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Volumn 41, Issue 21, 2013, Pages

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

(22)  Börner, Kathleen a   Niopek, Dominik a,b   Cotugno, Gabriella a,b,e   Kaldenbach, Michaela c   Pankert, Teresa a,b,d   Willemsen, Joschka b   Zhang, Xian d   Schürmann, Nina a,b   Mockenhaupt, Stefan a,b,h   Serva, Andrius b,d   Hiet, Marie Sophie b   Wiedtke, Ellen a,b   Castoldi, Mirco a,g   Starkuviene, Vytaute b   Erfle, Holger b   Gilbert, Daniel F d,f   Bartenschlager, Ralf b   Boutros, Michael b,d   Binder, Marco b   Streetz, Konrad c   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 2 PROTEIN; COMPLEMENTARY DNA; LENTIVIRUS VECTOR; MESSENGER RNA; SHORT HAIRPIN RNA; VIRUS VECTOR;

EID: 84890012407     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt836     Document Type: Article
Times cited : (50)

References (79)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D. and Rossi, J.J. (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature, 457, 426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 4
    • 84862217953 scopus 로고    scopus 로고
    • The dose can make the poison: Lessons learned from adverse in vivo toxicities caused by RNAi overexpression
    • Grimm, D. (2011) The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression. Silence, 2, 8.
    • (2011) Silence , vol.2 , pp. 8
    • Grimm, D.1
  • 5
    • 77949446144 scopus 로고    scopus 로고
    • Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system
    • Ehlert, E.M., Eggers, R., Niclou, S.P. and Verhaagen, J. (2010) Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system. BMC Neurosci., 11, 20.
    • (2010) BMC Neurosci. , vol.11 , pp. 20
    • Ehlert, E.M.1    Eggers, R.2    Niclou, S.P.3    Verhaagen, J.4
  • 6
    • 80051978446 scopus 로고    scopus 로고
    • Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines
    • Bish, L.T., Sleeper, M.M., Reynolds, C., Gazzara, J., Withnall, E., Singletary, G.E., Buchlis, G., Hui, D., High, K.A., Gao, G. et al. (2011) Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines. Hum. Gene Ther., 22, 969-977.
    • (2011) Hum. Gene Ther. , vol.22 , pp. 969-977
    • Bish, L.T.1    Sleeper, M.M.2    Reynolds, C.3    Gazzara, J.4    Withnall, E.5    Singletary, G.E.6    Buchlis, G.7    Hui, D.8    High, K.A.9    Gao, G.10
  • 7
    • 69949144286 scopus 로고    scopus 로고
    • Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
    • Ulusoy, A., Sahin, G., Bjorklund, T., Aebischer, P. and Kirik, D. (2009) Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. Mol. Ther., 17, 1574-1584.
    • (2009) Mol. Ther. , vol.17 , pp. 1574-1584
    • Ulusoy, A.1    Sahin, G.2    Bjorklund, T.3    Aebischer, P.4    Kirik, D.5
  • 8
    • 79960148982 scopus 로고    scopus 로고
    • Lethal toxicity caused by expression of shRNA in the mouse striatum: Implications for therapeutic design
    • Martin, J.N., Wolken, N., Brown, T., Dauer, W.T., Ehrlich, M.E. and Gonzalez-Alegre, P. (2011) Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Ther., 18, 666-673.
    • (2011) Gene Ther. , vol.18 , pp. 666-673
    • Martin, J.N.1    Wolken, N.2    Brown, T.3    Dauer, W.T.4    Ehrlich, M.E.5    Gonzalez-Alegre, P.6
  • 9
    • 79957923807 scopus 로고    scopus 로고
    • An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
    • Khodr, C.E., Sapru, M.K., Pedapati, J., Han, Y., West, N.C., Kells, A.P., Bankiewicz, K.S. and Bohn, M.C. (2011) An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons. Brain Res., 1395, 94-107.
