De novo-designed metallopeptides with type 2 copper centers: Modulation of reduction potentials and nitrite reductase activities

Journal of the American Chemical Society

Volumn 135, Issue 48, 2013, Pages 18096-18107

  Yu, Fangting ^a   Penner Hahn, James E ^a   Pecoraro, Vincent L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER NITRITE REDUCTASE; COPPER-PEPTIDE COMPLEXES; DE NOVO PROTEIN DESIGN; ELECTRON TRANSFER CENTERS; ELECTROSTATIC ENVIRONMENTS; INFLUENTIAL FACTORS; PROTONATION EQUILIBRIA; STRUCTURE-FUNCTION RELATIONSHIP;

AMINO ACIDS; BINDING ENERGY; CATALYST ACTIVITY; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; PEPTIDES; PH; REDOX REACTIONS;

COPPER COMPOUNDS;

ALPHA AMIDATING ENZYME; CUPRIC ION; GLUTAMIC ACID; LYSINE; METALLOPROTEIN; NITRITE REDUCTASE; PEPTIDYLGLYCINE ALPHA HYDROXYLATING MONOOXYGENASE; TRI EH METALLOPEPTIDE; TRI EHE27K METALLOPEPTIDE; TRI EHE27Q METALLOPEPTIDE; TRI EHK24E METALLOPEPTIDE; TRI EHK24Q METALLOPEPTIDE; TRI H METALLOPEPTIDE; TRI HK22Q METALLOPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ELECTRIC POTENTIAL; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME KINETICS; EQUILIBRIUM CONSTANT; FLUORESCENCE SPECTROSCOPY; METAL BINDING; MOLECULAR PROBE; OXIDATION REDUCTION REACTION; PH; PROTEIN ANALYSIS; PROTON TRANSPORT; REDUCTION KINETICS; ULTRAVIOLET SPECTROSCOPY; X RAY ABSORPTION SPECTROSCOPY;

AMINO ACID SEQUENCE; BINDING SITES; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITRITE REDUCTASES; OXIDATION-REDUCTION; PEPTIDES;

EID: 84889854266     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja406648n     Document Type: Article

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