortega A, Estrela J. Oxidative stress in environmental-induced carcinogenesis. Mutat Res 2009; 674:36-44.
    • (2009) Mutat Res , vol.674 , pp. 36-44
    • Mena, S.1    Ortega, A.2    Estrela, J.3
  • 120
    • 85047679198 scopus 로고
    • The oxygen free radical system: From equations through membrane-protein interactions to cardiovascular injury and protection
    • Kukreja RC, Hess ML. The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res 1992; 26:641-55.
    • (1992) Cardiovasc Res , vol.26 , pp. 641-655
    • Kukreja, R.C.1    Hess, M.L.2
  • 121
    • 0035090023 scopus 로고    scopus 로고
    • General aspects of the cellular response to low- and high-LET radiation
    • Pouget J-P, Mather SJ. General aspects of the cellular response to low- and high-LET radiation. Eur J Nucl Med 2001; 28:541-61.
    • (2001) Eur J Nucl Med , vol.28 , pp. 541-561
    • Pouget, J-P.1    Mather, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.