    • (2011) Brain Res. , vol.1395 , pp. 94-107
    • Khodr, C.E.1    Sapru, M.K.2    Pedapati, J.3    Han, Y.4    West, N.C.5    Kells, A.P.6    Bankiewicz, K.S.7    Bohn, M.C.8
  • 11
    • 36148972467 scopus 로고    scopus 로고
    • Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
    • Vickers, T.A., Lima, W.F., Nichols, J.G. and Crooke, S.T. (2007) Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic Acids Res., 35, 6598-6610.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 6598-6610
    • Vickers, T.A.1    Lima, W.F.2    Nichols, J.G.3    Crooke, S.T.4
  • 13
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • Khan, A.A., Betel, D., Miller, M.L., Sander, C., Leslie, C.S. and Marks, D.S. (2009) Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol., 27, 549-555.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 14
    • 79953236944 scopus 로고    scopus 로고
    • Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection
    • Pan, Q., de Ruiter, P.E., von Eije, K.J., Smits, R., Kwekkeboom, J., Tilanus, H.W., Berkhout, B., Janssen, H.L. and van der Laan, L.J. (2011) Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection. FEBS Lett., 585, 1025-1030.
    • (2011) FEBS Lett. , vol.585 , pp. 1025-1030
    • Pan, Q.1    De Ruiter, P.E.2    Von Eije, K.J.3    Smits, R.4    Kwekkeboom, J.5    Tilanus, H.W.6    Berkhout, B.7    Janssen, H.L.8    Van Der Laan, L.J.9
  • 15
    • 78649907430 scopus 로고    scopus 로고
    • Use of small RNAs for therapeutic gene silencing: Risk versus benefit
    • Börner, K. and Grimm, D. (2010) Use of small RNAs for therapeutic gene silencing: risk versus benefit. Drug Disc. Today Technol., 7, e51-e57.
    • (2010) Drug Disc. Today Technol. , vol.7
    • Börner, K.1    Grimm, D.2
  • 17
    • 77956355233 scopus 로고    scopus 로고
    • Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
    • Grimm, D., Wang, L., Lee, J.S., Schurmann, N., Gu, S., Borner, K., Storm, T.A. and Kay, M.A. (2010) Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. J. Clin. Invest., 120, 3106-3119.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3106-3119
    • Grimm, D.1    Wang, L.2    Lee, J.S.3    Schurmann, N.4    Gu, S.5    Borner, K.6    Storm, T.A.7    Kay, M.A.8
  • 18
    • 12844285548 scopus 로고    scopus 로고
    • Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
    • Yi, R., Doehle, B.P., Qin, Y., Macara, I.G. and Cullen, B.R. (2005) Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA, 11, 220-226.
    • (2005) RNA , vol.11 , pp. 220-226
    • Yi, R.1    Doehle, B.P.2    Qin, Y.3    Macara, I.G.4    Cullen, B.R.5
  • 19
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi, R., Qin, Y., Macara, I.G. and Cullen, B.R. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev., 17, 3011-3016.
    • (2003) Genes Dev. , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 20
    • 33644992707 scopus 로고    scopus 로고
    • In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5
    • Ohrt, T., Merkle, D., Birkenfeld, K., Echeverri, C.J. and Schwille, P. (2006) In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5. Nucleic Acids Res., 34, 1369-1380.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 1369-1380
    • Ohrt, T.1    Merkle, D.2    Birkenfeld, K.3    Echeverri, C.J.4    Schwille, P.5
  • 21
    • 0041691111 scopus 로고    scopus 로고
    • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
    • Zeng, Y., Yi, R. and Cullen, B.R. (2003) MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA, 100, 9779-9784.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 9779-9784
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 22
    • 43549096196 scopus 로고    scopus 로고
    • The Argonaute protein family
    • Hock, J. and Meister, G. (2008) The Argonaute protein family. Genome Biol., 9, 210.
    • (2008) Genome Biol. , vol.9 , pp. 210
    • Hock, J.1    Meister, G.2
  • 26
    • 36849048778 scopus 로고    scopus 로고
    • Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
    • Diederichs, S. and Haber, D.A. (2007) Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell, 131, 1097-1108.
    • (2007) Cell , vol.131 , pp. 1097-1108
    • Diederichs, S.1    Haber, D.A.2
  • 27
    • 81255176919 scopus 로고    scopus 로고
    • Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
    • Winter, J. and Diederichs, S. (2011) Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol., 8, 1149-1157.
