The dose can make the poison: Lessons learned from adverse in vivo toxicities caused by RNAi overexpression

Silence

Volumn 2, Issue 1, 2011, Pages

  Grimm, Dirk ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

MiRNA; RNAi; Saturation; ShRNA; Toxicity; Viral vector

Indexed keywords

AMINOTRANSFERASE; ARGONAUTE PROTEIN; EXPORTIN 5; LENTIVIRUS VECTOR; MICRORNA; MICRORNA 122; RNA POLYMERASE II; SHORT HAIRPIN RNA; VIRUS RNA; VIRUS VECTOR;

AMINOTRANSFERASE BLOOD LEVEL; CARCINOGENESIS; CELL DEATH; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; IMMUNE RESPONSE; IN VIVO STUDY; LIVER TOXICITY; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; RNA TRANSLATION; SHORT SURVEY; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84862217953     PISSN: None     EISSN: 1758907X     Source Type: Journal    
DOI: 10.1186/1758-907X-2-8     Document Type: Short Survey

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