    • (2011) RNA Biol. , vol.8 , pp. 1149-1157
    • Winter, J.1    Diederichs, S.2
  • 28
    • 77953183812 scopus 로고    scopus 로고
    • A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    • Cheloufi, S., Dos Santos, C.O., Chong, M.M. and Hannon, G.J. (2010) A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature, 465, 584-589.
    • (2010) Nature , vol.465 , pp. 584-589
    • Cheloufi, S.1    Dos Santos, C.O.2    Chong, M.M.3    Hannon, G.J.4
  • 31
    • 79959366354 scopus 로고    scopus 로고
    • Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes
    • Gu, S., Jin, L., Zhang, F., Huang, Y., Grimm, D., Rossi, J.J. and Kay, M.A. (2011) Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proc. Natl Acad. Sci. USA, 108, 9208-9213.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9208-9213
    • Gu, S.1    Jin, L.2    Zhang, F.3    Huang, Y.4    Grimm, D.5    Rossi, J.J.6    Kay, M.A.7
  • 32
    • 79953020954 scopus 로고    scopus 로고
    • Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects
    • Petri, S., Dueck, A., Lehmann, G., Putz, N., Rudel, S., Kremmer, E. and Meister, G. (2011) Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects. RNA, 17, 737-749.
    • (2011) RNA , vol.17 , pp. 737-749
    • Petri, S.1    Dueck, A.2    Lehmann, G.3    Putz, N.4    Rudel, S.5    Kremmer, E.6    Meister, G.7
  • 33
    • 84876030403 scopus 로고    scopus 로고
    • Dicerindependent processing of short hairpin RNAs
    • Liu, Y.P., Schopman, N.C. and Berkhout, B. (2013) Dicerindependent processing of short hairpin RNAs. Nucleic Acids Res., 41, 3723-3733.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 3723-3733
    • Liu, Y.P.1    Schopman, N.C.2    Berkhout, B.3
  • 34
    • 0026506252 scopus 로고
    • A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication
    • Charneau, P., Alizon, M. and Clavel, F. (1992) A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication. J. Virol., 66, 2814-2820.
    • (1992) J. Virol. , vol.66 , pp. 2814-2820
    • Charneau, P.1    Alizon, M.2    Clavel, F.3
  • 37
    • 0023216839 scopus 로고
    • A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication
    • Samulski, R.J., Chang, L.S. and Shenk, T. (1987) A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J. Virol., 61, 3096-3101.
    • (1987) J. Virol. , vol.61 , pp. 3096-3101
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 38
  • 39
    • 33646743366 scopus 로고    scopus 로고
    • Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses
    • Koutsoudakis, G., Kaul, A., Steinmann, E., Kallis, S., Lohmann, V., Pietschmann, T. and Bartenschlager, R. (2006) Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J. Virol., 80, 5308-5320.
    • (2006) J. Virol. , vol.80 , pp. 5308-5320
    • Koutsoudakis, G.1    Kaul, A.2    Steinmann, E.3    Kallis, S.4    Lohmann, V.5    Pietschmann, T.6    Bartenschlager, R.7
  • 40
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey, R., Nagy, D., Mandel, R.J., Naldini, L. and Trono, D. (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol., 15, 871-875.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 41
    • 0036430191 scopus 로고    scopus 로고
    • Production methods for gene transfer vectors based on adeno-associated virus serotypes
    • Grimm, D. (2002) Production methods for gene transfer vectors based on adeno-associated virus serotypes. Methods, 28, 146-157.
    • (2002) Methods , vol.28 , pp. 146-157
    • Grimm, D.1
  • 42
    • 39449096929 scopus 로고    scopus 로고
    • MiChip: An array-based method for microRNA expression profiling using locked nucleic acid capture probes
    • Castoldi, M., Schmidt, S., Benes, V., Hentze, M.W. and Muckenthaler, M.U. (2008) miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat. Protoc., 3, 321-329.
    • (2008) Nat. Protoc. , vol.3 , pp. 321-329
    • Castoldi, M.1    Schmidt, S.2    Benes, V.3    Hentze, M.W.4    Muckenthaler, M.U.5
  • 43
    • 33646178285 scopus 로고    scopus 로고
    • A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)
    • Castoldi, M., Schmidt, S., Benes, V., Noerholm, M., Kulozik, A.E., Hentze, M.W. and Muckenthaler, M.U. (2006) A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA, 12, 913-920.
    • (2006) RNA , vol.12 , pp. 913-920
    • Castoldi, M.1    Schmidt, S.2    Benes, V.3    Noerholm, M.4    Kulozik, A.E.5    Hentze, M.W.6    Muckenthaler, M.U.7
  • 44
    • 0035147424 scopus 로고    scopus 로고
    • Multicolour imaging of post-Golgi sorting and trafficking in live cells
    • Keller, P., Toomre, D., Diaz, E., White, J. and Simons, K. (2001) Multicolour imaging of post-Golgi sorting and trafficking in live cells. Nat. Cell Biol., 3, 140-149.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 140-149
    • Keller, P.1    Toomre, D.2    Diaz, E.3    White, J.4    Simons, K.5
  • 47
    • 77951959633 scopus 로고    scopus 로고
    • EBImage-an R package for image processing with applications to cellular phenotypes
    • Pau, G., Fuchs, F., Sklyar, O., Boutros, M. and Huber, W. (2010) EBImage-an R package for image processing with applications to cellular phenotypes. Bioinformatics, 26, 979-981.
    • (2010) Bioinformatics , vol.26 , pp. 979-981
    • Pau, G.1    Fuchs, F.2    Sklyar, O.3    Boutros, M.4    Huber, W.5
  • 49
    • 49249126411 scopus 로고    scopus 로고
    • Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates
    • Erfle, H., Neumann, B., Rogers, P., Bulkescher, J., Ellenberg, J. and Pepperkok, R. (2008) Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates. J. Biomol. Screen., 13, 575-580.
    • (2008) J. Biomol. Screen. , vol.13 , pp. 575-580
    • Erfle, H.1    Neumann, B.2    Rogers, P.3    Bulkescher, J.4    Ellenberg, J.5    Pepperkok, R.6
  • 50
    • 0031716336 scopus 로고    scopus 로고
    • Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: Analysis of its role in enhancement of viral infectivity
    • Welker, R., Harris, M., Cardel, B. and Krausslich, H.G. (1998) Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. J. Virol., 72, 8833-8840.
    • (1998) J. Virol. , vol.72 , pp. 8833-8840
    • Welker, R.1    Harris, M.2    Cardel, B.3    Krausslich, H.G.4
  • 51
    • 61449164033 scopus 로고    scopus 로고
    • RNAither, an automated pipeline for the statistical analysis of highthroughput RNAi screens
    • Rieber, N., Knapp, B., Eils, R. and Kaderali, L. (2009) RNAither, an automated pipeline for the statistical analysis of highthroughput RNAi screens. Bioinformatics, 25, 678-679.
    • (2009) Bioinformatics , vol.25 , pp. 678-679
    • Rieber, N.1    Knapp, B.2    Eils, R.3    Kaderali, L.4
  • 52
  • 53
    • 1542369977 scopus 로고    scopus 로고
    • From virus evolution to vector revolution: Use of naturally occurring serotypes of adenoassociated virus (AAV) as novel vectors for human gene therapy
    • Grimm, D. and Kay, M.A. (2003) From virus evolution to vector revolution: use of naturally occurring serotypes of adenoassociated virus (AAV) as novel vectors for human gene therapy. Curr. Gene Ther., 3, 281-304.
    • (2003) Curr. Gene Ther. , vol.3 , pp. 281-304
    • Grimm, D.1    Kay, M.A.2
  • 54
    • 44949131860 scopus 로고    scopus 로고
    • In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
    • Grimm, D., Lee, J.S., Wang, L., Desai, T., Akache, B., Storm, T.A. and Kay, M.A. (2008) In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J. Virol., 82, 5887-5911.
    • (2008) J. Virol. , vol.82 , pp. 5887-5911
    • Grimm, D.1    Lee, J.S.2    Wang, L.3    Desai, T.4    Akache, B.5    Storm, T.A.6    Kay, M.A.7
  • 55
    • 0034882826 scopus 로고    scopus 로고
    • Selfcomplementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
    • McCarty, D.M., Monahan, P.E. and Samulski, R.J. (2001) Selfcomplementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther., 8, 1248-1254.
    • (2001) Gene Ther. , vol.8 , pp. 1248-1254
    • McCarty, D.M.1    Monahan, P.E.2    Samulski, R.J.3
  • 56
    • 67749129050 scopus 로고    scopus 로고
    • Asymmetry in siRNA design
    • Grimm, D. (2009) Asymmetry in siRNA design. Gene Ther., 16, 827-829.
    • (2009) Gene Ther. , vol.16 , pp. 827-829
    • Grimm, D.1
  • 58
    • 53349168896 scopus 로고    scopus 로고
    • Enhancement of RNAi by a small molecule antibiotic enoxacin
    • Zhang, Q., Zhang, C. and Xi, Z. (2008) Enhancement of RNAi by a small molecule antibiotic enoxacin. Cell Res., 18, 1077-1079.
    • (2008) Cell Res. , vol.18 , pp. 1077-1079
    • Zhang, Q.1    Zhang, C.2    Xi, Z.3
  • 59
    • 77449141681 scopus 로고    scopus 로고
    • Small molecule modifiers of the microRNA and RNA interference pathway
    • Deiters, A. (2010) Small molecule modifiers of the microRNA and RNA interference pathway. AAPS J., 12, 51-60.
    • (2010) AAPS J. , vol.12 , pp. 51-60
    • Deiters, A.1
  • 60
    • 79959253434 scopus 로고    scopus 로고
    • Co-expression of Argonaute2 enhances short hairpin RNAinduced RNA interference in Xenopus CNS neurons in vivo
    • Chen, C.M., Chiu, S.L., Shen, W. and Cline, H.T. (2009) Co-expression of Argonaute2 enhances short hairpin RNAinduced RNA interference in Xenopus CNS neurons in vivo. Front. Neurosci., 3, 63.
    • (2009) Front. Neurosci. , vol.3 , pp. 63
    • Chen, C.M.1    Chiu, S.L.2    Shen, W.3    Cline, H.T.4
  • 61
    • 80052441245 scopus 로고    scopus 로고
    • Argonaute-2 enhances suppression of human cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122
    • Shao, P.L., Lu, M.Y., Liau, Y.J., Chao, M.F., Chang, L.Y., Lu, C.Y., Kao, C.L., Chang, S.Y., Chi, Y.H. and Huang, L.M. (2011) Argonaute-2 enhances suppression of human cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122. Antivir. Ther., 16, 741-749.
    • (2011) Antivir. Ther. , vol.16 , pp. 741-749
    • Shao, P.L.1    Lu, M.Y.2    Liau, Y.J.3    Chao, M.F.4    Chang, L.Y.5    Lu, C.Y.6    Kao, C.L.7    Chang, S.Y.8    Chi, Y.H.9    Huang, L.M.10
  • 62
    • 80051913931 scopus 로고    scopus 로고
    • When cellular networks run out of control: Global dysregulation of the RNAi machinery in human pathology and therapy
    • Mockenhaupt, S., Schurmann, N. and Grimm, D. (2011) When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy. Prog. Mol. Biol. Transl. Sci., 102, 165-242.
    • (2011) Prog. Mol. Biol. Transl. Sci. , vol.102 , pp. 165-242
    • Mockenhaupt, S.1    Schurmann, N.2    Grimm, D.3
  • 63
    • 33846702404 scopus 로고    scopus 로고
    • HIV-1 Tat interaction with Dicer: Requirement for RNA
    • Bennasser, Y. and Jeang, K.T. (2006) HIV-1 Tat interaction with Dicer: requirement for RNA. Retrovirology, 3, 95.
    • (2006) Retrovirology , vol.3 , pp. 95
    • Bennasser, Y.1    Jeang, K.T.2
  • 66
    • 84882814047 scopus 로고    scopus 로고
    • The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection
    • Casey Klockow, L., Sharifi, H.J., Wen, X., Flagg, M., Furuya, A.K., Nekorchuk, M. and de Noronha, C.M. (2013) The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. Virology, 444, 191-202.
    • (2013) Virology , vol.444 , pp. 191-202
    • Casey Klockow, L.1    Sharifi, H.J.2    Wen, X.3    Flagg, M.4    Furuya, A.K.5    Nekorchuk, M.6    De Noronha, C.M.7
  • 67
    • 58149457065 scopus 로고    scopus 로고
    • Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells
    • Adams, B.D., Claffey, K.P. and White, B.A. (2009) Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology, 150, 14-23.
    • (2009) Endocrinology , vol.150 , pp. 14-23
    • Adams, B.D.1    Claffey, K.P.2    White, B.A.3
  • 68
    • 84872794144 scopus 로고    scopus 로고
    • Overexpression of human Argonaute2 inhibits cell and tumor growth
    • Zhang, X., Graves, P. and Zeng, Y. (2012) Overexpression of human Argonaute2 inhibits cell and tumor growth. Biochim. Biophys. Acta, 1830, 2553-2561.
    • (2012) Biochim. Biophys. Acta , vol.1830 , pp. 2553-2561
    • Zhang, X.1    Graves, P.2    Zeng, Y.3
  • 69
    • 79952202489 scopus 로고    scopus 로고
    • MicroRNA Northern blotting, precursor cloning, and Ago2-improved RNA interference
    • Winter, J. and Diederichs, S. (2011) MicroRNA Northern blotting, precursor cloning, and Ago2-improved RNA interference. Methods Mol. Biol., 676, 85-100.
    • (2011) Methods Mol. Biol. , vol.676 , pp. 85-100
    • Winter, J.1    Diederichs, S.2
  • 70
    • 58149515780 scopus 로고    scopus 로고
    • Stable Argonaute2 overexpression differentially regulates microRNA production
    • Zhang, X., Graves, P.R. and Zeng, Y. (2009) Stable Argonaute2 overexpression differentially regulates microRNA production. Biochim. Biophys. Acta, 1789, 153-159.
    • (2009) Biochim. Biophys. Acta , vol.1789 , pp. 153-159
    • Zhang, X.1    Graves, P.R.2    Zeng, Y.3
  • 73
    • 79954580892 scopus 로고    scopus 로고
    • Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells
    • Detzer, A., Engel, C., Wunsche, W. and Sczakiel, G. (2011) Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells. Nucleic Acids Res., 39, 2727-2741.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 2727-2741
    • Detzer, A.1    Engel, C.2    Wunsche, W.3    Sczakiel, G.4
  • 74
    • 79958025810 scopus 로고    scopus 로고
    • Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis
    • Lund, E., Sheets, M.D., Imboden, S.B. and Dahlberg, J.E. (2011) Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis. Genes Dev., 25, 1121-1131.
    • (2011) Genes Dev. , vol.25 , pp. 1121-1131
    • Lund, E.1    Sheets, M.D.2    Imboden, S.B.3    Dahlberg, J.E.4
  • 76
    • 50549092566 scopus 로고    scopus 로고
    • Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic
    • Giering, J.C., Grimm, D., Storm, T.A. and Kay, M.A. (2008) Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Mol. Ther., 16, 1630-1636.
    • (2008) Mol. Ther. , vol.16 , pp. 1630-1636
    • Giering, J.C.1    Grimm, D.2    Storm, T.A.3    Kay, M.A.4
  • 78
    • 77957807722 scopus 로고    scopus 로고
    • Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors
    • Saayman, S., Arbuthnot, P. and Weinberg, M.S. (2010) Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors. Nucleic Acids Res., 38, 6652-6663.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 6652-6663
    • Saayman, S.1    Arbuthnot, P.2    Weinberg, M.S.3
  • 79
    • 84861662510 scopus 로고    scopus 로고
    • Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs
    • Scott, T., Paweska, J.T., Arbuthnot, P. and Weinberg, M.S. (2012) Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs. Antivir. Ther., 17, 643-656.
    • (2012) Antivir. Ther. , vol.17 , pp. 643-656
    • Scott, T.1    Paweska, J.T.2    Arbuthnot, P.3    Weinberg, M.S.4


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